Talaromyces marneffei promotes M2-like polarization of human macrophages by downregulating SOCS3 expression and activating the TLR9 pathway.

abstract：:Virulence and antibiotic resistance of the dangerous human pathogen Staphylococcus aureus are to large extent determined by the acquisition of mobile genetic elements (MGEs). Up to now, these elements were known to comprise either resistance or virulence determinants, but not a mixture of the two. Queck et al. now fou...

journal_title：Virulence

authors： Otto M

更新日期：2010-01-01 00:00:00

abstract：:Since tetanus was first described by Hippocrates, the devastating diseases caused by pathogenic members of the gram-positive, anaerobic sporeforming genus Clostridium have ranked among the most dreaded afflictions of humans and domestic animals. The quintessential hallmark of all clostridial diseases is the involvemen...

journal_title：Virulence

authors： McClane B

更新日期：2010-03-01 00:00:00

abstract：:Liquefaction is an important pathological process that can subsequently lead to cavitation where large numbers of bacilli can be coughed up which in turn causes spread of tuberculosis in humans. Current animal models to study the liquefaction process and to evaluate virulence of mycobacteria are tedious. In this study...

journal_title：Virulence

authors： Zhang G,Zhu B,Shi W,Wang M,Da Z,Zhang Y

更新日期：2010-05-01 00:00:00

abstract：:Virulence is thought to coevolve as a result of reciprocal selection between pathogens and their hosts. This paper focuses on coevolution between microbial proteinases operating as virulence factors and host defense molecules of insects. Owing to shorter generation times and smaller genomes, microbes exhibit a high ev...

journal_title：Virulence

authors： Vilcinskas A

更新日期：2010-05-01 00:00:00

abstract：:Abnormal expression of CEACAM6 is observed at the apical surface of the ileal epithelium in Crohn's disease (CD) patients, and CD ileal lesions are colonized by pathogenic adherent-invasive Escherichia coli (AIEC). The paper of Carvalho et al. recently reported that CD associated AIEC colonize and induce strong gut in...

journal_title：Virulence

authors： Barnich N,Darfeuille-Michaud A

更新日期：2010-07-01 00:00:00

abstract：:Intracellular pathogens like Salmonella, Mycobacteria and Listeria has several survival mechanisms to combat the host assault. One of the very interesting strategies observed in case of these intracellular bacteria is their ability to survive and replicate in specialized vacuole inside the infected cells. Salmonella, ...

journal_title：Virulence

authors： Lahiri A,Eswarappa SM,Das P,Chakravortty D

更新日期：2010-07-01 00:00:00

abstract：:In October 2009, we reported the first direct isolation of infectious xenotropic murine leukemia virus-related virus (XMRV). In that study, we used a combination of biological amplification and molecular enhancement techniques to detect XMRV in more than 75% of 101 patients with chronic fatigue syndrome (CFS). Since o...

journal_title：Virulence

authors： Mikovits JA,Lombardi VC,Pfost MA,Hagen KS,Ruscetti FW

更新日期：2010-09-01 00:00:00

abstract：:TAL effectors are important virulence factors of bacterial plant pathogenic Xanthomonas, which infect a wide variety of plants including valuable crops like pepper, rice, and citrus. TAL proteins are translocated via the bacterial type III secretion system into host cells and induce transcription of plant genes by bin...

journal_title：Virulence

authors： Scholze H,Boch J

更新日期：2010-09-01 00:00:00

abstract：:Despite considerable progress over recent years, the prognosis of invasive aspergillosis (IA) remains unfavorable, reflecting an incomplete understanding of Aspergillus pathogenesis and suboptimal antifungal efficacy in vivo. Mammalian host systems including rodents and rabbits are important tools in elucidating antif...

journal_title：Virulence

authors： Lionakis MS,Kontoyiannis DP

更新日期：2010-11-01 00:00:00

abstract：:In the preceding report, moderately lived-mice fed dietary 2-mercaptoethanol (2-Me) had their life extended, whereas long-lived mice were found to have the quality of life improved, but not extended, and did not develop high fat-diet obesity. In the present report, alteration of longevity of mice prone to develop spon...

journal_title：Virulence

authors： Click RE

更新日期：2010-11-01 00:00:00

abstract：:Epstein-Barr virus (EBV) latent infection promotes cell survival and proliferation, in some cases contributing to tumourigenesis. EBV-immortalized cells and EBV-induced tumours express the viral EBNA1 protein which, in addition to its roles in replicating and maintaining EBV genomes, can alter cellular processes, incl...

journal_title：Virulence

authors： Frappier L

更新日期：2011-01-01 00:00:00

abstract：:Bacterial pathogens detect and integrate multiple environmental signals to coordinate appropriate changes in gene expression including the selective expression of virulence factors, changes to metabolism and the activation of stress response systems. Mutations that abolish the ability of the pathogen to respond to ext...

journal_title：Virulence

authors： Zou SB,Roy H,Ibba M,Navarre WW

更新日期：2011-03-01 00:00:00

abstract：:Apoptosis is a regulated process of cell death originally described in multicelullar organisms contributing to their development and functionality. There is now increasing experimental evidence that a similar form of cell death is operative in unicellular eukaryotes, including trypanosomatids of the genera Trypanosoma...

journal_title：Virulence

authors： Smirlis D,Soteriadou K

更新日期：2011-05-01 00:00:00

abstract：:Malaria is a major public health problem affecting 500 million people each year. Only few anti-malarial drugs are now available for fighting this deadly disease, and their effectiveness is alarmingly dwindling because of the drug resistant strains. Here we discuss recent findings on the evolutionary process behind the...

journal_title：Virulence

authors： Chookajorn T,Kümpornsin K

更新日期：2011-05-01 00:00:00

abstract：:The research reported herein was designed to assess whether the bacterium, Dietzia subspecies C79793-74, used as a probiotic, could prevent development of parameters indicative of bovine paratuberculosis after potential in utero, birthing and neonatal (colostrum) exposure to Mycobacterium avium subspecies paratubercul...

journal_title：Virulence

authors： Click RE

更新日期：2011-07-01 00:00:00

abstract：:Two-component systems (TCSs) play important roles in the adaptation of bacteria to environmental changes and the regulation of virulence factor expression. In addition, the association of TCSs with susceptibility to antibacterial agents has been demonstrated in some bacterial species. Staphylococcus aureus, a major hu...

journal_title：Virulence

authors： Kawada-Matsuo M,Yoshida Y,Nakamura N,Komatsuzawa H

更新日期：2011-09-01 00:00:00

abstract：:There has been a continuous rise in the number of produce-based foodborne outbreaks in the recent decades despite the perception that foodborne diseases were primarily linked to animal-based products. The Centers for Disease Control and Prevention (CDC) estimates that 95% of Salmonella-based infections originate from ...

journal_title：Virulence

authors： Fatica MK,Schneider KR

更新日期：2011-11-01 00:00:00

abstract：:Over recent years we have witnessed the emergence of several non-vertebrate mini-hosts as alternative pathosystems for the study of fungal disease. These heterologous organisms have unique advantages, as they are economical, ethically expedient, and facile to use. Hence, they are amenable to high-throughput screening ...

journal_title：Virulence

authors： Lionakis MS

更新日期：2011-11-01 00:00:00

abstract：:Bacterial infections, like their viral counterparts, trigger the onset of innate immune defense mechanisms through the release of cytokines, including interferons (IFNs). While type I and II IFN responses to bacteria have long been explored, type III IFN response remains poorly addressed. We have recently reported tha...

journal_title：Virulence

authors： Lebreton A,Cossart P,Bierne H

更新日期：2012-01-01 00:00:00

abstract：:Cerebral malaria is the most severe pathology caused by the malaria parasite, Plasmodium falciparum. The pathogenic mechanisms leading to cerebral malaria are still poorly defined as studies have been hampered by limited accessibility to human tissues. Nevertheless, histopathology of post-mortem human tissues and mous...

journal_title：Virulence

authors： Rénia L,Howland SW,Claser C,Charlotte Gruner A,Suwanarusk R,Hui Teo T,Russell B,Ng LF

更新日期：2012-03-01 00:00:00

abstract：:Prevention and control of infectious diseases remains a major public health challenge and a number of highly virulent pathogens are emerging both in and beyond the hospital setting. Despite beneficial aspects such as use in biocontrol and bioremediation exhibited by members of the Burkholderia cepacia complex (Bcc) so...

journal_title：Virulence

authors： Tegos GP,Haynes MK,Schweizer HP

更新日期：2012-05-01 00:00:00

abstract：:It has been proposed that intracellular pathogens may interfere with expression or function of proteins that mediate vesicular traffic in order to survive inside cells. Brucella melitensis is an intracellular pathogen that evades phagosome-lysosome fusion, surviving in the so-called Brucella-containing vacuoles (BCV)....

journal_title：Virulence

authors： Castañeda-Ramírez A,Puente JL,González-Noriega A,Verdugo-Rodríguez A

更新日期：2012-08-15 00:00:00

abstract：:Nine individuals with ulcerative colitis or Crohn disease grew up or lived in Plains, Montana, a 1,200-person community adjacent to the Clark Fork River near herds of free ranging Rocky Mountain bighorn sheep. This inflammatory bowel disease outbreak is similar to others that have occurred along rivers contaminated by...

journal_title：Virulence

authors： Pierce ES

更新日期：2012-10-01 00:00:00

abstract：:Streptococcus pyogenes (GAS) is a human pathogen that causes multiple infections worldwide. The pathogenic properties of GAS strains are often linked to the production of virulence factors such as toxins, proteases or DNases. Detection of virulence factors produced by GAS strains can be used to either determine pathog...

journal_title：Virulence

authors： Borek AL,Obszańska K,Hryniewicz W,Sitkiewicz I

更新日期：2012-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a small, enveloped RNA virus and a major cause of chronic liver disease. Resolution of primary HCV infections depends upon the vigorous responses of CD4⁺ and CD8⁺ T cells to multiple viral epitopes. Although such broad-based responses are readily detected early during the course of infection...

journal_title：Virulence

authors： Losikoff PT,Self AA,Gregory SH

更新日期：2012-11-15 00:00:00

abstract：:Dendritic cells (DC) are a heterogeneous population of innate immune cells that are fundamental to initiating responses against invading pathogens and regulating immune responses. Myeloid DC (mDC) act as a bridge between the innate and adaptive immune response during virus infections but their role in immunity to huma...

journal_title：Virulence

authors： Wonderlich ER,Barratt-Boyes SM

更新日期：2012-11-15 00:00:00

abstract：:The application of advanced imaging techniques to fundamental questions in immunology has provided insight into dendritic cell function and has challenged dogma created using static imaging of lymphoid tissue. The history of dendritic cell biology has a storied past and is tightly linked to imaging. The development of...

journal_title：Virulence

authors： Vyas JM

更新日期：2012-11-15 00:00:00

abstract：:Due to a significant decrease in the cost of DNA sequencing, the number of sequences submitted to the public databases has dramatically increased in recent years. Efficient analysis of these data sets may lead to a significant understanding of the nature of pathogens such as bacteria, viruses, parasites, etc. However,...

journal_title：Virulence

authors： Munir M

更新日期：2013-01-01 00:00:00

abstract：:Over the last years, an intensive worldwide effort is speeding up the developments in the establishment of a global surveillance network for combating pandemics of emergent and re-emergent infectious diseases. Scientists from different fields extending from medicine and molecular biology to computer science and applie...

journal_title：Virulence

authors： Siettos CI,Russo L

更新日期：2013-05-15 00:00:00

abstract：:The immune response to sepsis can be seen as a pattern recognition receptor-mediated dysregulation of the immune system following pathogen invasion in which a careful balance between inflammatory and anti-inflammatory responses is vital. Invasive infection triggers both pro-inflammatory and anti-inflammatory host resp...

journal_title：Virulence

authors： Wiersinga WJ,Leopold SJ,Cranendonk DR,van der Poll T

更新日期：2014-01-01 00:00:00