Slowed information processing in HIV-1 disease. The Multicenter AIDS Cohort Study (MACS).

Abstract:

:This investigation examined the effects of HIV-1 infection on speeded complex cognitive processing in a group of HIV-negative (n = 666), HIV-positive symptomatic (n = 156), and HIV-positive asymptomatic (n = 623) participants while controlling for the effects of slowed motor functioning, peripheral neuropathy, and several other putative confounds. Stroop Interference and reaction-time tasks served as anchor procedures to assess cognitive processing. The present findings suggest that HIV-1 infection is capable of compromising CNS-mediated cognitive processes (speeded processing) infringing upon their efficacy in the symptomatic stages of the disease while sparing individuals in the asymptomatic stage. The detrimental effects observed on information-processing mechanisms associated with HIV infection persisted despite the use of procedures to control for peripheral nerve integrity and other potential confounds.

authors

Llorente AM,Miller EN,D'Elia LF,Selnes OA,Wesch J,Becker JT,Satz P

doi

10.1076/jcen.20.1.60.1489

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

60-72

issue

1

eissn

1380-3395

issn

1744-411X

journal_volume

20

pub_type

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