Role of tight junction-associated MARVEL protein marvelD3 in migration and epithelial-mesenchymal transition of hepatocellular carcinoma.

abstract：:Desmosomes are cell adhesion structures (junctions) that are particularly abundant in cells derived from the ectodermal lineages. These junctions are required to maintain the integrity of organs subjected to mechanical stress, in particular the skin and the heart. This conclusion is partially based on tissue fragility...

journal_title：Cell adhesion & migration

authors： Schmidt A,Koch PJ

更新日期：2007-01-01 00:00:00

abstract：:Cell colonization is an important in a wide variety of biological processes and applications including vascularization, wound healing, tissue engineering, stem cell differentiation and biosensors. During colonization porous 3D structures are used to support and guide the ingrowth of cells into the matrix. In this revi...

journal_title：Cell adhesion & migration

authors： Lawrence BJ,Madihally SV

更新日期：2008-01-01 00:00:00

abstract：:Exosomes are small vesicles of endosomal origin that can be released by many different cells to the microenvironment. Exosomes have been shown to participate in the immune system, by mediating antigen presentation. We have recently shown the presence of both mRNA and microRNA in exosomes, specifically in exosomes deri...

journal_title：Cell adhesion & migration

authors： Lotvall J,Valadi H

更新日期：2007-07-01 00:00:00

abstract：:Loss of cortical neurons may lead to sever and sometimes irreversible deficits in motor function in a number of neuropathological conditions. Absence of spontaneous axonal regeneration following trauma in the adult central nervous system (CNS) is attributed to inhibitory factors associated to the CNS white matter and ...

journal_title：Cell adhesion & migration

authors： Gaillard A,Jaber M

更新日期：2007-10-01 00:00:00

abstract：:ArgBP2, a member of the SoHo family of adapter proteins, is a regulator of actin-dependent processes such as cell adhesion and migration. Recent data from our lab revealed that by regulating adhesion and migration of pancreatic cancer cells, ArgBP2 is endowed with an anti-tumoral function. We could show that part of t...

journal_title：Cell adhesion & migration

authors： Roignot J,Soubeyran P

更新日期：2009-04-01 00:00:00

abstract：:Emerging evidence has indicated a regulatory role of cyclin-dependent kinase 5 (Cdk5) in synaptic plasticity as well as in higher brain functions, such as learning and memory. However, the molecular and cellular mechanisms underlying the actions of Cdk5 at synapses remain unclear. Recent findings demonstrate that Cdk5...

journal_title：Cell adhesion & migration

authors： Fu AK,Ip NY

更新日期：2007-04-01 00:00:00

abstract：:The pushing structures of cells include laminar sheets, termed lamellipodia, made up of a meshwork of actin filaments that grow at the front and depolymerise at the rear, in a treadmilling mode.We here develop a mathematical model to describe the turnover and the mechanical properties of this network.Our basic modelin...

journal_title：Cell adhesion & migration

authors： Oelz D,Schmeiser C,Small JV

更新日期：2008-04-01 00:00:00

abstract：:Cell motility is a highly coordinated multistep process. Uncovering the mechanism of myosin II (MYO2) activation responsible for the contractility underlying cell protrusion and retraction provides clues on how these complementary activities are coordinated. Several protein kinases have been shown to activate MYO2 by ...

journal_title：Cell adhesion & migration

authors： Tan I,Leung T

更新日期：2009-07-01 00:00:00

abstract：:Cell cytoskeleton proteins are fundamental to cell shape, cell adhesion and cell motility, and therefore play an important role during angiogenesis. One of the major regulators of cytoskeletal protein expression is serum response factor (SRF), a MADS-box transcription factor that regulates multiple genes implicated in...

journal_title：Cell adhesion & migration

authors： Franco CA,Li Z

更新日期：2009-07-01 00:00:00

abstract：:Angiogenesis, or the formation of new blood vessels from preexisting ones, is essential to establish the vascular circuit during embryonic development. During angiogenic sprouting, endothelial cells exhibit a diverse array of cellular behaviors. Endothelial tip cells must migrate extensively and proliferate in respons...

journal_title：Cell adhesion & migration

authors： Siekmann AF,Lawson ND

更新日期：2007-04-01 00:00:00

abstract：:Antipsychotic drugs are divided into two groups: typical and atypical. Recent clinical studies show atypical antipsychotics have advantages over typical antipsychotics in a wide variety of neuropsychiatric conditions, in terms of greater efficacy for positive and negative symptoms, beneficial effects on cognitive func...

journal_title：Cell adhesion & migration

authors： He J,Kong J,Tan QR,Li XM

更新日期：2009-01-01 00:00:00

abstract：:Hemidesmosomes (HD) are adhesive protein complexes that mediate stable attachment of basal epithelial cells to the underlying basement membrane. The organization of HDs relies on a complex network of protein-protein interactions, in which integrin alpha6beta4 and plectin play an essential role. Here we summarize the c...

journal_title：Cell adhesion & migration

authors： de Pereda JM,Ortega E,Alonso-García N,Gómez-Hernández M,Sonnenberg A

更新日期：2009-10-01 00:00:00

abstract：:EGFR, a critical regulator of oncogenic signaling during cancer progression, is capable of integrating multireceptor signaling pathways that promote metastasis. EGFR is subject to regulatory cues from the extracellular matrix (ECM), of which hyaluronan (HA) is a major component. In mammary tumors, HA is deposited in t...

journal_title：Cell adhesion & migration

authors： Louderbough JM,Lopez JI,Schroeder JA

更新日期：2010-01-01 00:00:00

abstract：:The poor prognosis of most non small cell lung carcinomas is due to their ability to efficiently invade surrounding tissues and blood vessels, finally metastasizing to distant organs. Integrin mediated adhesive interaction with the surrounding extracellular matrix is a key limiting step in the regulation of the invasi...

journal_title：Cell adhesion & migration

authors： Caccavari F,Valdembri D,Sandri C,Bussolino F,Serini G

更新日期：2010-01-01 00:00:00

abstract：:Lissencephaly is a devastating neurological disorder caused by to defective neuronal migration. LIS1 (or PAFAH1B1), the gene mutated in lissencephaly patients and its binding protein NDEL1 were found to regulate cytoplasmic dynein function and localization. LIS1 and NDEL1 also play a pivotal role on a microtubule regu...

journal_title：Cell adhesion & migration

authors： Yamada M,Hirotsune S,Wynshaw-Boris A

更新日期：2010-04-01 00:00:00

abstract：:Sirt1 is a type III histone deacetylase implicated in a wide range of physiological and pathophysiological roles. Acting though a myriad of non-histone substrates, Sirt1 modulates transcriptional regulation of energy metabolism and stress response, with important consequences on cell survival and a myriad of human pat...

journal_title：Cell adhesion & migration

authors： Tang BL

更新日期：2010-04-01 00:00:00

abstract：:Ovarian cancer is the most lethal gynecologic cancer, and this is largely related to its late diagnosis. High grade serous cancers often initially respond to chemotherapy, resulting in a better survival rate, compared to other ovarian carcinoma subtypes. We review recent work identifying a survival-associated gene exp...

journal_title：Cell adhesion & migration

authors： Spivey KA,Banyard J

更新日期：2010-04-01 00:00:00

abstract：:Cell surface membranes are generally considered as inert and hydrophobic providing a stable physical barrier that anchor proteins and maintain cellular homeostasis between the intra- and the extra-cellular environment. The integral proteins that transverse membranes do so once or multiple times and can function alone ...

journal_title：Cell adhesion & migration

authors： Manolios N,Ali M,Bender V

更新日期：2010-04-01 00:00:00

abstract：:Cells sense the rigidity of their environment and respond to it. Most studies have been focused on the role of adhesion complexes in rigidity sensing. In particular, it has been clearly shown that proteins of the adhesion complexes were stretch-sensitive, and could thus trigger mechano-chemical signaling in response t...

journal_title：Cell adhesion & migration

authors： Fouchard J,Mitrossilis D,Asnacios A

更新日期：2011-01-01 00:00:00

abstract：:During vertebrate brain development, migration of neurons from the germinal zones to their final laminar positions is essential to establish functional neural circuits. Whereas key insights into neuronal migration initially came from landmark studies identifying the genes mutated in human cortical malformations, cell ...

journal_title：Cell adhesion & migration

authors： Trivedi N,Solecki DJ

更新日期：2011-01-01 00:00:00

abstract：:Cell adhesion molecules (CAMs) are now known to mediate much more than adhesion between cells and between cells and the extracellular matrix. Work by many researchers has illuminated their roles in modulating activation of molecules such as receptor tyrosine kinases, with subsequent effects on cell survival, migration...

journal_title：Cell adhesion & migration

authors： Gibson NJ

更新日期：2011-01-01 00:00:00

abstract：:Embryonic stem (ES) cells have a broad potential application in regenerative medicine and can be differentiated into cells of all three germ layers. Adhesion of ES cells to extracellular matrix (ECM) proteins is essential for the differentiation pathway; Cell-ECM adhesion is mediated by integrins that have the ability...

journal_title：Cell adhesion & migration

authors： Pimton P,Sarkar S,Sheth N,Perets A,Marcinkiewicz C,Lazarovici P,Lelkes PI

更新日期：2011-01-01 00:00:00

abstract：:The neural crest is an evolutionary adaptation, with roots in the formation of mesoderm. Modification of neural crest behavior has been is critical for the evolutionary diversification of the vertebrates and defects in neural crest underlie a range of human birth defects. There has been a tremendous increase in our kn...

journal_title：Cell adhesion & migration

authors： Klymkowsky MW,Rossi CC,Artinger KB

更新日期：2010-10-01 00:00:00

abstract：:Neuroblasts generated in the adult subventricular zone (SVZ) migrate through the rostral migratory stream (RMS) to the olfactory bulb (OB). Previous work uncovered motility ranging from straight to complex, but it was unclear if directional changes were stochastic or exhibited stereotypical patterns. Here, we provide ...

journal_title：Cell adhesion & migration

authors： Martinez-Molina N,Kim Y,Hockberger P,Szele FG

更新日期：2011-01-01 00:00:00

abstract：:The cadherin family is classified into classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Genomic structures distinguish between PCDHs and other cadherins, and between clustered and non-clustered PCDHs. The phylogenetic analysis with full sequences of non-clustered PCDHs enabled them to be further c...

journal_title：Cell adhesion & migration

authors： Kim SY,Yasuda S,Tanaka H,Yamagata K,Kim H

更新日期：2011-03-01 00:00:00

abstract：:Cell adhesion is an important part of many complex biological processes. It plays crucial roles in cancer, development, and maintenance of stem cell compartment. The measurement of adhesion under experimental conditions might provide important information for cell biology. There are several protocols to measure adhesi...

journal_title：Cell adhesion & migration

authors： Zepeda-Moreno A,Taubert I,Hellwig I,Hoang V,Pietsch L,Lakshmanan VK,Wagner W,Ho AD

更新日期：2011-05-01 00:00:00

abstract：:Neuropilin-2 (NRP2) is a receptor expressed by tumor cells and endothelial cells (EC) that binds both semaphorin 3F (SEMA3F), a potent inhibitor of tumor angiogenesis and metastasis, and vascular endothelial growth factor (VEGF), a potent stimulator of tumor angiogenesis. It was found that glioblastoma and melanoma ce...

journal_title：Cell adhesion & migration

authors： Coma S,Shimizu A,Klagsbrun M

更新日期：2011-05-01 00:00:00

abstract：:Cell adhesion to extracellular matrix proteins or to other cells is essential for the control of embryonic development, tissue integrity, immune function and wound healing.  Adhesions are tightly spatially regulated structures containing over a hundred different proteins that co-ordinate both dynamics and signalling e...

journal_title：Cell adhesion & migration

authors： Morton PE,Parsons M

更新日期：2011-07-01 00:00:00

abstract：:We present a picture of filopodial growth and retraction from physics perspective, where we emphasize the significance of the role played by protein fluxes due to spatially extended nature of the filopodium. We review a series of works, which used stochastic simulations and mean field analytical modeling to find the c...

journal_title：Cell adhesion & migration

authors： Zhuravlev PI,Papoian GA

更新日期：2011-09-01 00:00:00

abstract：:Cell migration is critical for proper development of the embryo and is also used by many cell types to perform their physiological function. For instance, cell migration is essential for immune cells to monitor the body and for epithelial cells to heal a wound whereas, in cancer cells, acquisition of migratory capabil...

journal_title：Cell adhesion & migration

authors： Theveneau E,Mayor R

更新日期：2011-11-01 00:00:00