In vitro anti-plasmodial activity of some traditionally used medicinal plants against Plasmodium falciparum.

Abstract:

:The anti-plasmodial activity of different solvent extracts of Adhatoda vasica (root), Caesalpinia pulcherrima (leaf), Carica papaya (pulp), Erythroxylum monogynum (leaf), Lantana camara (whole plant), Ocimum sanctum (root) and Phyllanthus niruri (whole plant) were studied against Plasmodium falciparum. Of the 35 extracts tested, seven extracts showed good anti-plasmodial activity. Methanol extract of C. pulcherrima showed the lowest IC50 value (10.96 μg/mL) followed by methanol extract of A. vasica (IC(50)=11.1 μg/mL), chloroform extract of O. sanctum (IC(50)=11.47 μg/mL), methanol extract of E. monogynum (IC(50)=12.23 μg/mL), acetone extract of C. pulcherrima (IC(50)=12.49 μg/mL), methanol extract of O. sanctum and acetone extract of A. vasica (IC(50)=14.04 μg/mL). The results of the present study justify the use of these medicinal plants in traditional practice, and also, a further study on the isolation of anti-plasmodial molecules from their active crude extracts is in progress.

journal_name

Parasitol Res

journal_title

Parasitology research

authors

Venkatesalu V,Gopalan N,Pillai CR,Singh V,Chandrasekaran M,Senthilkumar A,Chandramouli N

doi

10.1007/s00436-012-2834-9

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

497-501

issue

1

eissn

0932-0113

issn

1432-1955

journal_volume

111

pub_type

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