Worker sensitivity and reactivity: indicators of worker susceptibility to nasal irritation.

Abstract:

:This study examines the determinants of susceptibility to the irritant effects of sodium borate in 18 responsive workers identified through repeated self-reports of nasal irritation. For each worker, susceptibility was characterized by two features; reactivity and sensitivity, as estimated from the slope and intercept parameters from their individual exposure-response regression model. Individual estimates of reactivity and sensitivity were then examined to evaluate the importance of personal and environmental characteristics in determining susceptibility. The use of nasal sprays, current smoking and allergies were associated with lower reactivity, while high exposures to borate dust were associated with higher sensitivity. To examine possible biologic mechanisms for the irritant response, a toxicokinetic dose model was used to calculate nasal osmolarity during symptom intervals. The estimated levels suggest that osmolar activation of mast cells to release histamine and other mediators is a plausible mechanism by which these workers may experience nasal irritation.

journal_name

Am J Ind Med

authors

Woskie SR,Eisen EE,Wegman DH,Hu X,Kriebel D

doi

10.1002/(sici)1097-0274(199812)34:6<614::aid-ajim1

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

614-22

issue

6

eissn

0271-3586

issn

1097-0274

pii

10.1002/(SICI)1097-0274(199812)34:6<614::AID-AJIM1

journal_volume

34

pub_type

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