Abstract:
:An amendment to this paper has been published and can be accessed via the original article.
journal_name
EJNMMI Resjournal_title
EJNMMI researchauthors
Ross MI,Bird N,Mendichovszky IA,Rimmer YLdoi
10.1186/s13550-020-00719-wsubject
Has Abstractpub_date
2020-10-27 00:00:00pages
129issue
1issn
2191-219Xpii
10.1186/s13550-020-00719-wjournal_volume
10pub_type
已发布勘误相关文献
EJNMMI Research文献大全abstract:BACKGROUND:Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor. Currently, 18F-fluoro-deoxy-glucose (18F-FDG) PET/CT is the functional imaging modality of choice. Few data are available on the use of 68Ga-somatostatin analogs. The aim of our study was to evaluate and compare the diagnostic performanc...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0423-3
更新日期:2018-07-21 00:00:00
abstract:BACKGROUND:In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [18F]flortanidazole ([18F]HX4) small-animal positron emission tomography (μPET). We also assessed the additive effect of metformin on long-term radiotherapy outcome and we studied the potential o...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0543-4
更新日期:2019-08-02 00:00:00
abstract:BACKGROUND:The molecular features of isocitrate dehydrogenase (IDH) mutation and chromosome 1p and 19q (1p/19q) codeletion status have pivotal role for differentiating gliomas and have been integrated in the World Health Organization (WHO) classification in 2016. Positron emission tomography (PET) with 3'-deoxy-3'-[18F...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00633-1
更新日期:2020-05-07 00:00:00
abstract:BACKGROUND:[18 F]fluorodopa (FDOPA) positron emission tomography (PET) allows assessment of levodopa (LDOPA) metabolism and is widely used to study Parkinson's disease. We examined how [18 F]FDOPA PET-derived kinetic parameters relate the dopamine (DA) and DA metabolite content of extracellular fluid measured by microd...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-3-69
更新日期:2013-10-02 00:00:00
abstract:BACKGROUND:We aimed to determine the accuracy of laser Doppler perfusion imaging (LDPI) in an animal model for hind limb ischemia. METHODS:We used a murine (C57Bl/6 mice) ischemic hind limb model in which we compared LDPI with the clinically used (99m)Tc-sestamibi SPECT perfusion imaging (n = 7). In addition, we used ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0199-2
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the prognostic value of positron emission tomography (PET) parameters and the PET texture features of fluorine 18-fluorodeoxyglucose ([18F]FDG) uptake on pretreatment PET/computed tomography (CT) in patients with locally advanced salivary gland carcinoma treated with int...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0555-0
更新日期:2019-09-11 00:00:00
abstract:BACKGROUND:Noninvasive preclinical imaging methodologies such as small animal positron emission tomography (PET) allow the repeated measurement of the same subject which is generally assumed to reduce the variability of the experimental outcome parameter and to produce more robust results. In this study, the variabilit...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-26
更新日期:2012-06-09 00:00:00
abstract:: The classical attitude of Nuclear Medicine practitioners on matters of peptide-receptor interactions has maintained an intrinsic monogamic character since many years. New advances in the field of biochemistry and even in clinical Nuclear Medicine have challenged this type of thinking, which prompted me to work on thi...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-1-9
更新日期:2011-07-26 00:00:00
abstract:BACKGROUND:Targeted alpha therapy (TAT) offers advantages over current β-emitting conjugates for peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. PRRT with 177Lu-DOTATATE or 90Y-DOTATOC has shown dose-limiting nephrotoxicity due to radiopeptide retention in the proximal tubules. Pharmacological pr...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0240-5
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Macrophages represent a critical cell type in host defense, development and homeostasis. The ability to image non-invasively pro-inflammatory macrophage infiltrate into a transplanted organ may provide an additional tool for the monitoring of the immune response of the recipient against the donor graft. We t...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-015-0146-7
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:In order to better understand the concept of mechanical dyssynchrony, a promising hallmark of cardiac resynchronization therapy (CRT) response, we investigated its effect on regional myocardial metabolism and myocardial blood flow (MBF) in non-ischemic CRT candidates. RESULTS:Thirty consecutive non-ischemic...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0575-9
更新日期:2019-12-09 00:00:00
abstract:BACKGROUND:Given the increasing clinical use of PET/MRI, potential risks to patients from simultaneous exposure to ionising radiation and (electro)magnetic fields should be thoroughly investigated as a precaution. With this aim, the genotoxic potential of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and a strong static m...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00625-1
更新日期:2020-04-28 00:00:00
abstract:BACKGROUND:In the present study, we used multimodal imaging to investigate biodistribution in rats after intravenous administration of a new 99mTc-labeled delivery system consisting of polymer-shelled microbubbles (MBs) functionalized with diethylenetriaminepentaacetic acid (DTPA), thiolated poly(methacrylic acid) (PMA...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-3-12
更新日期:2013-02-25 00:00:00
abstract:PURPOSE:To investigate the added value and diagnostic accuracy of 68Ga-PSMA PET/CT versus bone scintigraphy (BS) for bone metastasis detection at the primary staging of prostate cancer (PCa). METHODS:Inclusion criteria involved consecutive patients with newly diagnosed intermediate- to high-risk PCa, who had undergone...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00618-0
更新日期:2020-04-08 00:00:00
abstract:BACKGROUND:F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising modality for detecting active lesions of cardiac sarcoidosis (CS). However, determining whether 18F-FDG uptake in the myocardium is physiological is challenging due to metabolic shift in myocardial cells. Although methods for inhibi...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-4-1
更新日期:2014-01-02 00:00:00
abstract:BACKGROUND:Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial preclinical evaluation of PET tracers is often conducted in rodents due to the accessibility of disease models as well as economic considerations. Compared to larger ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00718-x
更新日期:2020-10-19 00:00:00
abstract:BACKGROUND:Glioblastoma, the most frequent and aggressive of all astrocytomas, presents a clear predominance in male humans, but the assessment of sexual differences in its tumourigenesis and growth has received little attention so far. In this study, we aim to identify gender-dependent surrogate markers in an animal m...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0044-4
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Amino acid co-infusion for renal protection in endoradiotherapy (ERT) applied as prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) or peptide receptor radionuclide therapy (PRRT) has been shown to cause severe hyperkalemia. The pathophysiology behind the rapid development of hyperk...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0370-z
更新日期:2018-02-27 00:00:00
abstract:UNLABELLED: BACKGROUND:Iodine-123-β-CIT, a single-photon emission computed tomography (SPECT) ligand for dopamine transporters (DATs), has been used for in vivo studies in humans, monkeys, and rats but has not yet been used extensively in mice. To validate the imaging and analysis methods for preclinical DAT imaging, ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-55
更新日期:2012-09-29 00:00:00
abstract:BACKGROUND:High expression of human epidermal growth factor receptor type 2 (HER2) represents an aggressive subtype of breast cancer. Anti-HER2 treatment requires a theragnostic approach wherein sufficiently high receptor expression in biopsy material is mandatory. Heterogeneity and discordance of HER2 expression betwe...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-0603-9
更新日期:2020-03-23 00:00:00
abstract:BACKGROUND:To assess 18-fluorodeoxyglucose (FDG) bowel uptake in patients with differentiated thyroid cancer (DTC) treated with sorafenib. FINDINGS:Visual (5-point scale) and high maximum standard uptake value (SUVmax) semi-quantitative analyses were conducted in 63 positron emission tomography (PET) studies performed...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-18
更新日期:2012-05-07 00:00:00
abstract:BACKGROUND:Cerebral blood flow (CBF) quantitation using technetium-99m hexamethylpropyleneamine oxime (99mTc-HMPAO) generally requires assessment of input function by arterial blood sampling, which would be invasive for small animals. We therefore performed chest dynamic planar imaging, instead of arterial blood sampli...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0375-7
更新日期:2018-03-09 00:00:00
abstract:BACKGROUND:Diacetyl-bis(N4-methylthiosemicarbazone), labeled with 64Cu (64Cu-ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various controversial studies highlighted potential pitfalls that may disable its use as a selective hypoxic marker. They also highlighted that the results may be tum...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0586-6
更新日期:2019-12-19 00:00:00
abstract:PURPOSE:We have developed a multi-modal imaging approach for SIRT, combining 99mTc-MAA SPECT/CT and/or 90Y PET, 18F-FDG PET/CT, and contrast-enhanced CBCT for voxel-based dosimetry, as a tool for treatment planning and verification. For radiation dose prediction calculations, a segmentation of the total liver volume an...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0485-x
更新日期:2019-02-20 00:00:00
abstract:BACKGROUND:New therapies to treat diabetic peripheral artery disease (PAD) require target-specific non-invasive imaging modalities to follow efficacy. As a translational study, we performed targeted imaging of receptors for vascular endothelial growth factor (VEGF) in response to anterior femoral artery occlusion (FAO)...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00626-0
更新日期:2020-05-12 00:00:00
abstract:BACKGROUND:177Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remission is rarely seen, and optimization of treatment protocols is needed. In vitro studies have shown that irradiation can up-regu...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0247-y
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Somatostatin receptor (SST) targeting, specifically of the subtype 2 (SST2), with radiolabeled somatostatin analogs, is established for imaging and treatment of neuroendocrine tumors. Owing to the concomitant and heterogeneous expression of several subtypes on the same tumor, analogs targeting more subtypes ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00677-3
更新日期:2020-08-05 00:00:00
abstract:BACKGROUND:In contrast to ordered subset expectation maximization (OSEM), block sequential regularized expectation maximization (BSREM) positron emission tomography (PET) reconstruction algorithms can run until full convergence while controlling image quality and noise. Recent studies with BSREM and 18F-FDG PET reporte...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0414-4
更新日期:2018-07-27 00:00:00
abstract:BACKGROUND:Differentiated thyroid carcinoma (DTC) is the most common type of thyroid cancer. Treatment with surgery, radioactive iodine (RAI), and TSH suppression is effective in most patients. Five to 15% of patients become RAI refractory and need alternative therapy; however, treatment options are limited. 68Ga-PSMA ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-0610-x
更新日期:2020-03-06 00:00:00
abstract:BACKGROUND:In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of 68Ga-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated u...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0259-2
更新日期:2017-12-01 00:00:00