abstract：:Icariin (ICA) has a significant capacity to protect against depression and hippocampal injury, but it cannot effectively cross the blood-brain barrier and accumulate in the brain. Therefore, the mechanism by which ICA protects against hippocampal injury in depression remains unclear. In this study, we performed proteo...

authors： Zeng NX,Li HZ,Wang HZ,Liu KG,Gong XY,Luo WL,Yan C,Wu LL

更新日期：2022-03-01 00:00:00

abstract：Background:Nature and intensity of physical activity may influence cognition, coping mechanisms and overall personality of an individual. The objective of this cross-sectional study was to compare cognition, coping styles and vedic personality among individuals practicing different lifestyle. Methods:Thirty-nine healt...

authors： Kaur H,Chaudhary S,Mohanty S,Sharma G,Kumaran SS,Ghati N,Bhatia R,Nehra A,Pandey RM

更新日期：2022-03-01 00:00:00

abstract：:Membrane phase separation to form micron-scale domains of lipids and proteins occurs in artificial membranes; however, a similar large-scale phase separation has not been reported in the plasma membrane of the living cells. We show here that a stable micron-scale protein-depleted region is generated in the plasma memb...

authors： Mioka T,Guo T,Wang S,Tsuji T,Kishimoto T,Fujimoto T,Tanaka K

更新日期：2022-03-01 00:00:00

abstract：:Transfer RNA (tRNA)-derived small RNAs (tsRNAs) are a recently established family of regulatory small non-coding RNAs that modulate diverse biological processes. Growing evidence indicates that tsRNAs are involved in neurological disorders and play a role in the pathogenesis of neurodegenerative disease. However, whet...

authors： Xu XJ,Yang MS,Zhang B,Ge QQ,Niu F,Dong JQ,Zhuang Y,Liu BY

更新日期：2022-02-01 00:00:00

abstract：:Brain stimulation techniques offer powerful means of modulating the physiology of specific neural structures. In recent years, non-invasive brain stimulation techniques, such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation, have emerged as therapeutic tools for neurology and neur...

authors： Uzair M,Abualait T,Arshad M,Yoo WK,Mir A,Bunyan RF,Bashir S

更新日期：2022-02-01 00:00:00

abstract：:[This corrects the article DOI: 10.4103/1673-5374.308073]. ...

authors：

更新日期：2022-02-01 00:00:00

abstract：:While many computational methods have been proposed for 3D chromosome reconstruction from chromosomal contact maps, these methods are rarely used for the interpretation of such experimental data, in particular Hi-C data. We posit that this is due to the lack of an easy-to-use implementation of the proposed algorithms,...

authors： Carron L,Morlot JB,Lesne A,Mozziconacci J

更新日期：2022-01-01 00:00:00

abstract：:Exosomes, a type of extracellular vesicle, are small vesicles (30-100 nm) secreted into extracellular space from almost all types of cells. Exosomes mediate cell-to-cell communication carrying various biologically active molecules including microRNAs. Studies have shown that exosomal microRNAs play fundamental roles i...

authors： Tastan B,Tarakcioglu E,Birinci Y,Park Y,Genc S

更新日期：2022-01-01 00:00:00

abstract：:Structural variations (SVs) are large genomic rearrangements that can be challenging to identify with current short read sequencing technology due to various confounding factors such as existence of genomic repeats and complex SV structures. Hi-C breakfinder is the first computational tool that utilizes the technology...

authors： Song F,Xu J,Dixon J,Yue F

更新日期：2022-01-01 00:00:00

abstract：:microRNAs (miRNAs) have recently been recognized as a new dimension of posttranscriptional regulation. It is well defined that most human protein-coding genes are regulated by one or more miRNAs. Therefore, it is crucial to identify genes targeted by the miRNAs to better understand their functions. Although bioinforma...

authors： Dedeoğlu BG,Noyan S

更新日期：2022-01-01 00:00:00

abstract：:Fast and effective detection of epidemics is the key to preventing the spread of diseases. In this work, we constructed a dual-wavelength ratiometric electrochemiluminescence (ECL) biosensor based on entropy-driven and bipedal DNA walker cycle amplification strategies for detection of the RNA-dependent RNA polymerase ...

authors： Fan Z,Yao B,Ding Y,Xu D,Zhao J,Zhang K

更新日期：2022-01-01 00:00:00

abstract：:The sensitivity of molecular diagnostics could be affected by nucleotide variants in pathogen genes, and the sites affected by such variants should be monitored. We report a single-nucleotide variant (SNV) in the nucleocapsid (N) gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), i.e., G29179T, whic...

authors： Hong KH,In JW,Lee J,Kim SY,Lee KA,Kim S,An Y,Lee D,Sung H,Kim JS,Lee H

更新日期：2022-01-01 00:00:00

abstract：:Excess extracellular glutamate leads to excitotoxicity, which induces neuronal death through the overactivation of N-methyl-D-aspartate receptors (NMDARs). Excitotoxicity is thought to be closely related to various acute and chronic neurological disorders, such as stroke and Alzheimer's disease. Polygalasaponin F (PGS...

authors： Sun C,Cao XC,Liu ZY,Ma CL,Li BM

更新日期：2022-01-01 00:00:00

abstract：:Parkinson's disease is the most common movement disorder worldwide, affecting over 6 million people. It is an age-related disease, occurring in 1% of people over the age of 60, and 3% of the population over 80 years. The disease is characterized by the progressive loss of midbrain dopaminergic neurons from the substan...

authors： Goulding SR,Anantha J,Collins LM,Sullivan AM,O'Keeffe GW

更新日期：2022-01-01 00:00:00

abstract：:During the current global public health emergency caused by novel coronavirus disease 19 (COVID-19), researchers and medical experts started working day and night to search for new technologies to mitigate the COVID-19 pandemic. Recent studies have shown that artificial intelligence (AI) has been successfully employed...

authors： Khan M,Mehran MT,Haq ZU,Ullah Z,Naqvi SR,Ihsan M,Abbass H

更新日期：2021-12-15 00:00:00

abstract：:Robotic lower-limb prostheses aim to replicate the power-generating capability of biological joints during locomotion to empower individuals with lower-limb loss. However, recent clinical trials have not demonstrated clear advantages of these devices over traditional passive devices. We believe this is partly because ...

authors： Huang HH,Si J,Brandt A,Li M

更新日期：2021-12-01 00:00:00

abstract：:Chemotherapeutic treatments are indispensable in the treatment of breast cancer. However, the emergence of multidrug-resistance, strong cell toxicity, and poor targeting selection has inhibited their clinical application. In this study, two synergistic drugs, doxorubicin (DOX) and curcumin (CUR), were co-administered ...

authors： Guo F,Yu N,Jiao Y,Hong W,Zhou K,Ji X,Yuan H,Wang H,Li A,Wang G,Yang G

更新日期：2021-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) play an important role in the development of prostate cancer (PCa). Recent studies have shown that miR-92a expression is significantly increased in various cancers including PCa. However, its specific mechanism in PCa remains unknown. The goal of this study was to investigate the effect of miR-92a e...

authors： Yanshen Z,Lifen Y,Xilian W,Zhong D,Huihong M

更新日期：2021-12-01 00:00:00

abstract：:Herein, we describe the development of a paper-based device to detect nucleic acids of pathogens of interest in complex samples using loop-mediated isothermal amplification (LAMP) by producing a colorimetric response visible to the human eye. To demonstrate the utility of this device in emerging public health emergenc...

authors： Davidson JL,Wang J,Maruthamuthu MK,Dextre A,Pascual-Garrigos A,Mohan S,Putikam SVS,Osman FOI,McChesney D,Seville J,Verma MS

更新日期：2021-12-01 00:00:00

abstract：:This study hoped to explore the effects and mechanism of long non-coding RNA (lncRNA) LUCAT1 regulating microRNA-181a-5p (miR-181a-5p) on oxidative stress and apoptosis of cardiomyocytes induced by H2O2. Totally, 72 patients with acute myocardial infarction (AMI) were included. H9c2 cardiomyocytes were cultured in vit...

authors： Xiao SH,Wang Y,Cao X,Su Z

更新日期：2021-12-01 00:00:00

abstract：Background:Due to the highly contagious innate of the novel coronavirus, the surgical team is exposed to the disease during surgical care of patient with confirmed covid-19. Therefore, the necessary measures should be taken to protect surgical caregivers. This study was conducted to determine the status of compliance w...

authors： Lotfi M,Sheikhalipour Z,Zamanzadeh V,Aghazadeh A,Zadi Akhuleh O

更新日期：2021-12-01 00:00:00

abstract：:Antiphospholipid syndrome (APS) is an autoimmune disease mainly characterised by vascular thrombosis and pregnancy morbidity. APS has broad spectrum of clinical manifestations. The digestive system involvement of antiphospholipid syndrome is a critical but under-recognised condition. Digestive system involvement may b...

authors： Zhang J,Li C,Han X,Chen Z,Adhikari BK,Wang Y,Wang Y,Sun J

更新日期：2021-12-01 00:00:00

abstract：:The methane-mitigating potency of cashew nutshell liquid (CNSL) was evaluated by investigating gas production from batch cultures using feces from Thai native ruminants that had been incubated for different periods. Feces was obtained from four Thai native cattle and four swamp buffaloes reared under practical feeding...

authors： Narabe C,Kamiyama S,Saito M,Boonsaen P,Khongpradit A,Sawanon S,Suzuki Y,Koike S,Kobayashi Y

更新日期：2021-12-01 00:00:00

abstract：:Asthma occurs accompanied by the ferroptosis in bronchial epithelial cells, during which Interleukin-6 (IL-6) plays a key role. However, the associations between IL-6, ferroptosis and asthma have not been reported. Bronchial epithelial cells BEAS-2B cells were induced by different concentrations of IL-6 and cell viabi...

authors： Han F,Li S,Yang Y,Bai Z

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Azacitidine (AZA) is the standard of care for higher-risk myelodysplastic syndrome (HR-MDS) patients ineligible for intensive therapy. Clinical outcome discrepancies reported in clinical trials and real-life settings stimulate the search for new prognostic factors. METHODS:We retrospectively evaluated 315 M...

authors： Mądry K,Lis K,Tukiendorf A,Szwedyk P,Kapelko-Słowik K,Subocz E,Gołos A,Makowska W,Masternak A,Kopińska A,Czemerska M,Zawadzka-Leska S,Rusicka P,Drozd-Sokołowska J,Wiater E,Hołojda J,Pogłódek B,Centkowski P,Waszczuk-Ga

更新日期：2021-12-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is one of the fatal tumors and is associated with a poor prognosis. Cell-type identification by estimating relative subsets of RNA transcripts (CIBERSORT) was used to quantify the proportions of 22 types of immune cells. Weighted gene co-expression network analysis (WGCNA) was establ...

authors： Chen B,Xie X,Lan F,Liu W

更新日期：2021-12-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Abnormal ovarian folliculogenesis is the main factor responsible for PCOS. Iron metabolism plays a vital role in endocrine disorder. This study aimed to investigate the potentials of iron metabolism in PCOS and the und...

authors： Zhang L,Wang F,Li D,Yan Y,Wang H

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:Synthetic biology has emerged from molecular biology and engineering approaches and aims to develop novel, biologically-inspired systems for industrial and basic research applications ranging from biocomputing to drug production. Surprisingly, redoxin (thioredoxin, glutaredoxin, peroxiredoxin) and other thio...

authors： Pillay CS,John N

更新日期：2021-12-01 00:00:00

abstract：:The solute carrier family has been reported to play critical roles in the progression of several cancers; however, the relationship between solute carrier family 12 member 8 (SLC12A8) and bladder cancer (BC) has not been clearly confirmed. This study explores the prognostic value of SLC12A8 for BC and its correlation ...

authors： Zhang Q,Liu Y,Chen P,Shi X,Liu Y,Shi L,Cong P,Mao S,Tong C,Du C,Hou M

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Skin, as a crucial external defense organ, is more vulnerable to oxidative stress (OS) insult, reactive oxygen species (ROS)-mediated OS in particular. OS results from a redox imbalance caused by various extrinsic stimuli and occurs once the oxidants production overwhelming the antioxidants capacity, through...

authors： Xian D,Guo M,Xu J,Yang Y,Zhao Y,Zhong J

更新日期：2021-12-01 00:00:00

abstract：:Kindlin-2 is a member of the FERM-containing cytoskeletal protein family that regulates cell-matrix interactions. Previous studies have shown that Kindlin-2 recruits focal adhesion proteins and regulates integration by binding to the focal adhesion region of the integrin β-segment. Although Kindlin-2 has been reported...

authors： Ying J,Wang Q,Lu L,Liu J,Guo R,Hu H,Jiang H,Qi F

更新日期：2021-12-01 00:00:00

abstract：:Ras-related Protein Rap1b, a GTP-binding protein belonging to the proximal RAS, which affects tumor progression through regulating tumor cell proliferation, invasion and participates in the functions of various immune cells. However, the potential roles and mechanisms of Rap1b in tumor progression and immunology remai...

authors： Cui G,Wang C,Lin Z,Feng X,Wei M,Miao Z,Sun Z,Wei F

更新日期：2021-12-01 00:00:00

abstract：PURPOSE:This review articulates current understanding of the aesthetic, artistic and creative contributions that Dance makes to Health and Wellbeing across the lifecourse within publications 2000-2019, an under-researched area. METHODS:Review Questions: What are the aesthetic, artistic and creative contributions that ...

authors： Chappell K,Redding E,Crickmay U,Stancliffe R,Jobbins V,Smith S

更新日期：2021-12-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is one of the main causes of death in the world. To improve the diagnostic level and find new biological targets，GSE datasets were selected from GEO databaseto analyze the differential expression genes and construct ceRNA network. Cell apoptosis detection showed that both the early a...

authors： Tang X,Wu Y,Yang J,Zhu W

更新日期：2021-12-01 00:00:00

abstract：:In the last two decades, water use has increased at twice the rate of population growth. The freshwater resources are getting polluted by contaminants like heavy metals, pesticides, hydrocarbons, organic waste, pathogens, fertilizers, and emerging pollutants. Globally more than 80% of the wastewater is released into t...

authors： Devda V,Chaudhary K,Varjani S,Pathak B,Patel AK,Singhania RR,Taherzadeh MJ,Ngo HH,Wong JWC,Guo W,Chaturvedi P

更新日期：2021-12-01 00:00:00

abstract：:MarvelD3, a recently identified tight junction membrane protein, could be associated with hepatocellular carcinoma (HCC). We aimed to investigate the role of marvelD3 in Epithelial-Mesenchymal Transition (EMT) and migration of HCC and explore the underlying molecular mechanisms. First, we assessed marvlD3 expression i...

authors： Li Y,Li T,Zhou D,Wei J,Li Z,Li X,Jia S,Ouyang Q,Qi S,Chen Z,Zhang B,Yu J,Jia J,Xu A,Huang J

更新日期：2021-12-01 00:00:00

abstract：:Little is known about how Talaromyces marneffei, a thermally dimorphic fungus that causes substantial morbidity and mortality in Southeast Asia, evades the human immune system. Polarization of macrophages into fungal-inhibiting M1-like and fungal-promoting M2-like types has been shown to play an important role in the ...

authors： Wei W,Ning C,Huang J,Wang G,Lai J,Han J,He J,Zhang H,Liang B,Liao Y,Le T,Luo Q,Li Z,Jiang J,Ye L,Liang H

更新日期：2021-12-01 00:00:00

abstract：:MicroRNA-mediated gene therapy is emerging as a promising method for the treatment of ovarian cancer, but the development of miRNA mimic delivery vectors is still in its infancy, where the safety and efficacy of miR-34a-mimic remain unknown. Ultrasound-targeted microbubble destruction (UTMD) can be an effective and mi...

authors： Li Y,Du M,Fang J,Zhou J,Chen Z

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:Multiple myeloma (MM) involves a clinically and biologically heterogeneous malignancy of plasma cells. It is difficult to predict the prognosis of MM. The presence of circulating clonal plasma cells (CPC) has been associated with a worse prognosis in patients with MM. METHODS:This study retrospectively anal...

authors： Han W,Jin Y,Xu M,Zhao SS,Shi Q,Qu X,Zhang R,Li J,Wu Y,Chen L

更新日期：2021-12-01 00:00:00

abstract：:Acinetobacter baumanniitriggers autophagy, affects the degradation of autophagy, and causes severe inflammatory injury. LncRNA growth arrest-specific transcript 5 (LncRNA-GAS5) and Yin and Yang 1 (YY1) are known to play an important role in the regulation of autophagy, however, the precise role of LncRNA-GAS5 and YY1 ...

authors： An Z,Ding W

更新日期：2021-12-01 00:00:00