Abstract:
:This study examines the determinants of susceptibility to the irritant effects of sodium borate in 18 responsive workers identified through repeated self-reports of nasal irritation. For each worker, susceptibility was characterized by two features; reactivity and sensitivity, as estimated from the slope and intercept parameters from their individual exposure-response regression model. Individual estimates of reactivity and sensitivity were then examined to evaluate the importance of personal and environmental characteristics in determining susceptibility. The use of nasal sprays, current smoking and allergies were associated with lower reactivity, while high exposures to borate dust were associated with higher sensitivity. To examine possible biologic mechanisms for the irritant response, a toxicokinetic dose model was used to calculate nasal osmolarity during symptom intervals. The estimated levels suggest that osmolar activation of mast cells to release histamine and other mediators is a plausible mechanism by which these workers may experience nasal irritation.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Woskie SR,Eisen EE,Wegman DH,Hu X,Kriebel Ddoi
10.1002/(sici)1097-0274(199812)34:6<614::aid-ajim1subject
Has Abstractpub_date
1998-12-01 00:00:00pages
614-22issue
6eissn
0271-3586issn
1097-0274pii
10.1002/(SICI)1097-0274(199812)34:6<614::AID-AJIM1journal_volume
34pub_type
杂志文章abstract::This report describes the reanalysis of a cross-sectional study of asthma in a large cohort of autoworkers with exposure to metalworking fluids (MWF). There is strong evidence from case reports, clinical studies, and medical surveillance data that exposure to MWF can cause asthma, yet no association was found in the o...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199706)31:6<671::aid-ajim1
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:Media work is characterized by information flow, deadlines, and 24/7 alertness. Good recovery prevents stress-related disorders. METHODS:The standardized questionnaire included items about health, health habits, sleep, work conditions, and work stress. Recordings of 24-hr heart rate variability (HRV) and fo...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22042
更新日期:2012-07-01 00:00:00
abstract::Nanoparticles are being used in ever increasing numbers in a range of industrial and medical products. Questions surrounding their potential to cause toxic effects in humans have been raised. Although animal experiments predict that nanoparticles are more toxic than their larger counterparts there are few descriptions...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20855
更新日期:2010-08-01 00:00:00
abstract::Investigators must often rely on self-reported work history information collected with questionnaires. However, little is known about the agreement between self-reported estimates of exposure and records kept by companies. As part of a cross-sectional medical study of structural fumigation workers, self-reported work ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199710)32:4<364::aid-ajim7
更新日期:1997-10-01 00:00:00
abstract::In 1982, White et al published an assessment of quantitative leukemia risk associated with lifetime occupational exposure to benzene. At about the same time, IARC (1982) published estimates of quantitative cancer risk associated with industrial chemicals. Benzene was one of the two chemicals selected by IARC for its r...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/ajim.4700070507
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:The purpose of Pre-Adult Latency Study was to evaluate lung findings among adults who had been environmentally exposed to Libby Amphibole only during childhood and adolescence. METHODS:Recruitment was restricted to volunteers who attended primary and/or secondary school, lived in Libby, MT, prior to age 23 ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22674
更新日期:2017-01-01 00:00:00
abstract::Pesticides may be transformed by chemical and biological processes or transported from the site of application by several processes including runoff, movement through the soil to ground water, volatilization, transport on soil particles, and wind erosion. Contamination of water by pesticide residues is a matter of con...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700180418
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:A medical surveillance program of benzene-exposed workers has to be established in such a way as to observe early signs of benzene-induced cytopenia, pancytopenia, or leukemia. This study evaluates the utility of routine medical survey applied to benzene-exposed workers by analyzing the hematological, immuno...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10296
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Self-reported exposure to secondhand smoke (SHS) has been associated with elevated inflammatory markers in adults. The association between SHS indicated by serum cotinine and markers of inflammation has not been investigated in adult workers. METHODS:Using the subpopulation of employed participants (20 year...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20591
更新日期:2008-08-01 00:00:00
abstract::Injury is the leading cause of death in adolescence, with the highest rates for 15- to 19-year-olds, an age span also marked, for many, by entry into the workforce. Occupational injuries affecting youth occur in the context of the larger problem of injury affecting children and adolescents. An understanding of the bro...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700240307
更新日期:1993-09-01 00:00:00
abstract::A Health Hazard Evaluation was conducted by the National Institute for Occupational Safety and Health in an area of a large chemical plant that manufactured the stilbene derivative 4,4'-diaminostilbene-2,2'-disulfonic acid, an intermediate used for the production of optical brightening agents. Men employed in the area...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700180107
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:The need to expand the use of evaluation to learn how education programs contribute to workers' occupational safety and health is well documented. Similarly recognized is the need to expand workers' involvement as primary stakeholders in program evaluation. METHODS:Articles for this review were identified t...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/1097-0274(200011)38:5<584::aid-ajim11>3.0.
更新日期:2000-11-01 00:00:00
abstract::Both subcutaneous and hepatic hemangiosarcomas were induced in mice exposed to vinyl chloride monomer, and for the first time, the ultrastructure of hemangiosarcomas related to vinyl chloride exposure has been described. The subcutaneous hemangiosarcoma developed in a mouse's ear 29 weeks after exposure to 10 ppm viny...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700020205
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVES:To examine disparities between job control scores in Black and White subjects and attempt to discern whether self-rated low job control in Blacks may arise from structural segregation into different jobs, or represents individual responses to race-based discrimination in hiring or promotion. METHODS:Data fr...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22255
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Experimental and clinical evidence suggest that stress can lead to ill-health through the disregulation of the hypothalamic-pituitary-adrenal (HPA) axis. Studies to date have produced equivocal results likely due to different methodologies and failure to account for confounding factors. This investigation ai...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20659
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Farmers have been previously reported to have higher rates of depression and suicide compared to other occupations. Comparisons of depressive symptoms and risk factors for states should increase understanding of depression in farmers. METHODS:Representative samples of 385 Iowa and 470 Colorado male principa...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(200004)37:4<382::aid-ajim8
更新日期:2000-04-01 00:00:00
abstract::A microcomputer system for on-lone analysis of saccadic and smooth-pursuit tracking eye movements is described. Results from a longitudinal study of lead workers and matched controls reveal a consistent decrease in saccade accuracy in the lead workers compared to the controls. Saccade peak velocity and latency and smo...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700010112
更新日期:1980-01-01 00:00:00
abstract::In a Swedish cohort of workers (n = 6,454) from seven aluminum foundries and three secondary aluminum (scrap) smelters there was no overall excess risk of cancer among male or female workers less than 85 years of age (males: 325 observed cases, standardized incidence ratio (SIR) 1.02, 95% confidence interval (CI) 0.91...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,多中心研究
doi:10.1002/(sici)1097-0274(199711)32:5<467::aid-ajim6
更新日期:1997-11-01 00:00:00
abstract::The aim of the investigation was to study whether laboratory work or other types of chemical work at one petrochemical plant were associated with an increased risk for miscarriage or reduced birthweight. The study was based on questionnaire data for 95% of the women working at the plant between 1973 and 1987. A statis...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700160507
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Harvesting of blueberries is associated with musculoskeletal injury. This study assessed the effects of several alternative designs of the harvesting rake. METHODS:A community-based work team selected rake design for intervention and pilot tested potential design modifications to the blueberry harvesting ra...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20554
更新日期:2008-04-01 00:00:00
abstract::This paper reviews the epidemiologic evidence of cancer risks among workers in aluminum reduction plants with emphasis on associations with specific work areas and exposures. Studies of workers manufacturing carbon products outside the aluminum industry were also reviewed since the work environment is similar to that ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/ajim.4700220412
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:Assess the national prevalence of current workplace exposure to potential skin hazards, secondhand smoke (SHS), and outdoor work among various industry and occupation groups. Also, assess the national prevalence of chronic workplace exposure to vapors, gas, dust, and fumes (VGDF) among these groups. METHODS:...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22089
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:In an effort to identify health and safety training needs for various groups of workers related to weapons of mass destruction, including chemical, biological, radiological, and nuclear weapons and high yield explosives (CBRNE), a conference, "Worker Training in a New Era: Responding to New Threats," was hel...
journal_title:American journal of industrial medicine
pub_type:
doi:10.1002/ajim.20091
更新日期:2004-11-01 00:00:00
abstract::This paper describes the development of an evaluative outcome measure for patients with upper extremity musculoskeletal conditions. The goal is to produce a brief, self-administered measure of symptoms and functional status, with a focus on physical function, to be used by clinicians in daily practice and as a researc...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0274(199606)29:6<602::AID-AJIM4
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:Nearly one of every three workers in the United States is low-income. Low-income populations have a lower life expectancy and greater rates of chronic diseases compared to those with higher incomes. Low- income workers face hazards in their workplaces as well as in their communities. Developing integrated pu...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22174
更新日期:2014-05-01 00:00:00
abstract:METHODS:We used a population-based sample of 403 Parkinson's disease cases and 405 controls to examine risks by occupation. Results were compared to a previous clinic-based analysis. RESULTS:With censoring of jobs held within 10 years of diagnosis, the following had significantly or strongly increased risks: social sc...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22272
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Autopsied lungs from 29 hard rock miners were investigated to determine the relationship of the dust content to pathology, radiology, and occupational exposure. METHODS:Each lung was divided horizontally into three sections. Pathological and radiological studies and chemical analyses were carried out on sam...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20589
更新日期:2008-07-01 00:00:00
abstract::Studies describing respiratory health hazards for workers in swine production facilities have been published in the United States, Sweden, Canada, the Netherlands, and Denmark. Up to 50% of these workers experience bronchitis, organic dust toxic syndrome, hyper-reactive airways disease, chronic mucous membrane irritat...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0274(199601)29:1<33::AID-AJIM5>
更新日期:1996-01-01 00:00:00
abstract::Lifetime industrial and occupational histories of women with a medically-confirmed diagnosis of infertility (n = 281) were compared to a group of postpartum women (n = 216) for risks of infertility. Controlling for age of first pregnancy or self-report of infertility, date of outcome, cigarette use, and employment in ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199704)31:4<445::aid-ajim1
更新日期:1997-04-01 00:00:00
abstract::To confirm the relationship between exposure to coal tar pitch volatiles and bladder cancer among primary aluminum production workers, we carried out a case-control study among blue-collar workers who had worked more than 1 year between 1950-1979 in a major plant using mostly the Soderberg process in the Province of Q...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700270303
更新日期:1995-03-01 00:00:00