The digestive system involvement of antiphospholipid syndrome: pathophysiology, clinical characteristics, and treatment strategies.

abstract：:The impact of vaccination on the health of the world's peoples has been considerable. With the possible exception of clean water, no other development has had such a major effect on the reduction of mortality and on population growth. During the last 200 years, vaccination has controlled nine major diseases and has le...

journal_title：Annals of medicine

authors： Dorner F,Barrett PN

更新日期：1999-02-01 00:00:00

abstract：:This paper addresses the questions of whether early nutritional experience affects later somatic growth, the growth of the adipose tissue, or the levels of serum lipids among well-nourished children. The analyses are based on data from three prospective studies. Postnatal nutrition and growth: there were differences i...

journal_title：Annals of medicine

authors： Boulton TJ,Garnett SP,Cowell CT,Baur LA,Magarey AM,Landers MC

更新日期：1999-04-01 00:00:00

abstract：:Compared with our understanding of the electrophysiological correlates of sleep and wakefulness, the search for correlates at the molecular level is still in its infancy. However, the evidence obtained so far supports the hypothesis that reliable molecular correlates do exist. As will be summarized in this review, lev...

journal_title：Annals of medicine

authors： Cirelli C,Tononi G

更新日期：1999-04-01 00:00:00

abstract：:The incidence of ectopic pregnancy showed a sharp increase in the industrialized countries in the late 1970s. This resulted in an epidemic of ectopic pregnancy in the 1980s. At present the incidence of ectopic pregnancy has levelled off or even decreased. In the meantime the diagnosis of ectopic pregnancy has improved...

journal_title：Annals of medicine

authors： Mäkinen J

更新日期：1999-06-01 00:00:00

abstract：:In spite of recent advances in secondary prevention, sudden cardiac death has remained a major public health problem as the majority of fatalities occur in subjects without a history of severe heart disease. Abrupt rupture of a vulnerable plaque resulting in thrombotic occlusion of a coronary artery is a common cause ...

journal_title：Annals of medicine

authors： Airaksinen KE

更新日期：1999-08-01 00:00:00

abstract：:The effects of thymic hormones are not restricted within the immune system but are rather pleiotropic. Through neuropeptides the neuroendocrine system participates in the regulation of homeostasis as well as in the control of stress response and behavioural outputs. Thymic hormones increase spontaneous behaviour, inhi...

journal_title：Annals of medicine

authors： Lempereur L,Cantarella G,Murabito P,Chiarenza A,Fiore L,Zappalà G,Bernardini R

更新日期：1999-10-01 00:00:00

abstract：:Arginine, taurine and homocysteine are amino acids which have been shown to affect the risk factors of cardiovascular diseases in humans. Arginine and taurine may protect against cardiovascular diseases while homocysteine may be a risk factor for them. Both arginine and taurine seem to lower blood pressure, arginine m...

journal_title：Annals of medicine

authors： Nittynen L,Nurminen ML,Korpela R,Vapaatalo H

更新日期：1999-10-01 00:00:00

abstract：:Coeliac disease, a life-long gluten-sensitive disorder, characterized by malabsorption, villous atrophy and crypt hyperplasia, is well recognized. However, the disease is evidently underdiagnosed, and the classic forms constitute only the tip of the 'coeliac iceberg'. Patients with coeliac disease can have subtle symp...

journal_title：Annals of medicine

authors： Collin P

更新日期：1999-12-01 00:00:00

abstract：:Caenorhabditis elegans is now the model organism of choice for a growing number of researchers. A combination of its apparent simplicity, exquisite genetics, the existence of a full molecular toolkit and a complete genome sequence makes it ideal for rapid and effective study of gene function. A survey of the C. elegan...

journal_title：Annals of medicine

authors： Aboobaker AA,Blaxter ML

更新日期：2000-02-01 00:00:00

abstract：:Pharmacogenetic research into neurotransmitter-related genes is helping to unravel genetic factors that determine antipsychotic response. Several genetic mutations in neurotransmitter receptors targeted by antipsychotic drugs have been found to be related to clinical response. Modern molecular genetic techniques will ...

journal_title：Annals of medicine

authors： Arranz MJ,Kerwin RW

更新日期：2000-03-01 00:00:00

abstract：:Febrile seizures are the most common convulsive events in childhood occurring in 2-5 % of children. 20-30% of these children will have a recurrence during a subsequent febrile infection. Even though the outcome of febrile seizures is benign, the possibility of recurrences keeps most families in fear for years after th...

journal_title：Annals of medicine

authors： Rantala H,Tarkka R,Uhari M

更新日期：2000-04-01 00:00:00

abstract：:C-reactive protein (CRP) is an ancient highly conserved molecule and a member of the pentraxin family of proteins. CRP is secreted by the liver in response to a variety of inflammatory cytokines. Levels of CRP increase very rapidly in response to trauma, inflammation, and infection and decrease just as rapidly with th...

journal_title：Annals of medicine

authors： Du Clos TW

更新日期：2000-05-01 00:00:00

abstract：:Both environmental and predispositional factors are of importance in the pathogenesis of cardiovascular (CV) disease. In humans, it is difficult to characterize the pathogenic environmental factors (exposures) because of the long time-span of pathogenesis. Perceived effort, control, social isolation, and absence of re...

journal_title：Annals of medicine

authors： Knardahl S

更新日期：2000-07-01 00:00:00

abstract：:Evidence is accumulating in support of the plausible notion that lower arterial elasticity is associated with an increased risk of cardiovascular disease manifestations. Conventional indices of arterial stiffness are compared to a newer method (blood pressure-adjusted pulsatile arterial diameter change) in terms of bl...

journal_title：Annals of medicine

authors： Liao D

更新日期：2000-09-01 00:00:00

abstract：:The recent development of noninvasive techniques to measure airway inflammation has led to the recognition of eosinophilic bronchitis, a condition characterized by a sputum eosinophilia identical to that seen in asthma, but without any of the functional abnormalities associated with asthma. The condition is interestin...

journal_title：Annals of medicine

authors： Brightling CE,Pavord ID

更新日期：2000-10-01 00:00:00

abstract：:Platelets play a pivotal role in the pathophysiology of unstable angina, acute myocardial infarction, and complications following percutaneous coronary intervention. Three classes of platelet-inhibiting drugs, aspirin, thienopyridines and platelet glycoprotein IIb/ IIIa inhibitors, are now commonly used for the preven...

journal_title：Annals of medicine

authors： Van De Graaff E,Steinhubl SR

更新日期：2000-11-01 00:00:00

abstract：:The mutant prevention concentration (MPC) is a new measure of antibiotic potency above which a microbe must attain two concurrent resistance mutations for growth. For some C-8-methoxy fluoroquinolone-pathogen combinations, the value of MPC is below human serum drug concentration achieved with standard doses. Although ...

journal_title：Annals of medicine

authors： Drlica K

更新日期：2000-12-01 00:00:00

abstract：:Several single-nucleotide polymorphisms (SNPs) of platelet receptors have been implicated to be associated with an increased risk of arterial thrombosis; this review focuses on the mechanisms and the clinical significance of two specific single-nucleotide polymorphisms, ie the GP IIIa L33P (=PlA1/2) and the GP Ia 807 ...

journal_title：Annals of medicine

authors： Beer JH,Pederiva S,Pontiggia L

更新日期：2000-12-01 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT), a drug-induced immunohaematological adverse reaction, is a rare but potentially very severe condition. The main problem for this complex syndrome is its recognition and management, which should be as early as possible to avoid the development of life-threatening complications. M...

journal_title：Annals of medicine

authors： Elalamy I,Lecrubier C,Horellou MH,Conard J,Samama MM

更新日期：2000-12-01 00:00:00

abstract：:Otitis media with effusion (OME) is a common condition that can cause deafness as well as speech and behavioural disturbance. It has long been considered to be a noninfective process resulting from Eustachian tube dysfunction; however, molecular biological techniques have implicated bacteria in the aetiology of this c...

journal_title：Annals of medicine

authors： Fraise AP,Pahor AL,Beswick AJ

更新日期：2001-02-01 00:00:00

abstract：:The mammalian cell cycle is exquisitely controlled by a 'machinery' composed of cyclin-dependent kinases and their binding partners, the cyclins. These kinases regulate transitions into DNA synthesis and mitosis, and their inactivity contributes to cellular quiescence, differentiation and senescence. Cell cycle transi...

journal_title：Annals of medicine

authors： McDonald ER 3rd,El-Deiry WS

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Cartilage-hair hypoplasia (CHH), an autosomal recessive chondrodysplasia, is characterized by severe growth failure, hypoplastic hair, impaired immunity, and deficient erythropoiesis. These features may result from a generalized defect in cell proliferation. AIM:In order to investigate whether an impairment...

journal_title：Annals of medicine

authors： Mäkitie OM,Tapanainen PJ,Dunkel L,Siimes MA

更新日期：2001-04-01 00:00:00

abstract：:Decreased right ventricle (RV) output results in decreased left ventricle end-diastolic volume (LVEDV) and output by series interaction. Direct ventricular interaction may also have a major effect on LV function. Thus, decreased LVEDV caused by reduced RV output may be further reduced by a leftward septal shift and pe...

journal_title：Annals of medicine

authors： Belenkie I,Smith ER,Tyberg JV

更新日期：2001-05-01 00:00:00

abstract：:The RAND-36 is perhaps the most widely used health-related quality of life (HRQoL) survey instrument in the world today. It is comprised of 36 items that assess eight health concepts: physical functioning, role limitations caused by physical health problems, role limitations caused by emotional problems, social functi...

journal_title：Annals of medicine

authors： Hays RD,Morales LS

更新日期：2001-07-01 00:00:00

abstract：:There is a rapidly accumulating body of evidence from family, adoption and twin studies suggestive of a genetic component to many common mental disorders. In some cases, the transmission of abnormalities has been shown to be dependent upon the sex of the parent from whom they are inherited. Such 'parent-of-origin effe...

journal_title：Annals of medicine

authors： Davies W,Isles AR,Wilkinson LS

更新日期：2001-09-01 00:00:00

abstract：:Parechoviruses are a recently established group of human viral pathogens. At the time of their first isolation, parechoviruses were classified among the enterovirus genus in the picornavirus family, but based on their different biological properties they were separated into their own genus. The type member is human pa...

journal_title：Annals of medicine

authors： Joki-Korpela P,Hyypiä T

更新日期：2001-10-01 00:00:00

abstract：:This paper concentrates on the genetic aspects of pulmonary arterial hypertension (PAH), a diagnostically based subclass of pulmonary hypertension that includes primary pulmonary hypertension (PPH). During the past year, patients with familial and sporadic PPH were found to have germline heterozygous missense, nonsens...

journal_title：Annals of medicine

authors： Morse JH,Deng Z,Knowles JA

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:There is increasing evidence that oxidation of low-density lipoprotein (LDL) plays an important role in atherogenesis. AIM:To explore the LDL oxidizability and its determinants in familial combined hyperlipidemia (FCHL) patients with different phenotypes. METHOD:The study included 59 FCHL family members wi...

journal_title：Annals of medicine

authors： Liu ML,Ylitalo K,Vakkilainen J,Nuotio I,Valkonen M,Lahdenperä S,Viikari J,Taskinen MR

更新日期：2002-01-01 00:00:00

abstract：:The neurotoxic effects of ethanol on the human fetal brain (fetal alcohol syndrome, FAS) have been recognized for three decades, but the underlying mechanisms have remained elusive. Recently, we discovered that a single episode of ethanol intoxication lasting for several hours can trigger a massive wave of apoptotic n...

journal_title：Annals of medicine

authors： Olney JW,Wozniak DF,Farber NB,Jevtovic-Todorovic V,Bittigau P,Ikonomidou C

更新日期：2002-01-01 00:00:00

abstract：:Congenital heart disease is a significant cause of morbidity and mortality in humans, and gene mutations that underlie some of these anomalies are now being described. The NKX2.5 gene, which encodes a homeobox transcription factor, was initially discovered in mice through its similarity to the tinman gene of the fruit...

journal_title：Annals of medicine

authors： Prall OW,Elliott DA,Harvey RP

更新日期：2002-01-01 00:00:00