Abstract：
:Tryptophan-N-formylated gramicidin A, a nonhemolytic derivative of the toxic peptide antibiotic gramicidin A, has previously been shown to induce potassium leakage from Plasmodium falciparum-infected erythrocytes in vitro and to inhibit the growth of the parasite. In the present study the antimalarial activities of two other nonhemolytic derivatives of gramicidin A, viz., acylated gramicidin A and desformylated gramicidin A, were tested and compared with those of gramicidin A and tryptophan-N-formylated gramicidin A. The 50% growth-inhibitory concentrations (IC50 values) of the four compounds varied from 0.3 to 18.3 nM, and complete growth inhibition was detected within one parasitic growth cycle. Using highly synchronized cultures of P. falciparum, it was furthermore shown that the gramicidin analogs are inhibitory to all developmental stages of the parasite, although their efficiency in accomplishing growth inhibition was found, as expected, to be clearly stage-dependent and to increase with the age of the parasite.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Otten-Kuipers MA,Roelofsen B,Op den Kamp JAdoi
10.1007/BF00932413subject
Has Abstractpub_date
1995-01-01 00:00:00pages
26-31issue
1eissn
0932-0113issn
1432-1955journal_volume
81pub_type
杂志文章abstract：:The present investigation was undertaken to identify and characterize trophozoite proteases of five axenic strains of Giardia duodenalis isolated in Brazil and the reference strain Portland 1 isolated in the United States. Trophozoite cell lysates of each strain were analysed for the pattern of proteins and for proteo...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-005-0124-5
更新日期：2006-07-01 00:00:00
abstract：:In the gastrointestinal mucosa, mucus produced by goblet cells plays an important role in the defense against various pathogens. It is well known that some helminth parasites are able to up-regulate goblet cell numbers and alter the mucus components. However, the nature of the interactions between the protozoan parasi...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-008-1256-1
更新日期：2009-03-01 00:00:00
abstract：:Serum and colostrum were collected from adult buffalo cows naturally infected with Toxocara vitulorum. When injected into mice, the colostrum reduced the number of larvae of T. vitulorum that migrated in the mice. Injection of particularly the IgG-containing fraction but also the IgM-containing fraction of Sephadex G2...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00932381
更新日期：1994-01-01 00:00:00
abstract：:Due to the global health problems associated with mosquito-borne diseases, over two million people primarily in the tropical countries are at risk. The widely and commonly used chemical method though effective, has some major disadvantages making insect control practically difficult. In view of the above, it is unavoi...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-011-2261-3
更新日期：2011-08-01 00:00:00
abstract：:Free living amoebae (FLA) are protists ubiquitously present in the environment. Aspergillus fumigatus is a mould responsible for severe deep-seated infections, and that can be recovered in the same habitats as the FLA. By conducting coculture experiments and fungal incubation with amoebal supernatants, we report herei...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-016-5182-3
更新日期：2016-11-01 00:00:00
abstract：:Allicin is an active ingredient of garlic that has antibacterial, antifungal, antiviral, and antiprotozoal activity. However, the inhibitory effects of allicin on Babesia parasites have not yet been examined. In the present study, allicin was tested as a potent inhibitor against the in vitro growth of bovine and equin...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3654-2
更新日期：2014-01-01 00:00:00
abstract：:Ligictaluridus michaelalicea n. sp. (Monogenea: Dactylogyridae, Ancyrocephalinae) is described from the gills of Pylodictis olivaris (Siluriformes: Ictaluridae) from Wisconsin and Iowa portions of the upper Mississippi River. Diagnostic features include a relatively large, strongly curved tubular cirrus with minor ter...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-018-5757-2
更新日期：2018-03-01 00:00:00
abstract：:Reports of an unusual intraerythrocytic pathogen in amphibian blood have been made for decades; these pathogens appear as membrane-bound vacuoles within erythrocytes. It is now understood that the pathogen is a Rickettsia bacteria, which are obligate intracellular parasites, and most are transmitted by arthropod vecto...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-1869-z
更新日期：2010-07-01 00:00:00
abstract：:Representatives of Apicomplexa perform various kinds of movements that are linked to the different stages of their life cycle. Ancestral apicomplexan lineages, including gregarines, represent organisms suitable for research into the evolution and diversification of motility within the group. The vermiform trophozoites...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-019-06381-z
更新日期：2019-09-01 00:00:00
abstract：:Diversity in parasite virulence is one of the factors that contribute to the clinical outcome of malaria infections. The association between the severity of Plasmodium falciparum malaria and the number of distinct parasite populations infecting the host (multiplicity of infection) or polymorphism within any of the spe...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3325-3
更新日期：2013-04-01 00:00:00
abstract：:The nematode Teladorsagia circumcincta is a polymorphic species, morphs T. c. trifurcata and T. c. circumcincta being the most frequent. Among other traits, T. c. trifurcata has lower infectivity than T. c. circumcincta. Anthelmintic treatments that regularly remove populations should favour the more infective T. c. c...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360100387
更新日期：2001-09-01 00:00:00
abstract：:An inexpensive and simple method using acid-phenol was developed for the isolation of total RNA from eimerian oocysts. This procedure provides a pure preparation of undegraded RNA in high yield and can be completed in under 2 h. ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050446
更新日期：1998-07-01 00:00:00
abstract：:Two placebo-controlled pen studies were conducted to assess the efficacy of an imidacloprid 10 %/flumethrin 4.5 % polymer matrix collar (Seresto®, Bayer; Investigational Veterinary Product (IVP)) against the Australian paralysis tick (Ixodes holocyclus). Dogs assigned to the placebo (n = 8) or IVP (n ≥ 8) groups had c...
journal_title：Parasitology research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00436-013-3276-8
更新日期：2013-08-01 00:00:00
abstract：:In Egypt, reclaiming portions of the desert using water from the Nile has resulted in large-scale invasion of Biomphalaria alexandrina in these regions. Studies exploring the local adaptation of Schistosoma mansoni to its snail host have been carried out to predict the extension of schistosomiasis to newly reclaimed a...
journal_title：Parasitology research
pub_type： 杂志文章,meta分析
doi：10.1007/s00436-014-3756-5
更新日期：2014-03-01 00:00:00
abstract：:Gyrodactylus bubyri Osmanov, 1965, a monogenean parasite of Caucasian dwarf goby Knipowitschia caucasica (Berg) described from Aral Sea and subsequently reported from the same host from Strymon River, Greece, is recorded from Atanasovsko Lake, Bulgarian Black Sea coast (the first record of G. bubyri from the Black Sea...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-015-4899-8
更新日期：2016-04-01 00:00:00
abstract：:Blastocystis spp., one of the most common parasites colonizing the human intestine, is an extracellular, luminal protozoan with controversial pathogenesis. The host's immune response against Blastocystis spp. infection has also not been defined yet. Therefore, this research aimed to assess the potential pathogenicity ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-016-4951-3
更新日期：2016-05-01 00:00:00
abstract：:An in vitro system for studying the transformation of bloodstream forms of Trypanosoma brucei brucei into procylic (midgut) forms is described. In this system, transformation of the parasites was stimulated by Glossina morsitans morsitans midgut homogenates at 27 degrees C but not at 4 degrees C. The transformation-st...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00936174
更新日期：1992-01-01 00:00:00
abstract：:The invasive fish tapeworm, Khawia japonensis (Yamaguti, 1934) originally described in Japan, is reported for the first time in Slovakia. The tapeworm was found in farmed common carp (Cyprinus carpio L.) from East-Slovakian breeding fish pond. This finding is registered 4 years after the first announcement of this par...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-015-4447-6
更新日期：2015-05-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-003-0987-2
更新日期：2003-12-01 00:00:00
abstract：:Over a 4-year period, we analyzed 128 fecal samples from free-living elk (Alces alces L., 1758) to determine the prevalence of Eimeria infections and identify the species present. Two eimerian species were isolated including Eimeria alces and a morphotype resembling Eimeria catubrina. Overall, two samples from 128 sam...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-3262-6
更新日期：2013-05-01 00:00:00
abstract：:Discoid granules were isolated from the tegument of adult Schistosoma mansoni by differential centrifugation of freeze-thaw extracts. Comparison of proteins and glycoproteins from discoid granules, surface membranes and the soluble fraction implied that discoid granules and the surface membrane were functionally linke...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00539573
更新日期：1988-01-01 00:00:00
abstract：:Equine ocular setariasis arising mainly from ectopic infestation of Setaria digitata is a common vision impairing ophthalmic disease in India, and the identification of this filarial nematode is based solely on morphology. However, morphological characters alone are inadequate to detect and differentiate S. digitata f...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-019-06587-1
更新日期：2020-02-01 00:00:00
abstract：:This study assessed the anisakid nematode distribution pattern in the fish collected from coasts of Mediterranean Sea, Egypt, during the period September 2010-April 2011. Two hundred thirty out of 300 (76.7%) Dicentrarchus labrax (European seabass) marine fishes belonging to family Moronidae were dissected and found t...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-011-2600-4
更新日期：2012-03-01 00:00:00
abstract：:The genomic DNA was extracted from nematode parasites, Heterakis gallinae from specific host, native chickens. The polymerase chain reaction (PCR) was applied to make amplification of the DNA content that aids in the further studies. The primer was used in the PCR reactions that have the following sequences: forward (...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3539-4
更新日期：2013-10-01 00:00:00
abstract：:The present study represents the first detailed description of the haptoral sclerites of Macrogyrodactylus clarii Gussev 1961. Light microscopy reveals outgrowths of the hamuli roots; two lateral spine-like extensions of the hood-like accessory sclerites; a ridged, fan-shaped distal end of an accessory sclerite; and t...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-020-06799-w
更新日期：2020-12-01 00:00:00
abstract：:Protoscolices of Echinococcus granulosus were incubated in vitro with praziquantel (PZ), albendazole (ABZ), or a combination of both (PZ + ABZ). PZ and ABZ displayed slower protoscolicidal activity when applied separately than when used in combination. Despite the low PZ + ABZ concentrations used, protoscolex viabilit...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/pl00008526
更新日期：2000-12-01 00:00:00
abstract：:A substitution (Phe-->Ile) within the sodium channel gene sequence has been associated with pyrethroid resistance in Boophilus microplus. The aim of the present study was to analyze the inheritance of pyrethroid resistance and the mutant allele, on reciprocal crosses of a susceptible (SS) and a resistant (RR) strain. ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-008-1024-2
更新日期：2008-08-01 00:00:00
abstract：:Feasibility of implementing a DEC-fortified (DEC at 0.2% w/w and iodine) salt strategy to hasten elimination of diurnally sub-periodic Wuchereria bancrofti (DspWB) from the lone foci in Nancowry islands, Nicobar district, India, was assessed. This is a two-arm community-based study: one arm (12 villages, population 29...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-020-06659-7
更新日期：2020-05-01 00:00:00
abstract：:The anti-plasmodial activity of different solvent extracts of Adhatoda vasica (root), Caesalpinia pulcherrima (leaf), Carica papaya (pulp), Erythroxylum monogynum (leaf), Lantana camara (whole plant), Ocimum sanctum (root) and Phyllanthus niruri (whole plant) were studied against Plasmodium falciparum. Of the 35 extra...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-2834-9
更新日期：2012-07-01 00:00:00
abstract：:Blastocytis sp. is the most common enteric protozoan in human, but its pathogenesis is still unclear. To study the infectious effects of Blastocytis sp. on tissue damage, we orally challenged the Sprague Dawley (SD) rats with different doses of Blastocytis subtype1 (ST1) and examined the histological changes. We found...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3536-7
更新日期：2013-10-01 00:00:00
