Abstract:
:Nanobodies are the recombinant variable domains of heavy-chain-only antibodies, with many unique properties such as small size, excellent solubility, superior stability, quick clearance from blood, and deep tissue penetration. As a result, nanobodies have become a promising tool for the diagnosis and therapy of diseases. As imaging tracers, nanobodies allow an early acquisition of high-quality images, provide a comprehensive evaluation of the disease, and subsequently enable a personalized precision therapy. As therapeutic agents, nanobodies enable a targeted therapy by lesion-specific delivery of drugs and effector domains, thereby improving the specificity and efficacy of the therapy. Up to date, a wide variety of nanobodies have been developed for a broad range of molecular targets and have played a significant role in patients with a broad spectrum of diseases. In this review, we aim to outline the current state-of-the-art research on the nanobodies for medical applications and then discuss the challenges and strategies for their further clinical translation.
journal_name
EJNMMI Resjournal_title
EJNMMI researchauthors
Bao G,Tang M,Zhao J,Zhu Xdoi
10.1186/s13550-021-00750-5subject
Has Abstractpub_date
2021-01-19 00:00:00pages
6issue
1issn
2191-219Xpii
10.1186/s13550-021-00750-5journal_volume
11pub_type
杂志文章,评审相关文献
EJNMMI Research文献大全abstract:BACKGROUND:In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of 68Ga-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated u...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0259-2
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Dosimetry in radionuclide therapy has the potential to allow for a treatment tailored to the individual patient. One therapeutic radiopharmaceutical where patient-specific dosimetry is feasible is 177Lu-DOTATATE, used for the treatment of neuroendocrine tumours. The emission of gamma photons by 177Lu allows ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0262-7
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Prostate-specific membrane antigen (PSMA) ligand PET/CT has already provided promising results in prostate cancer (PC) imaging, yet simple and reproductible reporting criteria are still lacking. This study aimed at retrospectively evaluating interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpret...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-0596-4
更新日期:2020-02-28 00:00:00
abstract:BACKGROUND:Tenascin-C (TNC), an extracellular matrix glycoprotein, is expressed transiently in distinct areas in association with active tissue remodeling. This study aimed to explore how ischemic postconditioning (PC) affects myocardial expression of TNC and ventricular remodeling using (125)I-labeled anti-TNC antibod...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-015-0100-8
更新日期:2015-04-02 00:00:00
abstract:BACKGROUND:The use of radiolabeled choline as a positron emission tomography (PET) agent for imaging primary tumors in the prostate has been evaluated extensively over the past two decades. There are, however, conflicting reports of its sensitivity and the relationship between choline PET imaging and disease staging is...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0269-0
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Targeted alpha therapy (TAT) offers advantages over current β-emitting conjugates for peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. PRRT with 177Lu-DOTATATE or 90Y-DOTATOC has shown dose-limiting nephrotoxicity due to radiopeptide retention in the proximal tubules. Pharmacological pr...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0240-5
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Fluorine-18 fluoroethoxybenzovesamicol ([18F]FEOBV) is a radioligand for the selective imaging of the vesicular acetylcholine transporter with positron emission tomography (PET). The current study demonstrates that pathological cortical cholinergic deafferentation can be quantified in vivo with [18F]FEOBV PE...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-3-70
更新日期:2013-10-09 00:00:00
abstract:BACKGROUND:Amyloid PET plays a vital role in detecting the accumulation of in vivo amyloid-β (Aβ). The quantification of Aβ accumulation has been widely performed using the region of interest (ROI)-based mean cortical standardized uptake value ratio (mcSUVR). However, voxel-based statistical analysis has not been well ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0561-2
更新日期:2019-09-18 00:00:00
abstract:BACKGROUND:Noninvasive preclinical imaging methodologies such as small animal positron emission tomography (PET) allow the repeated measurement of the same subject which is generally assumed to reduce the variability of the experimental outcome parameter and to produce more robust results. In this study, the variabilit...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-26
更新日期:2012-06-09 00:00:00
abstract:BACKGROUND:The kidneys are regarded as one of the main dose-limiting organs in the treatment of neuroendocrine tumours with (177)Lu-[DOTA(0), Tyr(3)]-octreotate ((177)Lu-octreotate), despite the successful use of kidney uptake blocking agents such as lysine and arginine. To avoid renal toxicity but still give each pati...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0059-x
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Radioembolization is an established treatment modality in colorectal cancer patients with liver-dominant disease in a salvage setting. Selection of patients who will benefit most is of vital importance. The aim of this study was to assess response (and mode of progression) at 3 months after radioembolization...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00697-z
更新日期:2020-09-22 00:00:00
abstract:BACKGROUND:Hepatobiliary scintigraphy using (99m)Tc-mebrofenin has been used as an investigation to study liver function after liver transplantation (LTx). Hepatic extraction fraction (HEF) is a measurement of the hepatic extraction efficiency and hepatic extraction rate. With the purpose of evaluating a possible diver...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0073-z
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:PET/CT with the radioactively labelled galactose analogue 2-18F-fluoro-2-deoxy-D-galactose (18F-FDGal) can be used to quantify the hepatic metabolic function and visualise regional metabolic heterogeneity. We determined the day-to-day variation in humans with and without liver disease. Furthermore, we examin...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0320-1
更新日期:2017-08-29 00:00:00
abstract:BACKGROUND:The biology of the vulnerable plaque includes increased inflammation and rapid growth of vasa vasorum, processes that are associated with enhanced vascular endothelial growth factor (VEGF)/ imaging receptors for VEGF (VEGFR) signaling and are accelerated in diabetes. This study was designed to test the hypot...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0041-7
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess the relationship of CT-perfusion (CTP), 18F-FDG-PET/CT and histological parameters, and the possible added value of CTP to FDG-PET/CT in the initial staging of lung cancer. METHODS:Fifty-four consecutive patients (median age 65 years, 15 females, 39 males) with suspec...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-4-6
更新日期:2014-01-22 00:00:00
abstract:BACKGROUND:The availability of GABAA receptor binding sites in the brain can be assessed by positron emission tomography (PET) using the radioligand, [18F]flumazenil. However, the brain uptake and binding of this PET radioligand are influenced by anesthetic drugs, which are typically needed in preclinical imaging studi...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0235-2
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:New therapies to treat diabetic peripheral artery disease (PAD) require target-specific non-invasive imaging modalities to follow efficacy. As a translational study, we performed targeted imaging of receptors for vascular endothelial growth factor (VEGF) in response to anterior femoral artery occlusion (FAO)...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00626-0
更新日期:2020-05-12 00:00:00
abstract:BACKGROUND:Vagus nerve activation impacts inflammation. Therefore, we hypothesized that vagal nerve stimulation (VNS) influenced arterial wall inflammation as measured by 18F-FDG uptake. RESULTS:Ten patients with left-sided VNS for refractory epilepsy were studied during stimulation (VNS-on) and in the hours after sti...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0567-9
更新日期:2019-11-27 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:EJNMMI research
pub_type: 已发布勘误
doi:10.1186/s13550-020-00719-w
更新日期:2020-10-27 00:00:00
abstract:BACKGROUND:Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor. Currently, 18F-fluoro-deoxy-glucose (18F-FDG) PET/CT is the functional imaging modality of choice. Few data are available on the use of 68Ga-somatostatin analogs. The aim of our study was to evaluate and compare the diagnostic performanc...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-018-0423-3
更新日期:2018-07-21 00:00:00
abstract:BACKGROUND:Tyrosine kinase inhibitors (TKIs) have experienced a tremendous boost in the last decade, where more than 15 small molecule TKIs have been approved by the FDA. Unfortunately, despite their promising clinical successes, a large portion of patients remain unresponsive to these targeted drugs. For non-small cel...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-015-0088-0
更新日期:2015-03-20 00:00:00
abstract:BACKGROUND:Bone Scan Index (BSI) is a quantitative measurement of tumour burden in the skeleton calculated from bone scan images. When analysed at the time of diagnosis, it has been shown to provide prognostic information on survival in men with metastatic prostate cancer (PCa). In this study, we evaluated the prognost...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0058-y
更新日期:2014-10-17 00:00:00
abstract:PURPOSE:We have developed a multi-modal imaging approach for SIRT, combining 99mTc-MAA SPECT/CT and/or 90Y PET, 18F-FDG PET/CT, and contrast-enhanced CBCT for voxel-based dosimetry, as a tool for treatment planning and verification. For radiation dose prediction calculations, a segmentation of the total liver volume an...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0485-x
更新日期:2019-02-20 00:00:00
abstract:BACKGROUND:Differentiated thyroid carcinoma (DTC) is the most common type of thyroid cancer. Treatment with surgery, radioactive iodine (RAI), and TSH suppression is effective in most patients. Five to 15% of patients become RAI refractory and need alternative therapy; however, treatment options are limited. 68Ga-PSMA ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-0610-x
更新日期:2020-03-06 00:00:00
abstract:BACKGROUND:The positron emission tomography (PET) ligand 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) targets the prostate-specific membrane antigen (PSMA), upregulated in prostate cancer cells. Although 68Ga-PSMA-11 PET is widely used in research and clinical practice, full kinetic modeling has not yet been reported ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-0594-6
更新日期:2020-02-24 00:00:00
abstract:BACKGROUND:There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during treatment and persisting metabolic activity after apparent clinical cure. This poses a challenge in quantifying scan-...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-0591-9
更新日期:2020-02-10 00:00:00
abstract:BACKGROUND:Prostate cancer is highly prevalent worldwide. Androgen deprivation therapy (ADT) remains the treatment of choice for incurable prostate cancer, but majority of patients develop disease recurrence following ADT. There is therefore an urgent need for early detection of treatment resistance. METHODS:Isogenic ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00728-9
更新日期:2020-11-25 00:00:00
abstract:BACKGROUND:18F-FDG-PET imaging has emerged as a promising method in the diagnosis of chronic osteomyelitis commonly due to Staphylococcus aureus. The inaccuracy of 18 F-FDG-PET in the detection of periprosthetic joint infections may be related to the predominance of low-virulent S. epidermidis strains as the causative ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-41
更新日期:2012-07-23 00:00:00
abstract:BACKGROUND:[18 F]fluorodopa (FDOPA) positron emission tomography (PET) allows assessment of levodopa (LDOPA) metabolism and is widely used to study Parkinson's disease. We examined how [18 F]FDOPA PET-derived kinetic parameters relate the dopamine (DA) and DA metabolite content of extracellular fluid measured by microd...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-3-69
更新日期:2013-10-02 00:00:00
abstract:BACKGROUND:Image-based measurement of absorbed dose of Ra-223 dichloride may be useful in predicting therapeutic outcome in patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to be more accurate than planar imaging in terms of lesion-based analysis. The aims of this study were t...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0330-z
更新日期:2017-10-03 00:00:00