Abstract:
:Malaria recurrences after an initially successful therapy and malarial fever occurring a long time after infection are well-known problems in malariology. Currently, two distinct types of malaria recurrences are defined: recrudescence and relapse. A recrudescence is thought to originate from circulating Plasmodium blood stages which do not cause fever before a certain level of a microscopically detectable parasitemia is reached. Contrary, a relapse is thought to originate from quiescent intracellular hepatic parasite stages called hypnozoites. Recrudescences would typically occur in infections due to Plasmodium falciparum. Plasmodium knowlesi, and Plasmodium malariae, whereas relapses would be caused exclusively by Plasmodium vivax and Plasmodium ovale. This schematic view is, however, insufficiently supported by experimental evidence. For instance, hypnozoites of P. ovale have never been experimentally documented. On the other hand, the nonfinding of P. malariae hypnozoites turned into the proof for the nonexistence of P. malariae hypnozoites. Clinical relapse-type recurrences have been observed in both P. ovale and P. malariae infections, and decade-long incubation times have also been reported in P. falciparum infections. We propose a gradual hypothesis in accordance with the continuity concept of biological evolution: both, relapse and recrudescence may be potentially caused by all Plasmodium spp. We hypothesize that the difference between the various Plasmodium spp. is quantitative rather than qualitative: there are Plasmodium spp. which frequently cause relapses such as P. vivax, particularly the P.v. Chesson strain, species which cause relapses less frequently, such as P. ovale and sometimes P. malariae, and species which may exceptionally cause relapses such as P. falciparum. All species may cause recrudescences. As clinical consequences, we propose that 8-aminquinolines may be considered in a relapse-type recrudescence regardless of the causal Plasmodium sp., whereas primaquine relapse prevention might not be routinely indicated in malaria due to P. ovale.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Richter J,Franken G,Holtfreter MC,Walter S,Labisch A,Mehlhorn Hdoi
10.1007/s00436-016-5043-0subject
Has Abstractpub_date
2016-06-01 00:00:00pages
2139-48issue
6eissn
0932-0113issn
1432-1955pii
10.1007/s00436-016-5043-0journal_volume
115pub_type
杂志文章,评审abstract::The C57BL/6J strain of Mus musculus is susceptible to the terrestrial trematode Brachylaima cribbi. The duration of infection in these mice is generally 9-12 weeks with a peak excretion of eggs at 4 weeks post-infection (wpi). The effects of age and sex on the course of infection were investigated by comparing infecti...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-002-0642-3
更新日期:2002-07-01 00:00:00
abstract::Levamisole phosphate, chosen based on its 100 % efficacy demonstrated by a previous fecal egg count reduction test (FECRT), was used as the exclusive anthelmintic treatment in the Embrapa Southeast Livestock sheep flock from 2009 to 2014 in a target selected treatment scheme. In the present study, the effectiveness of...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-015-4844-x
更新日期:2016-03-01 00:00:00
abstract::The present study represents the first detailed description of the haptoral sclerites of Macrogyrodactylus clarii Gussev 1961. Light microscopy reveals outgrowths of the hamuli roots; two lateral spine-like extensions of the hood-like accessory sclerites; a ridged, fan-shaped distal end of an accessory sclerite; and t...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-020-06799-w
更新日期:2020-12-01 00:00:00
abstract::In life cycle of Angiostrongylus costaricensis, veronicellidae mollusks participate as the invertebrate host while rodents as the main vertebrate host. The current work shows a sequential larval development of A. costaricensis in Sarasinula marginata, individually killed and digested from day 1 to 43, post infection. ...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-007-0834-y
更新日期:2008-04-01 00:00:00
abstract::The genus Plasmodium (Plasmodiidae) ranks among the most widespread intracellular protozoan parasites affecting a wide range of mammals, birds, and reptiles. Little information is available about lizard malaria parasites in South America, and the pathological features of the resulting parasitoses remain unknown or poo...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-020-06756-7
更新日期:2020-08-01 00:00:00
abstract::Non-invasive diagnoses for most of the extraintestinal helminth infections among vertebrates are rare. In the present study, we developed and tested a non-invasive visual diagnosis method to detect the infection of the nematode Philometra ovata, which is parasitising in the body cavity of the common minnow Phoxinus ph...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-012-3099-z
更新日期:2012-12-01 00:00:00
abstract::In 1978, the nature of the hypnozoite was discussed in an article that appeared in a relatively obscure journal, which is also where the term was adopted for Plasmodium (a little-known fact). As a result, that commentary on the use of the word "hypnozoite" has been almost completely overlooked. Although the publicatio...
journal_title:Parasitology research
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s00436-010-2072-y
更新日期:2011-01-01 00:00:00
abstract::Angiostrongylus vasorum is a metastrongyloid nematode that may cause cardiopulmonary disease, neurological signs and coagulopathies in dogs. The parasite has an indirect life cycle with molluscs as intermediate hosts, in which the infective third larval stage develops. Recently, A. vasorum has been repeatedly reported...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-013-3532-y
更新日期:2013-10-01 00:00:00
abstract::Acetylcholinesterase (AChE) is a key enzyme involved in nerve impulse transmission in both vertebrates and invertebrates. In addition to neuromuscular AChE, many parasitic nematodes synthesize AChE in secretory glands and release the enzyme into their external environment. In this study, we evaluate the activities of ...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-014-3878-9
更新日期:2014-06-01 00:00:00
abstract::The Qinghai-Tibetan Plateau (QTP, in western China), which is the largest and highest plateau on Earth, is a highly epidemic region for Echinococcus spp. We collected 70 Echinococcus samples from humans, dogs, sheep, yaks, plateau pikas, and voles in eastern and southern Qinghai and genotyped them using the mitochondr...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-012-2815-z
更新日期:2012-07-01 00:00:00
abstract::In this study, we compared and validated a nested ABC polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay to amplify Cryptosporidium parvum oocyst wall protein (COWP) gene fragment with a previous nested PCR-RFLP method. When RFLP of COWP gene did not provide clear results, we further a...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-008-1233-8
更新日期:2009-02-01 00:00:00
abstract::Sarcocystis neurona is the parasite associated with equine protozoal myeloencephalitis (EPM). Recently, cats (Felis domesticus) have been implicated as a potential intermediate host in the life cycle of S. neurona. This study was initiated to determine whether cats have antibodies that react to S. neurona antigens sim...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s004360100503
更新日期:2002-01-01 00:00:00
abstract::In the present study, we described a new species of Myxidium Bütschli, 1882, obtained from the gallbladder of Spinibarbus sinensis (Bleeker, 1871) from the Jialing River in Chongqing, China. Myxidium spinibarba sp. nov. was identified based on morphological and SSU rDNA sequence data. The mature myxospores were fusifo...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-020-06644-0
更新日期:2020-05-01 00:00:00
abstract::Angiostrongyliasis caused by Angiostrongylus cantonensis (A. cantonensis) is an emerging food-borne parasitic disease, which refers basically to eosinophilic meningitis. Chitinase-like protein 3 (Chil3), a member of chitinase-like protein family which has chemotactic activity for eosinophils, is reported to be highly ...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-016-5135-x
更新日期:2016-10-01 00:00:00
abstract::The recombinant surface protein of Theileria annulata (TaSP) was used in the standardization and validation of an enzyme linked immunosorbent assay (ELISA) for the detection of circulating antibodies against tropical theileriosis. ELISA data were expressed as the percentage positivity (PP) of the reactivity of an inte...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-003-1055-7
更新日期:2004-03-01 00:00:00
abstract::Ligictaluridus michaelalicea n. sp. (Monogenea: Dactylogyridae, Ancyrocephalinae) is described from the gills of Pylodictis olivaris (Siluriformes: Ictaluridae) from Wisconsin and Iowa portions of the upper Mississippi River. Diagnostic features include a relatively large, strongly curved tubular cirrus with minor ter...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-018-5757-2
更新日期:2018-03-01 00:00:00
abstract::Trypanosoma cruzi causes Chagas' disease, a systemic infection that affects cells of meso-, endo-, and ectodermic origin. However, as far as we know, the presence of T. cruzi stages in bone has not been reported previously, and it has scarcely been investigated in cartilage. We inoculated 7- and 20-day-old (8 and 15 g...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-006-0211-2
更新日期:2006-11-01 00:00:00
abstract::Echinostoma trivolvis adults grown in golden hamsters were treated in vitro with [3H]-tyrosine to label sperm and transplanted to uninfected hamsters alone or with four to six unlabeled adults. After 4-5 days, worms were recovered, processed for autoradiography, and observed for silver grains over their seminal recept...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/BF00932258
更新日期:1993-01-01 00:00:00
abstract::The protozoan parasite Giardia duodenalis is known to infect humans and a wide range of animals globally. However, no studies on G. duodenalis infection in Bactrian camels have been reported. In the present study, in order to examine the prevalence and genetic diversity of G. duodenalis in Bactrian camels, 852 fecal s...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-020-06905-y
更新日期:2020-11-01 00:00:00
abstract::To determine the prevalence of endoparasites and their association with diarrhea, a survey was conducted in the Southern Province of Zambia that used conventional and molecular techniques applied to stool and urine samples from school-age children (n = 93). Almost half of the stools (49.5%) were diarrhetic. The overal...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-005-0003-0
更新日期:2005-12-01 00:00:00
abstract::The uptake of amino acids is mediated by active transporters located on the basolateral and brush border membranes of intestinal epithelial cells. The current study investigated the expression of amino acid transporters (AAT) and other genes in the intestine of chicks infected with Eimeria maxima. At 7-day postinfecti...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-014-4114-3
更新日期:2014-10-01 00:00:00
abstract::Vector control is facing a threat due to the emergence of resistance to synthetic insecticides. Insecticides of plant origin my serve as an alternative biocontrol technique in the future. The aim of the present study was to evaluate the larvicidal activity of fractions and compounds from the whole-plant methanol extra...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-015-4856-6
更新日期:2016-03-01 00:00:00
abstract::In the present study, we sequenced and analyzed the mitochondrial (mt) genome of Gastrothylax crumenifer and compared it with other selected trematodes. The full mt genome of G. crumenifer was amplified, sequenced, assembled, analyzed and then subjected to phylogenetic analysis. The complete mt genome of G. crumenifer...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-016-5019-0
更新日期:2016-06-01 00:00:00
abstract::Under natural conditions, eukaryote cells may contain bacteria. Arthropods such as ticks, insects or mites are a group particularly favoured by the obligate intracellular bacteria. While arthropods are vectors for some of them, other bacteria inhabit invertebrate host cells having entered mutualistic interactions. Suc...
journal_title:Parasitology research
pub_type: 杂志文章,评审
doi:10.1007/s00436-006-0412-8
更新日期:2007-04-01 00:00:00
abstract::Two thousand four hundred fifty-eight fish comprised of 53 species were captured in the Danjiangkou Reservoir, in the northwestern part of Hubei Province, central China during 2004, to examine Camallanus cotti infections. We found that 19 cypriniform, 3 siluriforme, and 4 perciforme fishes were infected by the nematod...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-007-0472-4
更新日期:2007-07-01 00:00:00
abstract::The aim of the study is to understand the anti-Clonorchis sinensis properties of mebendazole and albendazole, and compare to praziquantel and tribendimidine. Two hundred and thirty rats were divided into five batches for experimental treatment. In four batches, each rat was infected orally with 50 or 100 C. sinensis m...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-010-2187-1
更新日期:2011-03-01 00:00:00
abstract::Sarcophagids are a large family of Diptera, with a worldwide distribution. They are related to decomposing organic matter and are very interesting for health science and in forensic cases since many species produce myiasis and occur in human corpses. This family is considered difficult to study, particularly with rega...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-015-4631-8
更新日期:2015-11-01 00:00:00
abstract::Infections of Eimeria tenella in chicken embryos were used to compare the anticoccidial activity of ten drugs. The minimal inhibitory concentration (MIC) and minimal toxic concentration (MTC) were affected by the time of inoculation into the embryos and by the chemical nature of the compounds. Some compounds (nicarbaz...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/BF00931020
更新日期:1991-01-01 00:00:00
abstract::The involvement of protein kinase C in the initiation of free oxygen radical generation by rat leukocytes in response to the nematode Nippostrongylus brasiliensis was investigated. Inhibitors of protein kinase C, trifluoperazine and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7), inhibited free radical generatio...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/BF00928421
更新日期:1991-01-01 00:00:00
abstract::The purpose of this study was to evaluate morphologically the tongue of individuals with chronic Chagas disease (CD) in comparison to the non-chagasic ones. Twenty-four protocol cases of autopsies were selected. They were subdivided into CD patients (10 cases) and non-chagasic ones (14 cases). The morphometric analysi...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-005-0023-9
更新日期:2006-01-01 00:00:00