UTMD promoted local delivery of miR-34a-mimic for ovarian cancer therapy.

abstract：:The penetration into the stratum corneum of fluorescein, as the acid form or as a sodium salt, encapsulated in liposomes formed by liquid- or gel-state phospholipids, with or without cholesterol, was investigated in humans by the stripping method. Liposomes prepared by extrusion were applied to the forearms of healthy...

journal_title：Drug delivery

authors： Pérez-Cullell N,Coderch L,de la Maza A,Parra JL,Estelrich J

更新日期：2000-01-01 00:00:00

abstract：:The aim of this work was to test in vivo a new block copolymer-based delivery system containing lipophilic drug FK506, known as Tacrolimus. Tacrolimus is currently used in clinics as an immunosupressant agent, and more recently it has been shown that it can exert neurotrophic effects. We prepared, characterized, and a...

journal_title：Drug delivery

authors： Allen C,Eisenberg A,Mrsic J,Maysinger D

更新日期：2000-07-01 00:00:00

abstract：:A drug-loaded tumor cell (DLTC) system has been developed for lung metastasis-targeting drug delivery. Doxorubicin was loaded into B16-F10 murine melanoma cells (96 microg/10(6) cells). The loading process led to the death of all the carrier cells. The diameter of DLTC was 15.03+/-2.36 microm (mean +/- SD). The amount...

journal_title：Drug delivery

authors： Shao J,DeHaven J,Lamm D,Weissman DN,Runyan K,Malanga CJ,Rojanasakul Y,Ma JK

更新日期：2001-04-01 00:00:00

abstract：:As a potent drug carrier for systemic fungal infections, amphotericin B(AmB)-phospholipid composite particles (APCPs) were prepared by the spray drying method. AmB and egg phosphatidylcholine, co-dissolved in methanol (0.0425-0.45 mg AmB/ml, 0.17-1.8 mg lipid/ml), was nebulized at 2 ml/min. The aerosol produced was ca...

journal_title：Drug delivery

authors： Kim JC,Kim JD

更新日期：2001-07-01 00:00:00

abstract：:This article describes a novel, simple, and relatively inexpensive method to prepare cationic liposomes using an ethanol injection/pressure extrusion method. The study also demonstrated that binding erythrosine dye to cationic liposomes results in a shift of the absorption maximum of the dye from 528 nm to 549 nm at p...

journal_title：Drug delivery

authors： Dass CR,Walker TL,Burton MA

更新日期：2002-01-01 00:00:00

abstract：:Oligodeoxynuclotides (ODNs) are deoxyribonucleic-acid-based sequences showing therapeutic potential against such diseases as cancer, arteriosclerosis, arthritis, viral infections, and inflammation. Administration of these chemical entities using carriers has certain advantages over administration of free nucleic acid ...

journal_title：Drug delivery

authors： Dass CR

更新日期：2002-07-01 00:00:00

abstract：:Controlled drug delivery from micelles requires that the micelles remain stable when diluted below their critical micelle concentration, such as upon injection into blood. A cross-linked, interpenetrating network of N,N-diethylacrylamide (NNDEA) was polymerized in the core of Pluronic P105 micelles to stabilize tempor...

journal_title：Drug delivery

authors： Pruitt JD,Pitt WG

更新日期：2002-10-01 00:00:00

abstract：:The aim of our study is to assess the release characteristics, in vitro permeation, and stability of an enteric-coated, bioadhesive, sustained-release formulation of didanosine (ddI). Enteric-coated tablets of ddI, containing Polyox WSRN-303 and Methocel K4M, were prepared using hydroxypropylmethylcellulose phthalate ...

journal_title：Drug delivery

authors： Deshmukh D,Ravis WR,Betageri GV

更新日期：2003-01-01 00:00:00

abstract：:Carboplatin (CPt) was incorporated into nonphospholipid vesicles (NPLV) by the method of membrane dispersion and its content determined spectrophotometrically. The particle size was between 2.0-10.0 microm with a mean value of 3.26 microm and a span of 0.55; and the drug content was 3.965 mg/ml. Dynamic dialysis was u...

journal_title：Drug delivery

authors： Lu B,Zhang JQ,Yang H

更新日期：2003-04-01 00:00:00

abstract：:This article describes the production and characterization of cationic microparticles based on pullulan and starch for the delivery of nucleic acids. The microparticles were prepared by chemically cross-linkinking of a polymer solution dispersed in organic phase, followed by amination with N, N-diethyl-2-chloroethyl a...

journal_title：Drug delivery

authors： Constantin M,Fundueanu G,Cortesi R,Esposito E,Nastruzzi C

更新日期：2003-07-01 00:00:00

abstract：:The new concept developed in this study is the preparation of a new derivative of erythrocyte ghosts, i.e., membrane vesicles loaded with doxorubicin (Dox) HCl and coupled to folic acid to improve cancer chemotherapy. N-hydroxysuccinimide (NHS) folate was then conjugated to membrane vesicles. These membrane vesicles w...

journal_title：Drug delivery

authors： Mishra PR,Jain NK

更新日期：2003-10-01 00:00:00

abstract：:Two CPT-SSA conjugates, JF-10-71 and JF-10-81, containing a chemically adjustable release-rate carbamate linker, have been reported previously by us to potently inhibit growth of human neuroblastoma IMR32 cells overexpressing somatostatin receptor type II (SSTR2) but are stable under buffer incubation conditions or in...

journal_title：Drug delivery

authors： Sun L,Fuselier JA,Coy DH

更新日期：2004-07-01 00:00:00

abstract：:The purpose of this study was to investigate the nasal absorption of insulin from a carbopol-based nasal gel spray in rabbits. An insulin nasal gel was prepared by dispersing carbopol in distilled water, followed by the addition of insulin solution, then neutralization and viscosity adjustment. The nasal absorption of...

journal_title：Drug delivery

authors： Najafabadi AR,Moslemi P,Tajerzadeh H

更新日期：2004-09-01 00:00:00

abstract：:Polyethylene glycol (PEG)ylated (stealth) immunoliposomes directed against human gliofibrillary acidic protein (GFAP) were prepared by coupling the thiolated monoclonal anti-GFAP antibodies with a maleimide derivative of phosphatidyl ethanolamine of the liposomal membrane. Experiments with cell cultures demonstrated s...

journal_title：Drug delivery

authors： Chekhonin VP,Zhirkov YA,Gurina OI,Ryabukhin IA,Lebedev SV,Kashparov IA,Dmitriyeva TB

更新日期：2005-01-01 00:00:00

abstract：:Poly [bi(o-carboxyphenyl)adipate-polyethylene glycol] anhydrides--P(BOCA-PEG)--polymeric drugs were synthesized and characterized by Fourier transformed infrared spectroscopy, NMR, DSC, gel permeation chromatography, etc. Salicylic acid loading efficiency of these polymers ranged from 43.5% to 71.3%, which was much hi...

journal_title：Drug delivery

authors： Cai Q,Zhu KJ,Zhang J

更新日期：2005-03-01 00:00:00

abstract：:Using citronellal as a model compound, pectin gels formulations were evaluated for the controlled fragrance release by kinetic and static methods. The pectins with higher degrees of esterification induced a stronger molecular association with the nonpolar fragrance. This resulted in a prolonged duration of fragrance r...

journal_title：Drug delivery

authors： Liu L,Chen G,Fishman ML,Hicks KB

更新日期：2005-05-01 00:00:00

abstract：:A polysaccharide hydrogel was isolated from the seeds of Tamarindus indica (tamarind) and was used as release modifier for the preparation of diclofenac sodium spheroids, using extrusion-spheronization technique. The process was studied for the effect of variables to arrive at spheroids with satisfactory particle shap...

journal_title：Drug delivery

authors： Kulkarni GT,Gowthamarajan K,Dhobe RR,Yohanan F,Suresh B

更新日期：2005-07-01 00:00:00

abstract：:Drug treatment of pulmonary hypertension may be limited by systemic hypotension. Selective action of a vasodilator drug in pulmonary arteries could be achieved by administering a vasodilator gas into systemic venous blood so that it dilates pulmonary arteries before immediate first-pass elimination via exhalation. Thi...

journal_title：Drug delivery

authors： Yeager MP,Clark JA,Yeager SB

更新日期：2005-09-01 00:00:00

abstract：:Solid lipid nanoparticles (SLNs) containing tamoxifen, a nonsteroidal antiestrogen used in breast cancer therapy, were prepared by microemulsion and precipitation techniques. Tamoxifen loaded SLNs seem to have dimensional properties useful for parenteral administration, and in vitro plasmatic drug release studies demo...

journal_title：Drug delivery

authors： Fontana G,Maniscalco L,Schillaci D,Cavallaro G,Giammona G

更新日期：2005-11-01 00:00:00

abstract：:Environmentally responsive gel formulation for ocular controlled delivery of carteolol hydrochloride (HCl) was developed in an attempt to improve ocular bioavailability and hence decrease its systemic absorption and side effects. The viscosity and the ability of the prepared formulations to deliver carteolol HCl in vi...

journal_title：Drug delivery

authors： El-Kamel A,Al-Dosari H,Al-Jenoobi F

更新日期：2006-01-01 00:00:00

abstract：:To show the possibility of sustained-release insulin formulation composed of PLGA, the optimum one was administered to BioBreeding rat, a model of spontaneous type I diabetes mellitus (IDDM). Every 2 weeks subcutaneous administration made their blood glucose level depend on the insulin release and food intake. However...

journal_title：Drug delivery

authors： Takenaga M,Yamaguchi Y,Ogawa Y,Kitagawa A,Kawai S,Mizushima Y,Igarashi R,Namae M,Komeda K

更新日期：2006-03-01 00:00:00

abstract：:The purpose of our work was to develop an ophthalmic delivery system of a flouroquinolone antibiotic, pefloxacin mesylate, based on the concept of ion-activated in situ gelation. Gelrite gellan gum, a novel ophthalmic vehicle, that gels in the presence of mono- or divalent-cations present in the lacrimal fluid, was us...

journal_title：Drug delivery

authors： Sultana Y,Aqil M,Ali A

更新日期：2006-05-01 00:00:00

abstract：:Polyethylene glycol (PEG) derivatives of ibuprofen were prepared by esterification of PEG monosuccinate with hydroxy ethyl ester (HEE), hydroxy ethylamide (HEA), and hydroxy ethyl thioester (HET) of ibuprofen. Hydrolysis of HEE-PEG, HEA-PEG, and HET-PEG were studied in vitro with or without esterases to investigate th...

journal_title：Drug delivery

authors： Davaran S,Rashidi MR,Hanaee J,Hamidi AA,Hashemi M

更新日期：2006-09-01 00:00:00

abstract：:For emergency contraceptive, the rapid delivery of levonorgestrel (LNG) to plasma is desirable, furthermore, a sustained delivery of LNG along with rapid absorption will be necessary. The pharmacokinetics and pharmacodynamics of LNG entrapped in different kinds of liposome formulations via nasal administration in rats...

journal_title：Drug delivery

authors： Ding WX,Qi XR,Fu Q,Piao HS

更新日期：2007-02-01 00:00:00

abstract：:pH-sensitive hydrogels are suitable candidates for oral delivery of therapeutic peptides, proteins, and drugs, due to their ability to respond to environmental pH changes. New pH-sensitive glycopolymers have been developed by free-radical polymerization of methacrylic acid and 6-acryloyl-glucose-1, 2, 3, 4-tetraacetat...

journal_title：Drug delivery

authors： Mahkam M

更新日期：2007-03-01 00:00:00

abstract：:The preparation of an osmotic pump tablet was simplified by elimination of laser drilling using prazosin hydrochloride as the model drug. The osmotic pump system was obtained by coating the indented core tablet compressed by the punch with a needle. A multiple regression equation was achieved with the experimental dat...

journal_title：Drug delivery

authors： Liu L,Wang J,Zhu S

更新日期：2007-04-01 00:00:00

abstract：:Plasmid-based gene delivery to muscle is a treatment strategy for many diseases with potential advantages above viral-based gene delivery methods, however, with a relative low transfection efficiency. We compared two physical methods - electroporation and ultrasound - that facilitate DNA uptake into cells. Mice (C57Bl...

journal_title：Drug delivery

authors： Kusumanto YH,Mulder NH,Dam WA,Losen M,De Baets MH,Meijer C,Hospers GA

更新日期：2007-07-01 00:00:00

abstract：:Osteomyelitis is an inflammatory bone disease caused by pyogenic bacteria. The advantages of localized biodegradable therapy for osteomyelitis include high local antibiotic concentration at the site of infection and obviation of the need for removal of the implant after treatment. The purpose of this study was to deve...

journal_title：Drug delivery

authors： El-Kamel AH,Baddour MM

更新日期：2007-08-01 00:00:00

abstract：:Hard gelatin capsule was coated by a cellulose acetate as a semipermeable membrane with or without castor oil and filled with propranolol hydrochloride and sorbitol as an osmotic agent. After sealing the capsule with white bees wax plug, the onset of release and dissolution rate of the drug were studied. Water penetra...

journal_title：Drug delivery

authors： Barzegar-Jalali M,Adibkia K,Mohammadi G,Zeraati M,Bolagh BA,Nokhodchi A

更新日期：2007-10-01 00:00:00

abstract：:Diclofenac sodium tablets consisting of core coated with two layers of swelling and rupturable coatings were prepared and evaluated as a pulsatile drug delivery system. Cores containing the drug were prepared by direct compression using microcrystalline cellulose and Ludipress as hydrophilic excipients with the ratio ...

journal_title：Drug delivery

authors： El-Maradny HA

更新日期：2007-11-01 00:00:00