Multiparametric magnetic resonance in the assessment of the gender differences in a high-grade glioma rat model.

abstract：PURPOSE:Chimeric antibody Miltuximab®, a human IgG1 engineered from the parent antibody MIL-38, is in clinical development for solid tumour therapy. Miltuximab® targets glypican-1 (GPC-1), a cell surface protein involved in tumour growth, which is overexpressed in solid tumours, including prostate cancer (PCa). This st...

journal_title：EJNMMI research

authors： Yeh MC,Tse BWC,Fletcher NL,Houston ZH,Lund M,Volpert M,Stewart C,Sokolowski KA,Jeet V,Thurecht KJ,Campbell DH,Walsh BJ,Nelson CC,Russell PJ

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:We aimed to determine the accuracy of laser Doppler perfusion imaging (LDPI) in an animal model for hind limb ischemia. METHODS:We used a murine (C57Bl/6 mice) ischemic hind limb model in which we compared LDPI with the clinically used (99m)Tc-sestamibi SPECT perfusion imaging (n = 7). In addition, we used ...

journal_title：EJNMMI research

authors： Hendrikx G,Vries MH,Bauwens M,De Saint-Hubert M,Wagenaar A,Guillaume J,Boonen L,Post MJ,Mottaghy FM

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising modality for detecting active lesions of cardiac sarcoidosis (CS). However, determining whether 18F-FDG uptake in the myocardium is physiological is challenging due to metabolic shift in myocardial cells. Although methods for inhibi...

journal_title：EJNMMI research

authors： Morooka M,Moroi M,Uno K,Ito K,Wu J,Nakagawa T,Kubota K,Minamimoto R,Miyata Y,Okasaki M,Okazaki O,Yamada Y,Yamaguchi T,Hiroe M

更新日期：2014-01-02 00:00:00

abstract：BACKGROUND:In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of 68Ga-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated u...

journal_title：EJNMMI research

authors： Velasco C,Mateo J,Santos A,Mota-Cobian A,Herranz F,Pellico J,Mota RA,España S,Ruiz-Cabello J

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Radioembolization is an established treatment modality in colorectal cancer patients with liver-dominant disease in a salvage setting. Selection of patients who will benefit most is of vital importance. The aim of this study was to assess response (and mode of progression) at 3 months after radioembolization...

journal_title：EJNMMI research

authors： van Roekel C,Jongen JMJ,Smits MLJ,Elias SG,Koopman M,Kranenburg O,Borel Rinkes IHM,Lam MGEH

更新日期：2020-09-22 00:00:00

abstract：BACKGROUND:Cerebral blood flow (CBF) quantitation using technetium-99m hexamethylpropyleneamine oxime (99mTc-HMPAO) generally requires assessment of input function by arterial blood sampling, which would be invasive for small animals. We therefore performed chest dynamic planar imaging, instead of arterial blood sampli...

journal_title：EJNMMI research

authors： Suzuki C,Kosugi M,Magata Y

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:We investigated the association between physiologic bowel FDG uptake and gut microbiota. FDG uptake in the normal large and small intestine is widely variable both in distribution and intensity. The etiology of physiologic bowel 18F-FDG activity remains unknown. RESULTS:We included 63 healthy male subjects....

journal_title：EJNMMI research

authors： Kang JY,Kim HN,Chang Y,Yun Y,Ryu S,Shin H,Kim HL

更新日期：2017-08-31 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess the relationship of CT-perfusion (CTP), 18F-FDG-PET/CT and histological parameters, and the possible added value of CTP to FDG-PET/CT in the initial staging of lung cancer. METHODS:Fifty-four consecutive patients (median age 65 years, 15 females, 39 males) with suspec...

journal_title：EJNMMI research

authors： Huellner MW,Collen TD,Gut P,Winterhalder R,Pauli C,Diebold J,Seifert B,Strobel K,Veit-Haibach P

更新日期：2014-01-22 00:00:00

abstract：INTRODUCTION:The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible. METHODS:For 20 existing [18F]GE-179 datasets, we generated (1) standardised uptake values (SUVs) o...

journal_title：EJNMMI research

authors： McGinnity CJ,Riaño Barros DA,Trigg W,Brooks DJ,Hinz R,Duncan JS,Koepp MJ,Hammers A

更新日期：2018-06-11 00:00:00

abstract：:Targeted agents are increasingly used for treating cancer and other diseases, but patients may need to be carefully selected to maximize the potential for therapeutic benefit. One way to select patients is to bind an imaging radionuclide to a targeting agent of interest, so that its uptake in specific sites of disease...

journal_title：EJNMMI research

authors： McBride WJ,Sharkey RM,Goldenberg DM

更新日期：2013-05-08 00:00:00

abstract：BACKGROUND:The biology of the vulnerable plaque includes increased inflammation and rapid growth of vasa vasorum, processes that are associated with enhanced vascular endothelial growth factor (VEGF)/ imaging receptors for VEGF (VEGFR) signaling and are accelerated in diabetes. This study was designed to test the hypot...

journal_title：EJNMMI research

authors： Tekabe Y,Kollaros M,Zerihoun A,Zhang G,Backer MV,Backer JM,Johnson LL

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Routine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pretreatment liver function and its segmental distribution, using hepatobiliary scintigraphy may improv...

journal_title：EJNMMI research

authors： Braat MNGJA,de Jong HW,Seinstra BA,Scholten MV,van den Bosch MAAJ,Lam MGEH

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Assessing the extent of disease in newly diagnosed prostate cancer (PC) patients is crucial for tailoring an appropriate treatment approach. Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography/computed tomography (PET/CT) reportedly has greater accuracy than conventional imaging f...

journal_title：EJNMMI research

authors： Kuten J,Dekalo S,Mintz I,Yossepowitch O,Mano R,Even-Sapir E

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Molecular breast imaging (MBI) performed with 99mTc sestamibi has been shown to be a valuable technique for the detection of breast cancer. Alternative radiotracers such as 99mTc maraciclatide may offer improved uptake in breast lesions. The purpose of this study was to compare relative performance of 99mTc ...

journal_title：EJNMMI research

authors： O'Connor MK,Morrow MMB,Hunt KN,Boughey JC,Wahner-Roedler DL,Conners AL,Rhodes DJ,Hruska CB

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Vagus nerve activation impacts inflammation. Therefore, we hypothesized that vagal nerve stimulation (VNS) influenced arterial wall inflammation as measured by 18F-FDG uptake. RESULTS:Ten patients with left-sided VNS for refractory epilepsy were studied during stimulation (VNS-on) and in the hours after sti...

journal_title：EJNMMI research

authors： Boswijk E,Franssen R,Vijgen GHEJ,Wierts R,van der Pol JAJ,Mingels AMA,Cornips EMJ,Majoie MHJM,van Marken Lichtenbelt WD,Mottaghy FM,Wildberger JE,Bucerius J

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the prognostic value of positron emission tomography (PET) parameters and the PET texture features of fluorine 18-fluorodeoxyglucose ([18F]FDG) uptake on pretreatment PET/computed tomography (CT) in patients with locally advanced salivary gland carcinoma treated with int...

journal_title：EJNMMI research

authors： Wu WJ,Li ZY,Dong S,Liu SM,Zheng L,Huang MW,Zhang JG

更新日期：2019-09-11 00:00:00

abstract：BACKGROUND:Biologicals directed against tumour necrosis factor (TNF) have proven their efficacy in the treatment of spondyloarthritis and rheumatoid arthritis. We present a radiolabelling method for certolizumab pegol (CZP), a commercially available humanized Fab'-fragment directed against TNF. A biodistribution and do...

journal_title：EJNMMI research

authors： Lambert B,Carron P,D'Asseler Y,Bacher K,Van den Bosch F,Elewaut D,Verbruggen G,Beyaert R,Dumolyn C,De Vos F

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Targeted alpha therapy (TAT) offers advantages over current β-emitting conjugates for peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. PRRT with 177Lu-DOTATATE or 90Y-DOTATOC has shown dose-limiting nephrotoxicity due to radiopeptide retention in the proximal tubules. Pharmacological pr...

journal_title：EJNMMI research

authors： Chan HS,Konijnenberg MW,Daniels T,Nysus M,Makvandi M,de Blois E,Breeman WA,Atcher RW,de Jong M,Norenberg JP

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Diacetyl-bis(N4-methylthiosemicarbazone), labeled with 64Cu (64Cu-ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various controversial studies highlighted potential pitfalls that may disable its use as a selective hypoxic marker. They also highlighted that the results may be tum...

journal_title：EJNMMI research

authors： Pérès EA,Toutain J,Paty LP,Divoux D,Ibazizène M,Guillouet S,Barré L,Vidal A,Cherel M,Bourgeois M,Bernaudin M,Valable S

更新日期：2019-12-19 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors (TKIs) have experienced a tremendous boost in the last decade, where more than 15 small molecule TKIs have been approved by the FDA. Unfortunately, despite their promising clinical successes, a large portion of patients remain unresponsive to these targeted drugs. For non-small cel...

journal_title：EJNMMI research

authors： Slobbe P,Windhorst AD,Stigter-van Walsum M,Smit EF,Niessen HG,Solca F,Stehle G,van Dongen GA,Poot AJ

更新日期：2015-03-20 00:00:00

abstract：BACKGROUND:[18 F]fluorodopa (FDOPA) positron emission tomography (PET) allows assessment of levodopa (LDOPA) metabolism and is widely used to study Parkinson's disease. We examined how [18 F]FDOPA PET-derived kinetic parameters relate the dopamine (DA) and DA metabolite content of extracellular fluid measured by microd...

journal_title：EJNMMI research

authors： Walker MD,Dinelle K,Kornelsen R,Lee A,Farrer MJ,Stoessl AJ,Sossi V

更新日期：2013-10-02 00:00:00

abstract：BACKGROUND:In molecular imaging and nuclear medicine, theranostic agents that integrate radionuclide pairs are successfully being used for individualized care, which has led to rapidly growing interest in their continued development. These compounds, which are radiolabeled with one radionuclide for imaging and a chemic...

journal_title：EJNMMI research

authors： Loveless CS,Radford LL,Ferran SJ,Queern SL,Shepherd MR,Lapi SE

更新日期：2019-05-16 00:00:00

abstract：BACKGROUND:18F-FDG-PET imaging has emerged as a promising method in the diagnosis of chronic osteomyelitis commonly due to Staphylococcus aureus. The inaccuracy of 18 F-FDG-PET in the detection of periprosthetic joint infections may be related to the predominance of low-virulent S. epidermidis strains as the causative ...

journal_title：EJNMMI research

authors： Lankinen P,Lehtimäki K,Hakanen AJ,Roivainen A,Aro HT

更新日期：2012-07-23 00:00:00

abstract：BACKGROUND:Peptide receptor radionuclide therapy (PRRT) is applied in patients with advanced neuroendocrine tumors. Co-infused amino acids (AA) should prevent nephrotoxicity. The aims of this study were to correlate the incidence of AA-induced hyperkalemia (HK) (≥5.0 mmol/l) and to identify predictors of AA-induced sev...

journal_title：EJNMMI research

authors： Lapa C,Werner RA,Bluemel C,Lueckerath K,Muegge DO,Strate A,Haenscheid H,Schirbel A,Allen-Auerbach MS,Bundschuh RA,Buck AK,Herrmann K

更新日期：2014-12-24 00:00:00

abstract：BACKGROUND:In contrast to ordered subset expectation maximization (OSEM), block sequential regularized expectation maximization (BSREM) positron emission tomography (PET) reconstruction algorithms can run until full convergence while controlling image quality and noise. Recent studies with BSREM and 18F-FDG PET reporte...

journal_title：EJNMMI research

authors： Ter Voert EEGW,Muehlematter UJ,Delso G,Pizzuto DA,Müller J,Nagel HW,Burger IA

更新日期：2018-07-27 00:00:00

abstract：BACKGROUND:The availability of GABAA receptor binding sites in the brain can be assessed by positron emission tomography (PET) using the radioligand, [18F]flumazenil. However, the brain uptake and binding of this PET radioligand are influenced by anesthetic drugs, which are typically needed in preclinical imaging studi...

journal_title：EJNMMI research

authors： Palner M,Beinat C,Banister S,Zanderigo F,Park JH,Shen B,Hjoernevik T,Jung JH,Lee BC,Kim SE,Fung L,Chin FT

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:We recently showed improved between-subject variability in our [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) experiments using a Michaelis-Menten transport model to calculate the metabolic tumor glucose uptake rate extrapolated to the hypothetical condition of glucose saturation: MRgl...

journal_title：EJNMMI research

authors： Williams SP,Flores-Mercado JE,Baudy AR,Port RE,Bengtsson T

更新日期：2012-06-27 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：EJNMMI research

authors： Ross MI,Bird N,Mendichovszky IA,Rimmer YL

更新日期：2020-10-27 00:00:00

abstract：BACKGROUND:Macrophages represent a critical cell type in host defense, development and homeostasis. The ability to image non-invasively pro-inflammatory macrophage infiltrate into a transplanted organ may provide an additional tool for the monitoring of the immune response of the recipient against the donor graft. We t...

journal_title：EJNMMI research

authors： O'Neill AS,Terry SY,Brown K,Meader L,Wong AM,Cooper JD,Crocker PR,Wong W,Mullen GE

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand. METHODS:The binding characteristics of the selected candidate, AZ12204657, at human GPR44 were determined using in vitro ligand bindi...

journal_title：EJNMMI research

authors： Jahan M,Johnström P,Selvaraju RK,Svedberg M,Winzell MS,Bernström J,Kingston L,Schou M,Jia Z,Skrtic S,Johansson L,Korsgren O,Farde L,Halldin C,Eriksson O

更新日期：2018-12-27 00:00:00