Abstract:
:In 1982, White et al published an assessment of quantitative leukemia risk associated with lifetime occupational exposure to benzene. At about the same time, IARC (1982) published estimates of quantitative cancer risk associated with industrial chemicals. Benzene was one of the two chemicals selected by IARC for its risk estimation. This paper presents a summary of these assessments along with new study results demonstrating adverse effects on bone marrow and peripheral blood cells as a result of low-level benzene exposure. Mathematical extrapolations based on epidemiologic studies are consistent with a finding of significant risk of dying from leukemia under the current occupational permissible exposure limit of 10 ppm. Although a significant reduction of risk could be expected to be achieved by reducing exposure to 1 ppm, a significant risk may still remain. The uncertainty of the dose-response projections rests on the underlying estimates of relative risk of death from leukemia, the estimates of benzene exposure (dose), and the appropriateness of the mathematical model. Recent findings in experimental animals demonstrate chromosomal damage to bone marrow cells, significant depression of the bone marrow, and disturbances of immune system function as a result of less than 1 week of exposure to the current permissible benzene exposure limit of 10 ppm. This was the lowest dose tested. These experimental findings provide further evidence of a potentially significant risk of bone marrow proliferative cancer (leukemia) as a result of low-dose benzene exposure.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Infante PF,White MCdoi
10.1002/ajim.4700070507subject
Has Abstractpub_date
1985-01-01 00:00:00pages
403-13issue
5-6eissn
0271-3586issn
1097-0274journal_volume
7pub_type
杂志文章,评审abstract:BACKGROUND:There are few population-based studies addressing hypersensitivity pneumonitis (HP) in the United States. The National Institute for Occupational Safety and Health (NIOSH) has nationally comprehensive longitudinal mortality data that can contribute to a better understanding of the epidemiology of HP. METHOD...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20405
更新日期:2006-12-01 00:00:00
abstract::Very sensitive and precise analytical methods for measuring total porphyrin excretion and the relative amounts of different porphyrins in urine are required in order to monitor the biological effects of porphyrinogenic substances in workers and the general population. Many analytical steps of a HPLC method for measuri...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700040409
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:To assess whether unionization prevents deterioration in self-reported health and depressive symptoms in late career transitions. METHODS:Data come from the Health and Retirement Study (N = 6475). The change in self-perceived health (SPH) and depressive symptoms (CESD) between wave 11 and wave 12 is explaine...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22877
更新日期:2018-06-28 00:00:00
abstract:BACKGROUND:Work-related mortality is a relatively new concept which aims to widen occupational health and safety; to take into account not only recognized fatal occupational accidents and diseases but also other work-related deaths. Few countries in the world have a register for work-related diseases. METHODS:Estimate...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20411
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:We developed a systematic, data-driven approach to estimate metrics of occupational exposure to lead to aid in epidemiologic analyses in a case-control study of kidney cancer. METHODS:Probability of exposure to ten lead sources was assigned using decision rules developed from an extensive literature review ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22912
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Hotel room cleaners have physically demanding jobs that place them at high risk for shoulder pain. Psychosocial work factors may also play a role in shoulder pain, but their independent role has not been studied in this group. METHODS:Seventy-four percent (941 of 1,276) of hotel room cleaners from five Las ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20832
更新日期:2010-07-01 00:00:00
abstract::Among 160 consecutive patients referred to the Clinic of Occupational Medicine, Rigshospitalet, for symptoms connected with exposure to organic solvents, 20 exhibited symptoms of acquired intolerance to minor amounts of organic solvents. Later, an additional 30 consecutive patients with symptoms of acquired intoleranc...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700090408
更新日期:1986-01-01 00:00:00
abstract::The present report completes a previous study made on three chloralkali plants that was presented at the 8th International Conference on Occupational Health in the Chemical Industry, Tokyo, 1980, with the final results from five plants located in various regions of Italy. A total of 14,339 measurements of mercury in a...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700030308
更新日期:1982-01-01 00:00:00
abstract::Two workers (23 and 28 years old) developed rhinitis and bronchial asthma after occupational contact with the isocyanate MDI. Positive skin prick test results for MDI-HSA and IgE antibodies to all isocyanate-HSA conjugates were obtained in both cases, and the inhalation challenge test with MDI produced immediate and l...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0274(199605)29:5<467::AID-AJIM5
更新日期:1996-05-01 00:00:00
abstract::Several studies have indicated an increased risk for cancer of the urinary bladder among hairdressers. In a Danish linkage between census data and cancer register data both male and female hairdressers have an elevated risk for bladder cancer. The risk for lung cancer is close to unity, indicating that occupational fa...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700170206
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Construction workers move frequently from jobsite to jobsite, yet little is documented about length of stay on-site and associations with worker characteristics. METHOD:Using cross-sectional data, we investigated associations between worker characteristics (including trade and musculoskeletal pain) and leng...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22461
更新日期:2015-09-01 00:00:00
abstract::This report presents the findings of a case-control study of lung cancer among workers at a rubber manufacturing plant. Detailed work histories of 40 lung cancer deaths, which occurred during 1977 and 1978, were compared with those of 146 controls who were individually matched to cases on age, sex, and race; 66 of the...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700140507
更新日期:1988-01-01 00:00:00
abstract:INTRODUCTION:The prevalence of violence to first responders is reported in ranges of approximately 40% to 90%. Pennsylvania has a felonious assault statute to address such violence, but the prosecutorial process has been noted to cause first-responder dissatisfaction. METHODS:An exploratory qualitative study using ind...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.23036
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Polyvinyl chloride plastics (PVC), made flexible through the addition of di-2-ethylhexyl phthalate (DEHP), are used in the production of a wide array of medical devices. From the late 1960s, leaching of DEHP from PVC medical devices and ultimate tissue deposition have been documented. METHODS:A critical rev...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,meta分析
doi:10.1002/1097-0274(200101)39:1<100::aid-ajim10>3.0.
更新日期:2001-01-01 00:00:00
abstract::Dermatological disorders in athletes may occur as a result of repeated mechanical trauma, physical and chemical agents, climatic conditions, infections, infestations, and exacerbations of pre-existing skin disorders. These include black heel, tennis toe and other causes of subungual hemorrhage, friction blisters, abra...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700080422
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Multiple comorbidities have been reported among rescue/recovery workers responding to the 9/11/2001 WTC disaster. In this study, we developed an index that quantifies the cumulative physiological burden of comorbidities and predicts life expectancy in this cohort. METHODS:A machine learning approach (gradie...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22786
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Epichlorohydrin (ECH) is a strong irritant of the eyes, respiratory tract, and skin. The aims of this study were to examine the dose-response relationship between observed abnormal pulmonary function tests and respiratory tract irritation symptoms among epichlorohydrin-exposed workers in Taiwan. METHODS:A t...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10177
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Sensitivity to beryllium was investigated among workers at an aluminum smelter in Norway as a consequence of the findings in an occupational exposure survey. METHODS:Three hundred and sixty-two employees and 31 reference persons were tested for sensitization to beryllium with the beryllium lymphocyte prolif...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20816
更新日期:2010-07-01 00:00:00
abstract::To confirm the relationship between exposure to coal tar pitch volatiles and bladder cancer among primary aluminum production workers, we carried out a case-control study among blue-collar workers who had worked more than 1 year between 1950-1979 in a major plant using mostly the Soderberg process in the Province of Q...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700270303
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:Existing datasets often lack job exposure data. Standard Occupational Classification (SOC) codes can link work exposure data to health outcomes via a Job Exposure Matrix, but manually assigning SOC codes is laborious. We explored the utility of two SOC autocoding programs. METHODS:We entered industry and oc...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22928
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:This study estimates the annual cost of alcohol-related injuries to employers in 1998-2000. METHODS:Incidence was estimated with occupational injury data, motor vehicle crash data and health care data for 1998-2000. Employer costs were estimated from federal estimates of injury costs by source of payment us...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20425
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Production of asbestos-cement products in Brazil started in the 1940s, peaked in the 60-70s and is still an active industry. This study was designed to assess the non-malignant effects of asbestos exposure in the asbestos-cement industry in Brazil. METHODS:A group of 828 former asbestos-cement workers enrol...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.1095
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:The prerequisites necessary for attributing lung carcinoma to asbestos, represent a controversial issue. METHODS:Three parameters (occupational history, pleural plaques, and lung asbestos bodies) were investigated in 414 consecutive cases of lung carcinoma, examined at necropsy at the Hospital of Monfalcone...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199909)36:3<360::aid-ajim3
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVE:To investigate the one-year prevalence of musculoskeletal symptoms and associated risk factors in a large sample of Chinese workers in various industrial settings. METHODS:A total of 5,338 (3,632 males and 1,706 females) workers from 13 companies participated in this study. Musculoskeletal symptoms in differ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.21037
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:A program of medical evaluation for former Savannah River Site (SRS) workers at health effects due to exposures to hazardous or radioactive agents was conducted. METHODS:This study includes data from 1,368 participants aged 45 years or older who were assessed regarding work-history and exposures to industri...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20224
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:OSHA regulations require that workers receive medical clearance prior to respirator use, and recently, a detailed questionnaire has been provided to assist with this purpose. However, there are limited published data on the sensitivity and specificity of self-administered questionnaires for identifying indiv...
journal_title:American journal of industrial medicine
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0274(199904)35:4<395::aid-ajim1
更新日期:1999-04-01 00:00:00
abstract::Chest radiographs, taken at a 9-year interval for 1,261 U.S. coal miners, were read for pneumoconiosis side-by-side by six readers in a controlled trial. Incidence and progression of small, rounded opacities were consistent with levels predicted from dose-response curves developed by the British Pneumoconiosis Field R...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700060604
更新日期:1984-01-01 00:00:00
abstract::Highway maintenance workers (HMWs) have been exposed to a broad range of potentially toxic substances, including diesel fuels and exhaust, asphalts and tars, herbicides, gasoline, polynuclear aromatic hydrocarbons, benzene, and lead. The number of current and former state, county, and municipal HMWs in the United Stat...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700150507
更新日期:1989-01-01 00:00:00
abstract::To investigate the effects of styrene exposure on peripheral, central, and autonomic nervous system functions in man, we measured the distribution of nerve conduction velocities (DCV), short-latency somatosensory evoked potentials (SSEP), and variability in electrocardiographic R-R interval (CVRR) as well as conventio...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700200609
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:The purpose of the study was to evaluate trends in occupational lead exposures throughout U.S. industry after the establishment of the general industry lead standard in 1978 and the construction industry standard in 1993. METHODS:Lead exposure measurements collected by the Occupational Safety and Health Adm...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20008
更新日期:2004-06-01 00:00:00