Bacteriocin-like substance from Bacillus amyloliquefaciens shows remarkable inhibition of Acanthamoeba polyphaga.

Abstract:

:The effectiveness of a bacteriocin-like substance (BLS) produced by Bacillus amyloliquefaciens was tested against Acanthamoeba polyphaga strains, and its cytotoxic potential on Vero cells was investigated. Amebicidal activity of the purified BLS was tested by plate bioassays with concentrations ranging from 12.5 to 6,400 AU mL(-1). Damage to A. pholyphaga cells was monitored using an inverted microscope and counted in a Fuchs-Rosenthal chamber after 24, 48, and 72 h. According to the results obtained, the BLS showed remarkable amebicidal and amebostatic effect on A. polyphaga and showed no cytotoxicity on the Vero cells. These results may have great relevance in the development of new acanthamoebicidal compounds.

journal_name

Parasitol Res

journal_title

Parasitology research

authors

Benitez LB,Caumo K,Brandelli A,Rott MB

doi

10.1007/s00436-010-2114-5

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

687-91

issue

3

eissn

0932-0113

issn

1432-1955

journal_volume

108

pub_type

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