Parkinson's disease and occupation: differences in associations by case identification method suggest referral bias.

Abstract:

METHODS:We used a population-based sample of 403 Parkinson's disease cases and 405 controls to examine risks by occupation. Results were compared to a previous clinic-based analysis. RESULTS:With censoring of jobs held within 10 years of diagnosis, the following had significantly or strongly increased risks: social science, law and library jobs (OR = 1.8); farming and horticulture jobs (OR = 2.0); gas station jobs (OR = 2.6); and welders (OR = 3.0). The following had significantly decreased risks: management and administration jobs (OR = 0.70); and other health care jobs (OR = 0.44). CONCLUSIONS:These results were consistent with other findings for social science and farming occupations. Risks for teaching, medicine and health occupations were not elevated, unlike our previous clinic-based study. This underscores the value of population-based over clinic-based samples. Occupational studies may be particularly susceptible to referral bias because social networks may spread preferentially via jobs.

journal_name

Am J Ind Med

authors

Teschke K,Marion SA,Tsui JK,Shen H,Rugbjerg K,Harris MA

doi

10.1002/ajim.22272

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

163-71

issue

2

eissn

0271-3586

issn

1097-0274

journal_volume

57

pub_type

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