Abstract:
:The localisation and distribution of the cytoskeletal protein tubulin in the adult liver fluke Fasciola hepatica have been determined by an indirect immunofluorescence technique using a monoclonal antibody raised against beta-tubulin. Tubulin was demonstrated in the tegumental syncytium and in the tegumental cell bodies and their cytoplasmic connections with the surface syncytium. Immunostaining was also evident in the nerve fibres innervating sensory receptors in the tegument, in the nerve plexus innervating the sub-tegumental musculature and in the cytoplasmic extensions of the nurse cells within the vitelline follicle. Immunoblotting of whole fluke fractions produced a single band corresponding to a molecule of approximately 54 kDa in size. This figure corresponds with previous data obtained on tubulin from other helminth and eukaryotic sources.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Stitt AW,Fairweather I,Trudgett AG,Johnston CFdoi
10.1007/BF00931649subject
Has Abstractpub_date
1992-01-01 00:00:00pages
103-7issue
2eissn
0932-0113issn
1432-1955journal_volume
78pub_type
杂志文章abstract::Praziquantel, due to high efficacy, excellent tolerability, few and transient side effects, simple administration, and competitive cost, is virtually the only drug of choice for treatment of human schistosomiasis. Treatment of schistosomiasis has shown great advances with the introduction of the drug into the therapeu...
journal_title:Parasitology research
pub_type: 杂志文章,评审
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journal_title:Parasitology research
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更新日期:2015-11-01 00:00:00
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journal_title:Parasitology research
pub_type: 杂志文章
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journal_title:Parasitology research
pub_type: 杂志文章
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journal_title:Parasitology research
pub_type: 杂志文章
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abstract::DNA plasmid immunization is a novel approach of preventive and therapeutic vaccine. More than 100 DNA vaccines have been on preclinical or clinical phase trials, and four kinds of DNA vaccines for livestock have been approved by USDA, CFIA, and APVMA. Schistosomiasis is a worldwide parasitic disease, and vaccine immun...
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pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-12 00:00:00
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journal_title:Parasitology research
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journal_title:Parasitology research
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journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-020-07021-7
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更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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journal_title:Parasitology research
pub_type: 杂志文章
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journal_title:Parasitology research
pub_type: 杂志文章
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