Abstract：
:Serine proteinases secreted by adult Trichinella spiralis were isolated from excretory/secretory products (ES) of in-vitro-cultured parasites by affinity chromatography with p-benzamidine-celite. The purified enzymes had molecular weights of approximately 18, 40, and 50 kDa and displayed enzyme activity against a range of low-molecular-weight substrates, gelatin, and azocasein. The antigenicity of these parasite proteinases was demonstrated by the inhibition of enzymatic activity with IgG purified from infected hosts. The inactivation of major secreted proteinases of adult T. spiralis by immune antibody could presumably contribute to impairment of the survival of the parasite in sensitized hosts.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Todorova VK,Stoyanov DIdoi
10.1007/pl00008552subject
Has Abstractpub_date
2000-08-01 00:00:00pages
684-7issue
8eissn
0932-0113issn
1432-1955journal_volume
86pub_type
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