Abstract：
:Snake venom can affect the growth of Trypanosoma cruzi and Leishmania spp. As new classes of therapeutic drugs against protozoan parasites could be derived from snake venom, alterations in the ultrastructure and growth of the epimastigotes, trypomastigotes and amastigotes of T. cruzi, as well as the promastigotes of Leishmania major, were analyzed after treatment with crude venom from Bothrops jararaca. Parasite growth (epimastigotes and promastigotes) of venom treated cultures showed a negative correlation between cell growth and venom concentration. No growth occurred at a dose of 100 microg/ml of venom, while 50% growth inhibition was obtained in the range 0.1-0.3 microg/ml. Ultrastructural observations of treated bloodstream trypomastigotes, intracellular amastigotes, as well as axenic cultures of epimastigotes and promastigotes, demonstrated mitochondrial swelling and kinetoplast disorganization. Our data show that B. jararaca venom effectively inhibited the growth of T. cruziand L. major parasites. Growth inhibition was probably related to mitochondrial impairment.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Gonçalves AR,Soares MJ,de Souza W,DaMatta RA,Alves EWdoi
10.1007/s00436-002-0626-3subject
Has Abstractpub_date
2002-07-01 00:00:00pages
598-602issue
7eissn
0932-0113issn
1432-1955journal_volume
88pub_type
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