Abstract：
:Studies of the immune response in chronic helminth infections suggest that parasites modulate the host's immune response. Taenia solium metacestodes, in particular, produce molecules that down-regulate cell-mediated immunity. We have described a small RNA peptide termed metacestode factor (MF) that depresses the murine immune response to Salmonella typhimurium antigens. MF inhibits mitogen-induced proliferation, humoral and cellular responses to metacestode antigens, and inflammation surrounding metacestodes implanted subcutaneously in mice. To assess the effects of MF on cytokine production we stimulated murine spleen cells in vitro with concanavalin A and measured cytokine concentrations in the culture supernatants by enzyme-linked immunosorbent assay. When cultured with MF, the cells showed significantly decreased production of interleukin 2 (IL-2), interferon-gamma (IFN-gamma), and IL-4 as compared with mitogen alone. Exogenous rIL-2 and rIL-4 largely restored the proliferative response (85% and 71% of control cells, respectively). MF also decreased production of tumor necrosis factor-alpha (TNF-alpha) by macrophages stimulated with lipopolysaccharide and IFN-gamma. The TNF-alpha concentration was inversely correlated with the MF concentration. Experiments using spleen cells from mice treated with MF also showed a significant reduction in IL-4 concentration. These results suggest that MF inhibits cytokine production without regard to cell type or cytokine. This may explain the function of this molecule as an inhibitor of the host inflammatory and immune responses.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Arechavaleta F,Molinari JL,Tato Pdoi
10.1007/s004360050367subject
Has Abstractpub_date
1998-01-01 00:00:00pages
117-22issue
2eissn
0932-0113issn
1432-1955journal_volume
84pub_type
杂志文章abstract：:Following the emergence of Schmallenberg virus (SBV) in 2011, 21,397 culicoid biting midges (Diptera: Ceratopogonidae) from targeted and non-targeted sampling activities carried out during the summer months of 2011 to 2013 and in late 2014 in various regions in Germany were analyzed for the virus by real-time RT-PCR. ...
journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
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journal_title：Parasitology research
pub_type： 历史文章,杂志文章,评审
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更新日期：2011-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
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journal_title：Parasitology research
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journal_title：Parasitology research
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2013-09-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2007-06-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章,评审
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更新日期：2009-08-01 00:00:00
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journal_title：Parasitology research
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章,评审
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journal_title：Parasitology research
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更新日期：2008-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2008-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-05-01 00:00:00
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journal_title：Parasitology research
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更新日期：2010-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-05-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2000-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2009-10-01 00:00:00
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journal_title：Parasitology research
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更新日期：2018-04-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-003-1015-2
更新日期：2004-01-01 00:00:00
