Babesia bovis: vaccination studies with three groups of high molecular weight antigens from lysate of infected erythrocytes.

Abstract:

:A void volume fraction and fractions of mean sizes 800 kdalton and 300 kdalton were isolated by gel filtration from lysate of bovine erythrocytes infected with Babesia bovis. All fractions had good serological activity, as assayed by ELISA and IFA. Groups of four splenectomized calves were vaccinated with each fraction and then challenged, together with groups of four control calves, with a homologous strain of B. bovis. The group vaccinated with the 300 kdalton fraction showed some protection, as indicated by delayed and significantly lower parasitaemias and by a 75% survival in the group. In contrast, all animals in the relevant control group died from infection. No evident protection was obtained with the other two fractions.

journal_name

Parasitol Res

journal_title

Parasitology research

authors

Waltisbuhl DJ,Goodger BV,Wright IG,Mirre GB,Commins MA

doi

10.1007/BF00531085

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

319-23

issue

4

eissn

0932-0113

issn

1432-1955

journal_volume

73

pub_type

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