dAcquisition setting optimization and quantitative imaging for 124I studies with the Inveon microPET-CT system.

abstract：BACKGROUND:Noninvasive preclinical imaging methodologies such as small animal positron emission tomography (PET) allow the repeated measurement of the same subject which is generally assumed to reduce the variability of the experimental outcome parameter and to produce more robust results. In this study, the variabilit...

journal_title：EJNMMI research

authors： Martic-Kehl MI,Ametamey SM,Alf MF,Schubiger PA,Honer M

更新日期：2012-06-09 00:00:00

abstract：BACKGROUND:Cerebral blood flow (CBF) quantitation using technetium-99m hexamethylpropyleneamine oxime (99mTc-HMPAO) generally requires assessment of input function by arterial blood sampling, which would be invasive for small animals. We therefore performed chest dynamic planar imaging, instead of arterial blood sampli...

journal_title：EJNMMI research

authors： Suzuki C,Kosugi M,Magata Y

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:Quantification of cerebral blood flow (CBF) is important for the understanding of normal and pathologic brain physiology. Positron emission tomography (PET) with H215O (or C15O2) can quantify CBF and apply kinetic analyses, including autoradiography (ARG) and the basis function methods (BFM). These approache...

journal_title：EJNMMI research

authors： Kudomi N,Maeda Y,Sasakawa Y,Monden T,Yamamoto Y,Kawai N,Iida H,Nishiyama Y

更新日期：2013-05-23 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess the relationship of CT-perfusion (CTP), 18F-FDG-PET/CT and histological parameters, and the possible added value of CTP to FDG-PET/CT in the initial staging of lung cancer. METHODS:Fifty-four consecutive patients (median age 65 years, 15 females, 39 males) with suspec...

journal_title：EJNMMI research

authors： Huellner MW,Collen TD,Gut P,Winterhalder R,Pauli C,Diebold J,Seifert B,Strobel K,Veit-Haibach P

更新日期：2014-01-22 00:00:00

abstract：PURPOSE:Chimeric antibody Miltuximab®, a human IgG1 engineered from the parent antibody MIL-38, is in clinical development for solid tumour therapy. Miltuximab® targets glypican-1 (GPC-1), a cell surface protein involved in tumour growth, which is overexpressed in solid tumours, including prostate cancer (PCa). This st...

journal_title：EJNMMI research

authors： Yeh MC,Tse BWC,Fletcher NL,Houston ZH,Lund M,Volpert M,Stewart C,Sokolowski KA,Jeet V,Thurecht KJ,Campbell DH,Walsh BJ,Nelson CC,Russell PJ

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:In contrast to ordered subset expectation maximization (OSEM), block sequential regularized expectation maximization (BSREM) positron emission tomography (PET) reconstruction algorithms can run until full convergence while controlling image quality and noise. Recent studies with BSREM and 18F-FDG PET reporte...

journal_title：EJNMMI research

authors： Ter Voert EEGW,Muehlematter UJ,Delso G,Pizzuto DA,Müller J,Nagel HW,Burger IA

更新日期：2018-07-27 00:00:00

abstract：: The classical attitude of Nuclear Medicine practitioners on matters of peptide-receptor interactions has maintained an intrinsic monogamic character since many years. New advances in the field of biochemistry and even in clinical Nuclear Medicine have challenged this type of thinking, which prompted me to work on thi...

journal_title：EJNMMI research

authors： Moncayo R

更新日期：2011-07-26 00:00:00

abstract：PURPOSE:To investigate the added value and diagnostic accuracy of 68Ga-PSMA PET/CT versus bone scintigraphy (BS) for bone metastasis detection at the primary staging of prostate cancer (PCa). METHODS:Inclusion criteria involved consecutive patients with newly diagnosed intermediate- to high-risk PCa, who had undergone...

journal_title：EJNMMI research

authors： Zacho HD,Ravn S,Afshar-Oromieh A,Fledelius J,Ejlersen JA,Petersen LJ

更新日期：2020-04-08 00:00:00

abstract：BACKGROUND:HEPES is a favorable buffer for 68Ga-complexations in radiochemical laboratories. The drawback of this buffer is its prescribed limit of 200 μg per recommended application volume in the final formulation. Currently, a TLC test according to the European Pharmacopoeia (Ph. Eur.) has to be performed for quantif...

journal_title：EJNMMI research

authors： Pfaff S,Nehring T,Pichler V,Cardinale J,Mitterhauser M,Hacker M,Wadsak W

更新日期：2018-10-23 00:00:00

abstract：BACKGROUND:Previously, we reported on the unexpected development of distant metastases in the subcutaneous rat pancreas CA20948 tumor model after 4.5 weeks of treatment with RAD001-only or in combination with [(177)Lu-DOTA(0),Tyr(3)]octreotate ((177)Lu-DOTATATE) (Cancer Res. 73:12-8, 2013). Moreover, the combination th...

journal_title：EJNMMI research

authors： Bison SM,Pool SE,Koelewijn SJ,van der Graaf LM,Groen HC,Melis M,de Jong M

更新日期：2014-05-30 00:00:00

abstract：BACKGROUND:Yoga is increasingly popular worldwide with several physical and mental benefits, but the underlying neurobiology remains unclear. Whereas many studies have focused on pure meditational aspects, the triad of yoga includes meditation, postures, and breathing. We conducted a cross-sectional study comparing exp...

journal_title：EJNMMI research

authors： van Aalst J,Ceccarini J,Schramm G,Van Weehaeghe D,Rezaei A,Demyttenaere K,Sunaert S,Van Laere K

更新日期：2020-05-14 00:00:00

abstract：BACKGROUND:Dosimetry in radionuclide therapy has the potential to allow for a treatment tailored to the individual patient. One therapeutic radiopharmaceutical where patient-specific dosimetry is feasible is 177Lu-DOTATATE, used for the treatment of neuroendocrine tumours. The emission of gamma photons by 177Lu allows ...

journal_title：EJNMMI research

authors： Gustafsson J,Sundlöv A,Sjögreen Gleisner K

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Depression in patients with brain tumors is associated with impaired quality of life and shorter survival. Altered metabolism of tryptophan to serotonin and kynurenine metabolites may play a role in tumor-associated depression. Our recent studies with alpha[(11)C]methyl-L-tryptophan (AMT)-PET in brain tumor ...

journal_title：EJNMMI research

authors： Bosnyák E,Kamson DO,Behen ME,Barger GR,Mittal S,Juhász C

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Peptide receptor radionuclide therapy (PRRT) is applied in patients with advanced neuroendocrine tumors. Co-infused amino acids (AA) should prevent nephrotoxicity. The aims of this study were to correlate the incidence of AA-induced hyperkalemia (HK) (≥5.0 mmol/l) and to identify predictors of AA-induced sev...

journal_title：EJNMMI research

authors： Lapa C,Werner RA,Bluemel C,Lueckerath K,Muegge DO,Strate A,Haenscheid H,Schirbel A,Allen-Auerbach MS,Bundschuh RA,Buck AK,Herrmann K

更新日期：2014-12-24 00:00:00

abstract：PURPOSE:Pathological complete response to the neoadjuvant therapy (NAT) for triple negative breast cancer (TNBC) is predictive of prolonged patient survival. Methods for early evaluation of NAT efficiency are still needed, in order to rapidly adjust the therapeutic strategy in case of initial non-response. One option f...

journal_title：EJNMMI research

authors： Jouberton E,Schmitt S,Chautard E,Maisonial-Besset A,Roy M,Radosevic-Robin N,Chezal JM,Miot-Noirault E,Bouvet Y,Cachin F

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:In order to better understand the concept of mechanical dyssynchrony, a promising hallmark of cardiac resynchronization therapy (CRT) response, we investigated its effect on regional myocardial metabolism and myocardial blood flow (MBF) in non-ischemic CRT candidates. RESULTS:Thirty consecutive non-ischemic...

journal_title：EJNMMI research

authors： Degtiarova G,Claus P,Duchenne J,Cvijic M,Schramm G,Nuyts J,Voigt JU,Gheysens O

更新日期：2019-12-09 00:00:00

abstract：BACKGROUND:177Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remission is rarely seen, and optimization of treatment protocols is needed. In vitro studies have shown that irradiation can up-regu...

journal_title：EJNMMI research

authors： Dalmo J,Spetz J,Montelius M,Langen B,Arvidsson Y,Johansson H,Parris TZ,Helou K,Wängberg B,Nilsson O,Ljungberg M,Forssell-Aronsson E

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Image-guided surgery may improve surgical outcome for colorectal cancer patients. Here, we evaluated the feasibility of a pretargeting strategy for multimodal imaging in colorectal cancer using an anti-carcinoembryonic antigen (CEA) x anti-histamine-succinyl-glycine (HSG) bispecific antibody (TF2) in conjunc...

journal_title：EJNMMI research

authors： Elekonawo FMK,Lütje S,Franssen GM,Bos DL,Goldenberg DM,Boerman OC,Rijpkema M

更新日期：2019-09-04 00:00:00

abstract：BACKGROUND:Erlotinib is an epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitor approved for treatment of non-small cell lung cancer. The wide inter-individual pharmacokinetic (PK) variability of erlotinib may impact treatment outcome and/or toxicity. Recent in vivo studies reported a nonlinear u...

journal_title：EJNMMI research

authors： Amor D,Goutal S,Marie S,Caillé F,Bauer M,Langer O,Auvity S,Tournier N

更新日期：2018-08-16 00:00:00

abstract：BACKGROUND:Non-small cell lung carcinoma (NSCLC) represents approximately 80% of lung cancer cases, and over 60% of these tumors express the epidermal growth factor receptor (EGFR). Activating mutations in the tyrosine kinase (TK) domain of the EGFR are detected in 10% to 30% of NSCLC patients, and evidence of their pr...

journal_title：EJNMMI research

authors： Abourbeh G,Itamar B,Salnikov O,Beltsov S,Mishani E

更新日期：2015-02-12 00:00:00

abstract：BACKGROUND:Two novel methods of image reconstruction, xSPECT Quant (xQ) and xSPECT Bone (xB), that use an ordered subset conjugate gradient minimizer (OSCGM) for SPECT/CT reconstruction have been proposed. The present study compares the performance characteristics of xQ, xB, and conventional Flash3D (F3D) reconstructio...

journal_title：EJNMMI research

authors： Miyaji N,Miwa K,Tokiwa A,Ichikawa H,Terauchi T,Koizumi M,Onoguchi M

更新日期：2020-06-29 00:00:00

abstract：BACKGROUND:Given the increasing clinical use of PET/MRI, potential risks to patients from simultaneous exposure to ionising radiation and (electro)magnetic fields should be thoroughly investigated as a precaution. With this aim, the genotoxic potential of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and a strong static m...

journal_title：EJNMMI research

authors： Brix G,Günther E,Rössler U,Endesfelder D,Kamp A,Beer A,Eiber M

更新日期：2020-04-28 00:00:00

abstract：BACKGROUND:Assessment of liver function is critical in hepatocellular carcinoma (HCC) patient management. We evaluated parameters of [(99m)Tc] sulfur colloid (SC) SPECT/CT liver uptake for association with clinical measures of liver function and outcome in HCC patients. METHODS:Thirty patients with HCC and variable Ch...

journal_title：EJNMMI research

authors： Bowen SR,Chapman TR,Borgman J,Miyaoka RS,Kinahan PE,Liou IW,Sandison GA,Vesselle HJ,Nyflot MJ,Apisarnthanarax S

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:To assess 18-fluorodeoxyglucose (FDG) bowel uptake in patients with differentiated thyroid cancer (DTC) treated with sorafenib. FINDINGS:Visual (5-point scale) and high maximum standard uptake value (SUVmax) semi-quantitative analyses were conducted in 63 positron emission tomography (PET) studies performed...

journal_title：EJNMMI research

authors： Ciappuccini R,Trzepla G,Heutte N,Sevin E,Galais MP,Bardet S

更新日期：2012-05-07 00:00:00

abstract：UNLABELLED: BACKGROUND:In single-photon emission computed tomography (SPECT), attenuation of photon flux in tissue affects quantitative accuracy of reconstructed images. Attenuation maps derived from X-ray computed tomography (CT) can be employed for attenuation correction. The attenuation coefficients as well as regi...

journal_title：EJNMMI research

authors： Wu C,Gratama van Andel HA,Laverman P,Boerman OC,Beekman FJ

更新日期：2013-01-31 00:00:00

abstract：BACKGROUND:Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC). METHODS:PVC was performed on 20 [18F] flortauci...

journal_title：EJNMMI research

authors： Wolters EE,Golla SSV,Timmers T,Ossenkoppele R,van der Weijden CWJ,Scheltens P,Schwarte L,Schuit RC,Windhorst AD,Barkhof F,Yaqub M,Lammertsma AA,Boellaard R,van Berckel BNM

更新日期：2018-08-15 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors (TKIs) have experienced a tremendous boost in the last decade, where more than 15 small molecule TKIs have been approved by the FDA. Unfortunately, despite their promising clinical successes, a large portion of patients remain unresponsive to these targeted drugs. For non-small cel...

journal_title：EJNMMI research

authors： Slobbe P,Windhorst AD,Stigter-van Walsum M,Smit EF,Niessen HG,Solca F,Stehle G,van Dongen GA,Poot AJ

更新日期：2015-03-20 00:00:00

abstract：BACKGROUND:We recently showed improved between-subject variability in our [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) experiments using a Michaelis-Menten transport model to calculate the metabolic tumor glucose uptake rate extrapolated to the hypothetical condition of glucose saturation: MRgl...

journal_title：EJNMMI research

authors： Williams SP,Flores-Mercado JE,Baudy AR,Port RE,Bengtsson T

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:Glioblastoma, the most frequent and aggressive of all astrocytomas, presents a clear predominance in male humans, but the assessment of sexual differences in its tumourigenesis and growth has received little attention so far. In this study, we aim to identify gender-dependent surrogate markers in an animal m...

journal_title：EJNMMI research

authors： Pérez-Carro R,Cauli O,López-Larrubia P

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Diacetyl-bis(N4-methylthiosemicarbazone), labeled with 64Cu (64Cu-ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various controversial studies highlighted potential pitfalls that may disable its use as a selective hypoxic marker. They also highlighted that the results may be tum...

journal_title：EJNMMI research

authors： Pérès EA,Toutain J,Paty LP,Divoux D,Ibazizène M,Guillouet S,Barré L,Vidal A,Cherel M,Bourgeois M,Bernaudin M,Valable S

更新日期：2019-12-19 00:00:00