Abstract:
BACKGROUND:PET/MRI can be used for the detection of disease in biochemical recurrence (BCR) patients imaged with 68Ga-PSMA-11 PET. This study was designed to determine the optimal MRI sequences to localize positive findings on 68Ga-PSMA-11 PET of patients with BCR after definitive therapy. Fifty-five consecutive prostate cancer patients with BCR imaged with 68Ga-PSMA-11 3.0T PET/MRI were retrospectively analyzed. Mean PSA was 7.9 ± 12.9 ng/ml, and mean PSA doubling time was 7.1 ± 6.6 months. Detection rates of anatomic correlates for prostate-specific membrane antigen (PSMA)-positive foci were evaluated on small field of view (FOV) T2, T1 post-contrast, and diffusion-weighted images. For prostate bed recurrences, the detection rate of dynamic contrast-enhanced (DCE) imaging for PSMA-positive foci was evaluated. Finally, the detection sensitivity for PSMA-avid foci on 3- and 8-min PET acquisitions was compared. RESULTS:PSMA-positive foci were detected in 89.1% (49/55) of patients evaluated. Small FOV T2 performed best for lymph nodes and detected correlates for all PSMA-avid lymph nodes. DCE imaging performed the best for suspected prostate bed recurrence, detecting correlates for 87.5% (14/16) of PSMA-positive prostate bed foci. The 8-min PET acquisition performed better than the 3-min acquisition for lymph nodes smaller than 1 cm, detecting 100% (57/57) of lymph nodes less than 1 cm, compared to 78.9% (45/57) for the 3-min acquisition. CONCLUSION:PSMA PET/MRI performed well for the detection of sites of suspected recurrent disease in patients with BCR. Of the MRI sequences obtained for localization, small FOV T2 images detected the greatest proportion of PSMA-positive abdominopelvic lymph nodes and DCE imaging detected the greatest proportion of PSMA-positive prostate bed foci. The 8-min PET acquisition was superior to the 3 min acquisition for detection of small lymph nodes.
journal_name
EJNMMI Resjournal_title
EJNMMI researchauthors
Lake ST,Greene KL,Westphalen AC,Behr SC,Zagoria R,Small EJ,Carroll PR,Hope TAdoi
10.1186/s13550-017-0327-7subject
Has Abstractpub_date
2017-09-19 00:00:00pages
77issue
1issn
2191-219Xpii
10.1186/s13550-017-0327-7journal_volume
7pub_type
杂志文章相关文献
EJNMMI Research文献大全abstract:BACKGROUND:[11C]methionine (MET) has been used to monitor amino acid metabolism in tumors, the pancreas, liver, and myocardium. The aim of the present study was to standardize [11C]MET positron emission tomography (PET) by optimizing the timing of initiation of the scan and applying correction to the plasma concentrati...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-3-27
更新日期:2013-04-15 00:00:00
abstract:BACKGROUND:Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor. Currently, 18F-fluoro-deoxy-glucose (18F-FDG) PET/CT is the functional imaging modality of choice. Few data are available on the use of 68Ga-somatostatin analogs. The aim of our study was to evaluate and compare the diagnostic performanc...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0423-3
更新日期:2018-07-21 00:00:00
abstract:BACKGROUND:Peptide receptor radionuclide therapy (PRRT) is applied in patients with advanced neuroendocrine tumors. Co-infused amino acids (AA) should prevent nephrotoxicity. The aims of this study were to correlate the incidence of AA-induced hyperkalemia (HK) (≥5.0 mmol/l) and to identify predictors of AA-induced sev...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0074-y
更新日期:2014-12-24 00:00:00
abstract:UNLABELLED: BACKGROUND:In single-photon emission computed tomography (SPECT), attenuation of photon flux in tissue affects quantitative accuracy of reconstructed images. Attenuation maps derived from X-ray computed tomography (CT) can be employed for attenuation correction. The attenuation coefficients as well as regi...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-3-7
更新日期:2013-01-31 00:00:00
abstract:BACKGROUND:Assessment of liver function is critical in hepatocellular carcinoma (HCC) patient management. We evaluated parameters of [(99m)Tc] sulfur colloid (SC) SPECT/CT liver uptake for association with clinical measures of liver function and outcome in HCC patients. METHODS:Thirty patients with HCC and variable Ch...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0212-9
更新日期:2016-12-01 00:00:00
abstract::Nanobodies are the recombinant variable domains of heavy-chain-only antibodies, with many unique properties such as small size, excellent solubility, superior stability, quick clearance from blood, and deep tissue penetration. As a result, nanobodies have become a promising tool for the diagnosis and therapy of diseas...
journal_title:EJNMMI research
pub_type: 杂志文章,评审
doi:10.1186/s13550-021-00750-5
更新日期:2021-01-19 00:00:00
abstract:BACKGROUND:Noninvasive preclinical imaging methodologies such as small animal positron emission tomography (PET) allow the repeated measurement of the same subject which is generally assumed to reduce the variability of the experimental outcome parameter and to produce more robust results. In this study, the variabilit...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-26
更新日期:2012-06-09 00:00:00
abstract:BACKGROUND:We quantified myocardial blood flow with (82)Rb PET using parameters of the generalized Renkin-Crone model estimated from (82)Rb and (15)O-water images reconstructed with time-of-flight and point spread function modeling. Previous estimates of rubidium extraction have used older-generation scanners without t...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0215-6
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess the relationship of CT-perfusion (CTP), 18F-FDG-PET/CT and histological parameters, and the possible added value of CTP to FDG-PET/CT in the initial staging of lung cancer. METHODS:Fifty-four consecutive patients (median age 65 years, 15 females, 39 males) with suspec...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-4-6
更新日期:2014-01-22 00:00:00
abstract:BACKGROUND:Hepatobiliary scintigraphy using (99m)Tc-mebrofenin has been used as an investigation to study liver function after liver transplantation (LTx). Hepatic extraction fraction (HEF) is a measurement of the hepatic extraction efficiency and hepatic extraction rate. With the purpose of evaluating a possible diver...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0073-z
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the prognostic value of positron emission tomography (PET) parameters and the PET texture features of fluorine 18-fluorodeoxyglucose ([18F]FDG) uptake on pretreatment PET/computed tomography (CT) in patients with locally advanced salivary gland carcinoma treated with int...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0555-0
更新日期:2019-09-11 00:00:00
abstract:BACKGROUND:Prostate cancer is highly prevalent worldwide. Androgen deprivation therapy (ADT) remains the treatment of choice for incurable prostate cancer, but majority of patients develop disease recurrence following ADT. There is therefore an urgent need for early detection of treatment resistance. METHODS:Isogenic ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00728-9
更新日期:2020-11-25 00:00:00
abstract:BACKGROUND:We aimed to determine the accuracy of laser Doppler perfusion imaging (LDPI) in an animal model for hind limb ischemia. METHODS:We used a murine (C57Bl/6 mice) ischemic hind limb model in which we compared LDPI with the clinically used (99m)Tc-sestamibi SPECT perfusion imaging (n = 7). In addition, we used ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0199-2
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Fluorine-18 fluoroethoxybenzovesamicol ([18F]FEOBV) is a radioligand for the selective imaging of the vesicular acetylcholine transporter with positron emission tomography (PET). The current study demonstrates that pathological cortical cholinergic deafferentation can be quantified in vivo with [18F]FEOBV PE...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-3-70
更新日期:2013-10-09 00:00:00
abstract:BACKGROUND:We recently showed improved between-subject variability in our [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) experiments using a Michaelis-Menten transport model to calculate the metabolic tumor glucose uptake rate extrapolated to the hypothetical condition of glucose saturation: MRgl...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-35
更新日期:2012-06-27 00:00:00
abstract:UNLABELLED: BACKGROUND:Iodine-123-β-CIT, a single-photon emission computed tomography (SPECT) ligand for dopamine transporters (DATs), has been used for in vivo studies in humans, monkeys, and rats but has not yet been used extensively in mice. To validate the imaging and analysis methods for preclinical DAT imaging, ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-55
更新日期:2012-09-29 00:00:00
abstract::Targeted agents are increasingly used for treating cancer and other diseases, but patients may need to be carefully selected to maximize the potential for therapeutic benefit. One way to select patients is to bind an imaging radionuclide to a targeting agent of interest, so that its uptake in specific sites of disease...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-3-36
更新日期:2013-05-08 00:00:00
abstract:BACKGROUND:Radioembolization is an established treatment modality in colorectal cancer patients with liver-dominant disease in a salvage setting. Selection of patients who will benefit most is of vital importance. The aim of this study was to assess response (and mode of progression) at 3 months after radioembolization...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00697-z
更新日期:2020-09-22 00:00:00
abstract:BACKGROUND:Tenascin-C (TNC), an extracellular matrix glycoprotein, is expressed transiently in distinct areas in association with active tissue remodeling. This study aimed to explore how ischemic postconditioning (PC) affects myocardial expression of TNC and ventricular remodeling using (125)I-labeled anti-TNC antibod...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-015-0100-8
更新日期:2015-04-02 00:00:00
abstract:BACKGROUND:Hypoxic tumours exhibit increased resistance to radiation, chemical, and immune therapies. 18F-fluoromisonidazole (FMISO) positron emission tomography (PET) is a non-invasive, quantitative imaging technique used to evaluate the presence and spatial distribution of tumour hypoxia. To facilitate the use of FMI...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0210-y
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:High expression of human epidermal growth factor receptor type 2 (HER2) represents an aggressive subtype of breast cancer. Anti-HER2 treatment requires a theragnostic approach wherein sufficiently high receptor expression in biopsy material is mandatory. Heterogeneity and discordance of HER2 expression betwe...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-0603-9
更新日期:2020-03-23 00:00:00
abstract:BACKGROUND:Image-guided surgery may improve surgical outcome for colorectal cancer patients. Here, we evaluated the feasibility of a pretargeting strategy for multimodal imaging in colorectal cancer using an anti-carcinoembryonic antigen (CEA) x anti-histamine-succinyl-glycine (HSG) bispecific antibody (TF2) in conjunc...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0551-4
更新日期:2019-09-04 00:00:00
abstract:BACKGROUND:Dosimetry in radionuclide therapy has the potential to allow for a treatment tailored to the individual patient. One therapeutic radiopharmaceutical where patient-specific dosimetry is feasible is 177Lu-DOTATATE, used for the treatment of neuroendocrine tumours. The emission of gamma photons by 177Lu allows ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0262-7
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Cerebral blood flow (CBF) quantitation using technetium-99m hexamethylpropyleneamine oxime (99mTc-HMPAO) generally requires assessment of input function by arterial blood sampling, which would be invasive for small animals. We therefore performed chest dynamic planar imaging, instead of arterial blood sampli...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0375-7
更新日期:2018-03-09 00:00:00
abstract:BACKGROUND:Vagus nerve activation impacts inflammation. Therefore, we hypothesized that vagal nerve stimulation (VNS) influenced arterial wall inflammation as measured by 18F-FDG uptake. RESULTS:Ten patients with left-sided VNS for refractory epilepsy were studied during stimulation (VNS-on) and in the hours after sti...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0567-9
更新日期:2019-11-27 00:00:00
abstract:BACKGROUND:In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of 68Ga-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated u...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0259-2
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during treatment and persisting metabolic activity after apparent clinical cure. This poses a challenge in quantifying scan-...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-0591-9
更新日期:2020-02-10 00:00:00
abstract:BACKGROUND:In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [18F]flortanidazole ([18F]HX4) small-animal positron emission tomography (μPET). We also assessed the additive effect of metformin on long-term radiotherapy outcome and we studied the potential o...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0543-4
更新日期:2019-08-02 00:00:00
abstract:BACKGROUND:The use of radiolabeled choline as a positron emission tomography (PET) agent for imaging primary tumors in the prostate has been evaluated extensively over the past two decades. There are, however, conflicting reports of its sensitivity and the relationship between choline PET imaging and disease staging is...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0269-0
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Targeted alpha therapy (TAT) offers advantages over current β-emitting conjugates for peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. PRRT with 177Lu-DOTATATE or 90Y-DOTATOC has shown dose-limiting nephrotoxicity due to radiopeptide retention in the proximal tubules. Pharmacological pr...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0240-5
更新日期:2016-12-01 00:00:00