Prognostic value of circulating clonal plasma cells in newly diagnosed multiple myeloma.

abstract：:The mechanism of iron-induced organ failure in iron overload disorders is not known, but it is conjectured that excess iron-catalyzed free radical generation contributes to organ damage. We hypothesized that free radical generation, quantified by the presence of 20 separate cytotoxic aldehydes in plasma, would be sign...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Bartfay WJ,Lehotay DC,Sher GD,Bartfay E,Tyler B,Luo X,Liu PP

更新日期：1999-01-01 00:00:00

abstract：:To prospectively analyze factors that influence peripheral blood stem cell (PBSC) collection and hematopoietic recovery after high-dose chemotherapy (HDC), 39 patients received cyclophosphamide 4 g/m(2) and rHuG-CSF (Filgrastim) 5 &mgr;g/kg/day. Leukapheresis was started when CD34(+) cells/mL were > 5 x 10(3). A minim...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Solá C,Maroto P,Salazar R,Mesía R,Mendoza L,Brunet J,López-Pousa A,Tabernero JM,Montesinos J,Pericay C,Martínez C,Cancelas JA,López-López JJ

更新日期：1999-01-01 00:00:00

abstract：:The recent advances in the psychoneuroimmunology have suggested that the hematopoiesis may be under a neuroendocrine regulation, mainly exerted by the pineal gland. In particular, melatonin (MLT), which is the main pineal hormone, has appeared to stimulate platelet generation, probably by promoting the megakaryocyte f...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Lissoni P,Mandala M,Rossini F,Fumagalli L,Barni S

更新日期：1999-01-01 00:00:00

abstract：:Cells of the bone marrow are chiefly dedicated to two processes; the production of blood, and the production of bone that houses the hematopoietic organ. The majority of our understanding of these processes comes from data focused on one of these functions. Yet, in vivo the processes are intermixed. Our recent data de...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Taichman RS,Reilly MJ,Emerson SG

更新日期：2000-01-01 00:00:00

abstract：:Veno-occlusive disease of the liver (VOD) is an important complication in hematological transplantation. The aim of this study is to analyze the risk factors for VOD and other forms of liver toxicity in a cohort of 180 peripheral stem cell transplants performed in our Center. We find that elevated pretransplant levels...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Morado M,Ojeda E,Garcia-Bustos J,Aguado MJ,Arrieta R,Quevedo E,Navas A,Hernandez-Navarro F

更新日期：2000-01-01 00:00:00

abstract：:BackgroundAbsolute iron deficiency, irrespective of aetiology, remains a major and worldwide cause of morbidity. After correction of the causative lesion, reconstitution of haemoglobin level and body iron stores is traditionally achieved with oral administration of ferrous salts. The latter have significant gastrointe...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Jacobs P,Wood L,Bird AR

更新日期：2000-01-01 00:00:00

abstract：:Recombinant haematopoietic growth factors have been available for clinical use for over a decade, however their role in the management of patients with acute myeloid leukaemia (AML) has yet to be established. There are several potential roles for the use of growth factors in the management of patients with AML, includ...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Richardson DS,Newland AC

更新日期：2000-01-01 00:00:00

abstract：:A 43-year-old man with refractory myeloma underwent allogeneic bone marrow transplantation from his HLA-matched sibling. He was conditioned with TBI (12 Gy) followed by melphalan (140 mg/m(2) ). Immediately after conditioning was initiated, he began complaining of severe lumbago, and the level of serum calcium rose fr...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Isshiki I,Okamoto S,Mori T,Kizaki M,Takayama N,Watanabe R,Ikeda Y

更新日期：2000-01-01 00:00:00

abstract：:The clinical application of resistance reversal drugs for patients with hematologic malignancies is reviewed. The phenomenon of multidrug resistance versus other mechanisms are discussed. The pump-like mechanisms of P-glycoprotein, multidrug resistance associated protein, lung resistance protein and of other ATP bindi...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Fishman MN,Sullivan DM

更新日期：2001-01-01 00:00:00

abstract：:CD55 and CD59 are complement regulatory proteins that are linked to the cell membrane via a glycosyl-phosphatidylinositol anchor. They are reduced mainly in paroxysmal nocturnal hemoglobinuria (PNH) and in other hematological disorders. However, there are very few reports in the literature concerning their expression ...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Meletis J,Terpos E,Samarkos M,Meletis C,Apostolidou E,Komninaka V,Anargyrou K,Korovesis K,Mavrogianni D,Variami E,Viniou N,Konstantopoulos K

更新日期：2002-04-01 00:00:00

abstract：:The past decade has seen numerous lines of evidence emerging that suggest human malignancies may be sensitive to the effects of cellular immunotherapy. An increasing understanding of the nature of the effector cells and their target antigens is now leading to more focused efforts to harness these responses for therape...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Peggs KS,Mackinnon S

更新日期：2002-06-01 00:00:00

abstract：:Iron appears to exert self-regulatory control over erythroblast iron uptake, iron storage and its incorporation into haem. It does this via iron regulatory proteins (IRPs) which bind reversibly to the iron responsive elements (IREs) on the mRNA of transferrin receptor (TfR), erythroid 5-aminolaevulinic acid synthase (...

journal_title：Hematology (Amsterdam, Netherlands)

authors： McLintock LA,Fitzsimons EJ

更新日期：2002-06-01 00:00:00

abstract：:This study compares the clinical outcomes of 60 consecutive patients who received an allogeneic blood or marrow stem cell transplant (BMT) from one Human Leukocyte Antigen (HLA) mismatched related donors with those of 120 matched patients who had HLA identical sibling donors. The control patients were matched for diag...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Hasegawa W,Lipton JH,Messner HA,Jamal H,Yi QL,Daly AS,Kotchetkova N,Kiss TL

更新日期：2003-02-01 00:00:00

abstract：:We present two cases of patients with Hodgkin's lymphoma who experienced spontaneous regressions of their disease. The first case was a 31-year-old man diagnosed with stage IIIA lymphocyte predominant Hodgkin's disease in 1994, who elected to be followed without any treatment. Over the subsequent 3 years, he experienc...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Mangel J,Barth D,Berinstein NL,Imrie KR

更新日期：2003-06-01 00:00:00

abstract：:The turn of the millennium has seen clear advances in the understanding and management of Disseminated Intravascular Coagulation (DIC). The recognition that its pathogenesis stems from sustained thrombin generation in fuelling the cycle between inflammation and coagulation has seen the first successful treatment in se...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Toh CH,Dennis M

更新日期：2003-04-01 00:00:00

abstract：UNLABELLED:There is little understanding of the factors controlling the mobilization of blast cells from bone marrow to peripheral blood and tissues. The aim of this study was to evaluate the soluble hepatocyte growth factor (sHGF) and vascular endothelial growth factor (sVEGF) levels in newly diagnosed patients with a...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Aref S,Mabed M,Sakrana M,Goda T,El-Sherbiny M

更新日期：2002-10-01 00:00:00

abstract：:Thrombocytopenia is a frequent hematological complication in patients with liver cirrhosis, but its pathogenesis is not clearly understood. We evaluated the effect of iron depletion by phlebotomy on platelet count in 62 consecutive iron overloaded patients with liver cirrhosis and thrombocytopenia. After a median foll...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Franchini M

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Reactivation of hepatitis B in patients receiving chemotherapy for acute leukemia may give rise to a variety of clinical patterns including hepatitis, asymtomatic hepatic dysfunction, massive hepatic necrosis and fatal hepatic failure. Lamivudine is a nucleoside analogue which can directly suppress Hepatitis...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Yilmaz M,Dagdas S,Güler N,Aki SZ,Aköz AG,Özet G,Ayli M,Saritas U

更新日期：2003-12-01 00:00:00

abstract：:As a result of the low proliferative index, only 50% of chronic lymphocytic leukemia cases are adequate for cytogenetic analysis. Of these, about half have clonal abnormalities. The application of fluorescence in situ hybridization (FISH) to CLL has substantially enhanced our ability to detect chromosomal aberrations;...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Gozzetti A,Crupi R,Tozzuoli D

更新日期：2004-02-01 00:00:00

abstract：:Aplastic anemia (AA) is a hematological disease characterized by the deficient production of blood cells. The incidence of AA worldwide is low (1-5 new cases per 10(6) individuals per year). In contrast to other countries, no current reports exist on the incidence of this disorder in Mexico. In the present study, we h...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Benítez-Aranda H,Vélez-Ruelas MA,Díaz-Cárdenas S,Sánchez-Valle E,Xolotl-Castillo M,Dueñas-González MT,Mayani H

更新日期：2002-08-01 00:00:00

abstract：:Pharmacogenomics is a rapidly developing field of biomedical research, which investigates phenotypic and pharmacodynamic consequences of the genetic variations among individuals. The multi-drug resistance-1, MDR1 (ABCB1) gene belongs to ATP-binding cassette (ABC) family and encodes for membrane transporter P-glycoprot...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Jamroziak K,Robak T

更新日期：2004-04-01 00:00:00

abstract：:A number of pharmacological agents are currently available for the induction of the fetal hemoglobin (Hb F) to treat the patients with sickle cell disease and beta-thalassemia. In the present review, we summarized the investigation and development of these Hb F-inducing agents and introduced histone deacetylase inhibi...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Cao H

更新日期：2004-06-01 00:00:00

abstract：:The 5q- syndrome is a distinct hematological disorder with typical laboratory, morphological, cytogenetic, molecular, and prognostic features. It is defined as a myelodysplastic syndrome with a medullary blast count <5% and an isolated interstitial deletion of the long arm of chromosome 5, including bands q31-q33. The...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Giagounidis AA,Germing U,Wainscoat JS,Boultwood J,Aul C

更新日期：2004-08-01 00:00:00

abstract：:Hepcidin is a cytokine-induced antibacterial protein which is produced in the liver, circulates in the blood, and is excreted in the urine. It is a major regulator of iron balance in the intestinal mucosa, and appears to have a significant role in the pathogenesis of haemochromatosis and related disorders. Hepcidin ap...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Means RT

更新日期：2004-10-01 00:00:00

abstract：:We undertook a randomised prospective observational study to identify the true prevalence of dermatological problems on an acute in-patient haemato-oncology unit treating patients with myeloma and leukaemia (median age 52 years), that could be used to plan for optimum dermatological servicing of such a unit. As a snap...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Pearson IC,Sirohi B,Powles R,Treleaven J,Mortimer PS

更新日期：2004-10-01 00:00:00

abstract：:Cell-surface expression of CD38 in CLL has been recognised recently as a marker of progressive disease and poor outcome. In contrast to traditional staging systems, CD38 is able to identify progressive cases at an early stage. Measurement of CD38, in conjunction with other novel prognostic factors such as p53 and ZAP-...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Matrai Z

更新日期：2005-02-01 00:00:00

abstract：:Human T-lymphotropic virus type I (HTLV-I) is the causative agent in adult T-cell leukemia and HTLV-I associated myelopathy. Some other diseases such as uveitis, chronic thyroiditis, Sjögren syndrome, arthritis, acute myeloid leukemia and myelodysplastic syndrome may be also associated with HTLV-I. Several case report...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Matsushita K,Ozaki A,Arima N,Tei C

更新日期：2005-04-01 00:00:00

abstract：:Hemoglobinopathies are an important inherited disorder with a high prevalence in Southeast Asia. Hemoglobin Suan-Dok is an example of a hemoglobinopathy that was first identified and described in Thailand. It has been identified as an unstable hemoglobin variant associated with alpha-thalassemia. The role of the hemog...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Wiwanitkit V

更新日期：2005-04-01 00:00:00

abstract：:Acquired pure red cell aplasia (PRCA) is a rare condition. Traditionally it has been described in association with various etiologies such as parvovirus B19 infection, auto-immune disorders and drugs. Immunologically mediated PRCA is by far the commonest cause in adults, particularly since 1998, when a marked increase...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Lim LC

更新日期：2005-06-01 00:00:00

abstract：:Most studies looking at the reversal of drug resistance in hematological malignancies have focused on the blockade of P-glycoprotein (Pgp) pump activity, as one of the more important proteins involved in cell resistance to the chemotherapeutic agents used. In model experiments using the IM-9 lymphoblastoid cell line c...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Svirnovski A,Pasiukov V,Grigorovich S

更新日期：2005-08-01 00:00:00