Prevalence of a Single-Nucleotide Variant of SARS-CoV-2 in Korea and Its Impact on the Diagnostic Sensitivity of the Xpert Xpress SARS-CoV-2 Assay.

abstract：BACKGROUND:Iron deficiency anemia is the most common form of anemia in India. Hemoglobin A1c (HbA1c) is used in diabetic patients as an index of glycemic control reflecting glucose levels of the previous 3 months. Like blood sugar levels, HbA1c levels are also affected by the presence of variant hemoglobins, hemolytic ...

journal_title：Annals of laboratory medicine

authors： Sinha N,Mishra TK,Singh T,Gupta N

更新日期：2012-01-01 00:00:00

abstract：:In July 2010, we identified an outbreak of vancomycin-resistant enterococci (VRE) in our 26-bed neonatal intensive care unit. We performed an epidemiological investigation after clinical cultures of 2 neonates were positive for VRE. Identification, susceptibility testing, and molecular characterization were performed....

journal_title：Annals of laboratory medicine

authors： Lee WG,Ahn SH,Jung MK,Jin HY,Park IJ

更新日期：2012-01-01 00:00:00

abstract：:Sinus histiocytosis with massive lymphadenopathy, also known as Rosai-Dorfman disease is a rare disorder characterized by proliferation of distinctive histiocytes within lymph node sinuses and lymphatics, sometimes involving extranodal sites. However, clinical suspicion is difficult and there is also a lack of useful ...

journal_title：Annals of laboratory medicine

authors： Rew SY,Jang HC,Park KH,Ahn JS,Kim GE,Choi YD,Jung SI

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:To investigate the risk factors for vaginal infections and antimicrobial susceptibilities of vaginal microorganisms among women who experienced preterm birth (PTB), we compared the prevalence of vaginal microorganisms between women who experienced preterm labor (PTL) without preterm delivery and spontaneous ...

journal_title：Annals of laboratory medicine

authors： Choi SJ,Park SD,Jang IH,Uh Y,Lee A

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Commutable reference materials (RMs) are suitable for end-users for evaluating the metrological traceability of values obtained using routine measurement systems. We assessed the performance of 6 routine measurement systems with validated secondary RMs. METHODS:We tested the homogeneity, stability, and comm...

journal_title：Annals of laboratory medicine

authors： Xia C,Liu O,Wang L,Xu G

更新日期：2012-07-01 00:00:00

abstract：:Anaphylactic transfusion reactions are rare complications of blood transfusions. Anhaptoglobinemia, a condition that has high incidence in Asia, can cause allergic transfusion reactions or anaphylaxis in severe cases. A 50-yr-old Korean woman was diagnosed with relapsed acute promyelocytic leukemia. She developed thro...

journal_title：Annals of laboratory medicine

authors： Kim H,Choi J,Park KU,Kim HS,Min YH,Kim MJ,Kim HO

更新日期：2012-07-01 00:00:00

abstract：:We report a recent case in which ciprofloxacin-resistant Shigella flexneri was isolated from a 23-yr-old female patient with a history of travel to India. Prior to her admission to our internal medicine department, she experienced symptoms of high fever and generalized weakness from continuous watery diarrhea that dev...

journal_title：Annals of laboratory medicine

authors： Jeon YL,Nam YS,Lim G,Cho SY,Kim YT,Jang JH,Kim J,Park M,Lee HJ

更新日期：2012-09-01 00:00:00

abstract：:Helicobacter cinaedi is an enterohepatic species. It can cause bacteremia, gastroenteritis, and cellulitis, particularly in immunocompromised individuals, such as those with acquired immunodeficiency syndrome, malignancy, or alcoholism. There are no previous reports of H. cinaedi infection in Korea. A 71-yr-old man wa...

journal_title：Annals of laboratory medicine

authors： Kim SK,Cho EJ,Sung H,An D,Park SJ,Kim MN,Nam GB

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Genetic abnormalities in adult AML are caused most frequently by somatic mutations in exon 12 of the NPM1 gene, which is observed in approximately 35% of AML patients and up to 60% of patients with cytogenetically normal AML (CN-AML). METHODS:We performed mutational analysis, including fragment analysis and...

journal_title：Annals of laboratory medicine

authors： Jeon Y,Seo SW,Park S,Park S,Kim SY,Ra EK,Park SS,Seong MW

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Differential diagnosis between pulmonary tuberculosis (TB) and bacterial community-acquired pneumonia (CAP) is often challenging. The neutrophil-lymphocyte count ratio (NLR), a convenient marker of inflammation, has been demonstrated to be a useful biomarker for predicting bacteremia. We investigated the use...

journal_title：Annals of laboratory medicine

authors： Yoon NB,Son C,Um SJ

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:A reliable rapid assay for hepatitis C virus (HCV) may be helpful in various clinical settings. We evaluated the performance of the OraQuick HCV Rapid Antibody Test (OraSure Technologies Inc., Bethlehem, PA, USA). METHODS:Clinical sensitivity and specificity were evaluated with oral fluids and sera from 137...

journal_title：Annals of laboratory medicine

authors： Cha YJ,Park Q,Kang ES,Yoo BC,Park KU,Kim JW,Hwang YS,Kim MH

更新日期：2013-05-01 00:00:00

abstract：:Recently, lyso-globotriaosylsphingosine (lyso-Gb3) was found to be elevated in plasma of treatment naive male patients and some female patients with Fabry Disease (FD). This study tested whether lyso-Gb3 could be analyzed in dried blood spots (DBS) from filter cards and whether concentrations are elevated in newborn i...

journal_title：Annals of laboratory medicine

authors： Johnson B,Mascher H,Mascher D,Legnini E,Hung CY,Dajnoki A,Chien YH,Maródi L,Hwu WL,Bodamer OA

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the frequency of autoantibodies with mimicking specificity by using the dilution technique, to assess the usefulness of the combination of the dilution technique and red blood cell (RBC) phenotyping, and to establish a pre-transfusion testing algorithm in patients wit...

journal_title：Annals of laboratory medicine

authors： Jang MJ,Cho D,Park KU,Yazer MH,Shin MG,Shin JH,Suh SP,Ryang DW

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Documentation is very important; a considerable number of documents exist for use in accreditation inspection. However, most laboratories do not effectively manage the processes of documentation, organization, and storage. The purpose of this study was to facilitate the establishment of a strategically effec...

journal_title：Annals of laboratory medicine

authors： Hwang SH,Jung SK,Kang SJ,Cha HS,Chung SH,Lee DH

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:The dramatic increase in use of the IgG test for toxoplasma, rubella, cytomegalovirus (CMV), and herpes simplex virus (HSV) [TORCH] has led to the requirement for a high-efficiency method that can be used in the clinical laboratory. This study aimed to compare the results of BGI-Array ELISA TORCH IgG (BGI-GB...

journal_title：Annals of laboratory medicine

authors： Wu D,Wu Y,Wang L,Xu W,Zhong Q

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Vitamin D deficiency and a high mean platelet volume (MPV) are related to cardiovascular disease. We investigated whether vitamin D deficiency is associated with high MPV. METHODS:This study included 434 patients without chronic disease who were not taking vitamin D or calcium supplements. Vitamin D was mea...

journal_title：Annals of laboratory medicine

authors： Cumhur Cure M,Cure E,Yuce S,Yazici T,Karakoyun I,Efe H

更新日期：2014-03-01 00:00:00

abstract：:Reports describing significant health risks due to inadequate vitamin D status continue to generate considerable interest amongst the medical and lay communities alike. Recent research on the various molecular activities of the vitamin D system, including the nuclear vitamin D receptor and other receptors for 1,25-dih...

journal_title：Annals of laboratory medicine

authors： Morris HA

更新日期：2014-05-01 00:00:00

abstract：:Mycobacterium neoaurum is rapidly growing mycobacteria that can cause human infections. It commonly causes bloodstream infections in immunocompromised hosts, and unlike other mycobacteria species, it rarely causes pulmonary infections. We confirmed the first pulmonary infection case in Korea caused by M. neoaurum usin...

journal_title：Annals of laboratory medicine

authors： Kim CK,Choi SI,Jeon BR,Lee YW,Lee YK,Shin HB

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Multidrug-resistant (MDR) Acinetobacter spp. acquire antimicrobial agent-resistance genes via class 1 integrons. In this study, integrons were characterized to investigate the antimicrobial resistance mechanisms of MDR Acinetobacter isolates. In addition, the relationship between the integron type and integr...

journal_title：Annals of laboratory medicine

authors： Sung JY,Koo SH,Kim S,Kwon KC

更新日期：2014-07-01 00:00:00

abstract：:KBG syndrome is a very rare genetic disorder characterized by macrodontia of upper central incisors, global developmental delay, distinctive craniofacial features, short stature, and skeletal anomalies. Ankyrin repeat domain 11 gene (ANKRD11) has recently been identified as a causal factor of this syndrome. We describ...

journal_title：Annals of laboratory medicine

authors： Lim JH,Seo EJ,Kim YM,Cho HJ,Lee JO,Cheon CK,Yoo HW

更新日期：2014-09-01 00:00:00

abstract：:Mitochondria are important intracellular organelles that produce energy for cellular development, differentiation, and growth. Mitochondrial DNA (mtDNA) presents a 10- to 20-fold higher susceptibility to genetic mutations owing to the lack of introns and histone proteins. The mtDNA repair system is relatively ineffici...

journal_title：Annals of laboratory medicine

authors： Kim HR,Won SJ,Fabian C,Kang MG,Szardenings M,Shin MG

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Recently, the iNtRON VRE vanA/vanB real-time PCR (iNtRON; iNtRON Biotechnology, Korea) assay, a multiplex real-time PCR method, was introduced. In this prospective study, we compared the iNtRON assay with the Seeplex VRE ACE detection kit (Seeplex; Seegene, Korea), a conventional multiplex PCR assay. METHOD...

journal_title：Annals of laboratory medicine

authors： Huh HJ,Jang MA,Seo JY,Kim JY,Ki CS,Kim JW,Lee NY

更新日期：2015-01-01 00:00:00

abstract：:We report three patients with normal karyotype (NK) ALL, who showed genetic aberrations as determined by high-resolution single nucleotide polymorphism array (SNP-A) analysis at both diagnosis and relapse. We evaluated the clinical relevance of the SNP-A assay for the detection of subtle changes in the size of affecte...

journal_title：Annals of laboratory medicine

authors： Park SH,Lee SH,Kim SY,Lee SM,Yi J,Kim IS,Kim HH,Chang CL,Lee EY

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Diffuse interstitial lung diseases (DILDs) form a part of a heterogeneous group of respiratory diseases. Bronchoalveolar lavage (BAL) analysis has been used for differential diagnosis of DILDs, but their clinical usefulness is controversial. The aim of this study was to investigate the clinical usefulness of...

journal_title：Annals of laboratory medicine

authors： Lee W,Chung WS,Hong KS,Huh J

更新日期：2015-03-01 00:00:00

abstract：:The genetic variant rs16754 of Wilms tumor gene 1 (WT1) has recently been described as an independent prognostic factor in AML patients. It is of great interest to test whether WT1 single nucleotide polymorphism can be used as a molecular marker in other types of cancer, to improve risk and treatment stratification. W...

journal_title：Annals of laboratory medicine

authors： Kim N,Kim IS,Chang CL,Kang JE,Lee EY,Shin HJ

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:FcRγ-deficient natural killer (NK) cells (g(-)NK cells) have been associated with cytomegalovirus (CMV) infection. However, the frequency of g(-)NK cells in a CMV-endemic area (i.e., Korea) has not yet been studied. We examined the frequency of g(-)NK cells and expression of CD57 on NK cells in cord blood (C...

journal_title：Annals of laboratory medicine

authors： Baek HJ,Kim DW,Phan MT,Kim JS,Yang JH,Choi JI,Lee JJ,Shin MG,Ryang DW,Kim SK,Lee SH,Kook H,Cho D

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Resistance of Mycobacterium tuberculosis to anti-tuberculosis (TB) drugs is almost exclusively due to spontaneous chromosomal mutations in target genes. Rapid detection of drug resistance to both first- and second-line anti-TB drugs has become a key component of TB control programs. Technologies that allow r...

journal_title：Annals of laboratory medicine

authors： Lee SH,Choi HB,Yu SY,Chang UJ,Kim CK,Kim HJ

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Soluble suppression of tumorigenicity 2 (sST2) has emerged as a novel biomarker for heart failure, and serum sST2 concentrations could be increased in inflammatory diseases. We explored whether sST2 is related to cardiac dysfunction/failure and has a prognostic role in patients with suspected sepsis. METHOD...

journal_title：Annals of laboratory medicine

authors： Hur M,Kim H,Kim HJ,Yang HS,Magrini L,Marino R,Cardelli P,Di Somma S,GREAT Network.

更新日期：2015-11-01 00:00:00

abstract：:Cornelia de Lange syndrome (CdLS) is a clinically and genetically heterogeneous congenital anomaly. Mutations in the NIPBL gene account for a half of the affected individuals. We describe a family with CdLS carrying a novel pathogenic variant of the SMC1A gene identified by exome sequencing. The proband was a 3-yr-old...

journal_title：Annals of laboratory medicine

authors： Jang MA,Lee CW,Kim JK,Ki CS

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Carbapenem-resistant Pseudomonas aeruginosa (CRPA) and Acinetobacter baumannii (CRAB) are the leading causes of nosocomial infections. A rapid and sensitive test to detect CRPA and CRAB is required for appropriate antibiotic treatment. We optimized a loop-mediated isothermal amplification (LAMP) assay to det...

journal_title：Annals of laboratory medicine

authors： Kim HJ,Kim HS,Lee JM,Yoon SS,Yong D

更新日期：2016-01-01 00:00:00