Abstract:
:A current model proposes that memory consists of two functionally separate systems that have different neurological substrates. Declarative memory appears to be dependent on the diencephalic medial temporal lobe system whereas some speculate that the basal ganglia may be a neurological substrate for procedural memory. This study tested the role of the basal ganglia in regulating different types of procedural skills by comparing performance on a motor and a visuoperceptual skill learning task. Twenty Parkinson's (PD) patients and 20 normal control subjects performed two procedural learning tasks (rotary pursuit and mirror reading) and one declarative learning task (paired associates) over 3 days. The results showed that PD patients were not impaired on mirror reading or paired associate learning. On rotary pursuit, performance levels on day 1 were similar between groups, but the PD group showed less improvement across days than controls. However, only patients with more advanced symptoms of PD showed impaired rotary pursuit learning, and this could not be attributed directly to deficits in primary motor or general cognitive function. These findings suggest that the underlying processes/procedures for procedural learning are specific to the task, and are supported by different neuroanatomical systems.
journal_name
J Clin Exp Neuropsycholjournal_title
Journal of clinical and experimental neuropsychologyauthors
Harrington DL,Haaland KY,Yeo RA,Marder Edoi
10.1080/01688639008400978subject
Has Abstractpub_date
1990-03-01 00:00:00pages
323-39issue
2eissn
1380-3395issn
1744-411Xjournal_volume
12pub_type
杂志文章abstract::Lateralization of speech dominance was established using amobarbital for 22 patients with vascular malformations lateralized to the left cerebral hemisphere. Patients' histories were negative for clinically evident neurological events (e.g., seizures or hemorrhage) prior to adulthood. The vascular lesions were categor...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688639408402690
更新日期:1994-10-01 00:00:00
abstract::It has been hypothesized that children who are at genetic risk to develop bipolar disorder demonstrate deficiencies consistent with the syndrome of nonverbal learning disabilities (NLD); however, this hypothesis has never been tested directly. In the present study, a group of at-risk children (AR group; N = 28) was co...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1076/jcen.24.3.280.980
更新日期:2002-05-01 00:00:00
abstract:INTRODUCTION:The prevalence of cognitive, sensory, and physical impairments is expected to grow alongside increasing life expectancy. These chronic conditions pose challenges for geriatric assessment. We examined whether Brief Cognitive Assessment Tool (BCAT) modifications to accommodate visual and motor limitations wo...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2017.1423041
更新日期:2018-09-01 00:00:00
abstract::To determine the specificity of suggested endophenotypes of pediatric bipolar disorder (PBD), the performance of 15 euthymic children with PBD was contrasted with that of 20 children with attention-deficit/hyperactivity disorder (ADHD), a population with reportedly similar executive dysfunction, and 18 children with b...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2010.493146
更新日期:2011-01-01 00:00:00
abstract::While most would agree that mild traumatic brain injury (TBI) is associated with early neuropsychological problems, disagreement exists regarding their persistence and whether they are the cause of the disabilities experienced by some people. The aim of this study was to examine how the criteria used to define mild TB...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1076/jcen.23.6.729.1019
更新日期:2001-12-01 00:00:00
abstract::The case of a patient with profound retrograde and minor anterograde amnesia is described and used to discuss the kind of brain damage which will most likely result in persistent retrograde amnesia as the principal symptom. The patient was an industrial manager who had fallen off a horse four years prior to the presen...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688639308402610
更新日期:1993-11-01 00:00:00
abstract::The aim was to study whether an inkblot technique can reveal differential deficits of ideation and memory related to the side and site of brain damage. Seventy-three patients with focal brain lesions and nine control patients were studied with a modified Holtzman Inkblot Technique. The results confirmed the previous R...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688638708405211
更新日期:1987-12-01 00:00:00
abstract::This study compared children with ADHD (n = 19), reading disorder (RD; n = 17), ADHD+RD (n = 21), and control children (n = 19) on linguistic and executive function measures. We found no evidence of response inhibition problems in ADHD or RD when a baseline measure of functioning was taken into account. General workin...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390903066865
更新日期:2010-04-01 00:00:00
abstract::The relationships between hemispheric function and components of the imagery process were examined in patients with unilateral right and left brain damage and in intact adult subjects. In the image generation condition, subjects were required to mentally generate Katakana letters corresponding to Hiragana letters disp...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688639408402669
更新日期:1994-08-01 00:00:00
abstract::Ten men (ages 18-39) with clear histories of Infantile autism and approximately average verbal and nonverbal intelligence were studied with a comprehensive battery of neuropsychological tests. Comparisons with 10 matched normal controls showed no significant differences in many visuoperceptual or memory skills or in s...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688638808408236
更新日期:1988-03-01 00:00:00
abstract:AIM:This study tested the mediating role of probabilistic reasoning ability in the relationship between fluid intelligence and advantageous decision making among adolescents in explicit situations of risk--that is, in contexts in which information on the choice options (gains, losses, and probabilities) were explicitly...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2014.918091
更新日期:2014-01-01 00:00:00
abstract::Persons who have the genetic mutation responsible for Huntington's disease (HD) have been shown to exhibit lower cognitive test scores years prior to manifest HD. Most studies have examined cognitive performance in presymptomatic persons by using estimated times to manifest HD based on published algorithms. We followe...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2011.574606
更新日期:2011-10-01 00:00:00
abstract::The present study sought a clearer understanding of spatial memory function consequent to temporal lobe resection, and, in particular, of spatial memory function with respect to two- as well as three-dimensional frames of reference. Relative to a group of 15 control participants, a group of 15 epilepsy patients with r...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390500434359
更新日期:2006-11-01 00:00:00
abstract::The standardization sample from the WMS-III (weighted N = 1250) (The Psychological Corporation, 1997; Tulsky & Ledbetter, 2000), which varied in age from 16 to 89, was used to determine whether storage of verbal and spatial information was affected by normal aging. A previous study with the same sample using an analys...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390490496678
更新日期:2004-06-01 00:00:00
abstract::Obstructive sleep apnea syndrome is a sleep disorder that may affect many brain functions. We are interested in the cognitive consequences of the condition with regard to the quality of life of individuals with this disorder. A debate is still underway as to whether cognitive difficulties caused by obstructive sleep a...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章,评审
doi:10.1080/13803395.2016.1253668
更新日期:2017-09-01 00:00:00
abstract::The goal of the current study was to evaluate presetting, response inhibition, set shifting, and a priori planning in autism: abilities that can be lumped together under the term cognitive flexibility. Cognitive flexibility is an aspect of executive functioning, which in turn is mediated by the prefrontal cortical lob...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390601186668
更新日期:2008-01-01 00:00:00
abstract::P-type dyslexic, L-type dyslexic, and normal reading boys, and their parents were administered a number of cognitive tasks. The P- and L-type dyslexic boys showed impaired performances on tasks representing a verbal/memory dimension. In addition, L-type dyslexics performed worse on a figure-rotation task, a result tha...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688639008401026
更新日期:1990-12-01 00:00:00
abstract::Huntington disease (HD) is a neurodegenerative disease associated with cognitive, motor, and psychiatric deterioration over time. Although there is currently no cure for HD, there has been a surge of clinical trials available to patients with HD over the past 5 years. However, cognitive measures have generally been la...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390903313564
更新日期:2010-07-01 00:00:00
abstract:INTRODUCTION:Headache is one of the most commonly reported and longest lasting symptoms that concussed athletes report, yet the etiology of headache symptoms following concussion is not entirely clear. The purpose of this study was to determine whether the e4 allele of the apolipoprotein E (APOE) gene influences the pr...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2016.1177491
更新日期:2016-11-01 00:00:00
abstract:INTRODUCTION:Financial management skills-that is, the skills needed to handle personal finances such as banking and paying bills-are essential to a person's autonomy, independence, and community living. To date, no comprehensive review of financial management skills instruments exists, making it difficult for clinician...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章,评审
doi:10.1080/13803395.2015.1087468
更新日期:2016-01-01 00:00:00
abstract::Determining the order of events is essential for accurate memory recollection: an ability previously linked to both frontal and medial temporal functioning. Frontal-subcortical and medial temporal dysfunction typify vascular dementia (VaD) and Alzheimer's disease (AD), respectively. Therefore, we assessed patients' or...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390903418918
更新日期:2010-07-01 00:00:00
abstract::Both amnestic and nonamnestic deficits have been observed in patients with mild cognitive impairment (MCI). Most studies have focused on impairment on single cognitive tests rather than amalgamation of the results of several measures to arrive at a composite impairment index. In this investigation, we examined 20 MCI ...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390600681206
更新日期:2007-04-01 00:00:00
abstract::There is an increasing need for standardized assessment of cognition in older patients that is relatively brief, easy to administer, and has normative data adjusted for age and educational attainment. We tested 332 literate, cognitively normal, Spanish persons older than 49 years from the Memory Clinic of Fundació ACE...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2011.630652
更新日期:2012-01-01 00:00:00
abstract::Although there is considerable anecdotal and empirical evidence showing that retrospective memory may be adversely affected during pregnancy and postpartum, it remains unclear whether capacity for prospective memory is also impaired. In Phase 1 of the present study 20 participants in their third trimester of pregnancy...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390701874379
更新日期:2008-11-01 00:00:00
abstract::Monocular occlusion has been posited to reduce activation of the contralateral hemisphere ("Sprague effect"), thus inducing a contralateral spatial bias (toward the viewing eye). Healthy right-handed participants bisected horizontal lines during monocular eye viewing. Although subjects tended to deviate away from the ...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2013.770824
更新日期:2013-01-01 00:00:00
abstract::Neurocognitive function is reduced in major depression, but uncertainties remain about if and to what extent improvement in neurocognitive function follows remission of depressive symptoms. A total of 30 patients with Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV) diagnosis of unipolar m...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390601147686
更新日期:2007-11-01 00:00:00
abstract:INTRODUCTION:Reactive oxygen species are involved in the functional changes necessary for synaptic plasticity, memory, and cognitive function. It is far from clear whether the increased excitability, and which forms of neuronal excitability, should be considered a part of the learning process or, rather, cellular manif...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2015.1007118
更新日期:2015-01-01 00:00:00
abstract::Although recognized as one of the most common hereditary diseases of the nervous system, the neuropsychological deficits in Friedreich's ataxia (FA) have rarely been studied. A protocol was constructed to assess the major cognitive areas in patients with FA and pair-matched normal controls. Motor difficulties, dysarth...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1076/jcen.24.5.677.1014
更新日期:2002-08-01 00:00:00
abstract:INTRODUCTION:Language dysfunction has recently been suggested to be one route to alexithymia, an impairment in recognizing and communicating one's own emotions. Neuropsychological evidence is needed to investigate the possibility that acquired language problems could underlie acquired alexithymia. METHOD:This project ...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2020.1770703
更新日期:2020-07-01 00:00:00
abstract::This study determined whether the Vocabulary-Digit Span difference score and discriminant function based on subtests of the Wechsler Adult Intelligence Scale-Revised (WAIS-R) developed by Mittenberg et al. (1995) could differentiate patients with moderate and severe traumatic brain injuries (n = 50) from persons with ...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1076/jcen.20.2.167.1171
更新日期:1998-04-01 00:00:00