Abstract：
:Cytokine responses of lymphocytes against Toxoplasma gondii are usually studied by stimulating the cells from infected animals with tachyzoite lysate antigens (TLA) in vitro. We examined whether strains (genotypes) of the parasite used for TLA affect the production of IL-2, IL-4, IL-10 and IFN-gamma in the culture of spleen cells obtained from mice infected with the ME49 (type II) strain. The amounts of IL-2 and IL-4 detected in the culture supernatants following stimulation with TLA of the RH (type I) strain were significantly greater than those detected following stimulation with TLA of the ME49 strain at 2 and 4 weeks after infection, respectively. These results suggest that antigen variations among the strains of T. gondii affect cytokine production of lymphocytes of infected mice. Therefore, to obtain accurate information on cytokine production by immune lymphocytes of infected hosts, it is important to use the identical strain of T. gondii for both infection of animals and preparation of TLA to stimulate the lymphocytes in vitro.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Rodgers L,Wang X,Wen X,Dunford B,Miller R,Suzuki Ydoi
10.1007/s00436-005-1416-5subject
Has Abstractpub_date
2005-10-01 00:00:00pages
332-5issue
4eissn
0932-0113issn
1432-1955journal_volume
97pub_type
杂志文章abstract：:Litomosoides chagasfilhoi is a filariid nematode parasite of the abdominal cavity of the wild rodent Akodon cursor (Winge, 1887), that has been described and used in Brazil as a new model for human filariasis. The fine structure of the intestine of this nematode was analyzed based on observations made by light and tra...
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pub_type： 杂志文章
doi：10.1007/s00436-005-0092-9
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abstract：:For decades, drug resistance has been the major obstacle in the fight against malaria, and the search for new drugs together with the combination therapy constitutes the major approach in responding to this situation. The present study aims at assessing the in vitro antimalarial activity of four compounds isolated fro...
journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2012-02-01 00:00:00
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journal_title：Parasitology research
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
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更新日期：2005-09-01 00:00:00
abstract：:Although cystic echinococcosis (CE) has been a recognized public health problem in Greece, molecular data are lacking regarding the types and prevalences of infecting strains of the etiological agent Echinococcus granulosus. Therefore, we investigated the prevalence of CE and determined the infecting genotypes in shee...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0568-x
更新日期：2007-09-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00535143
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更新日期：2017-04-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-018-6024-2
更新日期：2018-10-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2013-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00436-010-2144-z
更新日期：2011-04-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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journal_title：Parasitology research
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journal_title：Parasitology research
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章,评审
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