Abstract:
BACKGROUND:Experimental and clinical evidence suggest that stress can lead to ill-health through the disregulation of the hypothalamic-pituitary-adrenal (HPA) axis. Studies to date have produced equivocal results likely due to different methodologies and failure to account for confounding factors. This investigation aimed to assess the relation between self-reported work-related stressors and salivary cortisol and to clarify the role of the potential confounders. METHODS:Thirty-six call-handlers completed a self-administered job content questionnaire and collected seven daily salivary samples on two workdays and a weekend. The diurnal salivary cortisol output was expressed as cortisol awakening response (CAR), and cortisol output in the rest of the day. Salivary cortisol data were normalized by means of square root transformation. The generalized estimating equations method was used to assess the relation between job strain and cortisol levels after adjusting for gender, weekdays and adherence to the sampling schedule. RESULTS:Job strain significantly influenced the total amount of cortisol response to waking (high strain vs. low strain: 1.1 (0.3-2.0) nmol/L). The cortisol response to waking showed gender-specific differences [women excreting greater cortisol than men: 1.1 (0.3-1.9) nmol/L], and weekday differences [workdays vs. weekend: 1.0 (0.3-1.6) nmol/L]. Non-compliance with the sampling protocol was associated with lower salivary cortisol than in adherent subjects. CONCLUSIONS:Our results provide further evidence for the HPA axis involvement in the physiological response to work stress. The measure of the CAR showed to be the sensitive index to assess the physiological response to psychosocial factors. Gender, weekday, and protocol compliance were confounding factors.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Maina G,Palmas A,Bovenzi M,Filon FLdoi
10.1002/ajim.20659subject
Has Abstractpub_date
2009-03-01 00:00:00pages
251-60issue
3eissn
0271-3586issn
1097-0274journal_volume
52pub_type
杂志文章abstract:BACKGROUND:No information exists on the differences between teenagers with work permits and teenagers without work permits in regards to workplace injury, near-miss incidents, and safety training. METHODS:In May 2003, an anonymous questionnaire was administered to 7,506 teens attending high school throughout the five ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20301
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journal_title:American journal of industrial medicine
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