Abstract：
:Angiostrongyliasis caused by Angiostrongylus cantonensis (A. cantonensis) is an emerging food-borne parasitic disease, which refers basically to eosinophilic meningitis. Chitinase-like protein 3 (Chil3), a member of chitinase-like protein family which has chemotactic activity for eosinophils, is reported to be highly upregulated in brain of mouse infected with A. cantonensis. The mechanisms of high expression of Chil3 and the association between A. cantonensis and Chil3 are rarely reported. In order to understand the mechanism of high expression of Chil3 in A. cantonensis-infected mouse, we measured the level of Chil3 in RAW 264.7 and BV2 cell lines stimulated with soluble antigen of A. cantonensis by qPCR and ELISA. To explore the role of Chil3 in inflammation caused by A. cantonensis, we extracted and cultured brain mononuclear cells (BMNCs) and detected the eosinophil chemotactic activity of Chil3 using transwell assay and flow cytometer. Furthermore, we treated the infected mice by injection with rmChil3 and then counted the number of larvae in brains of infected mice and treated mice to examine the association between the worm and Chil3. Our results showed the soluble antigen from A. cantonensis could promote the Chil3 expression in macrophage and microglial cell lines induced by interleukin-13. In conclusion, we supposed that high expression of Chil3 enhanced by soluble antigens from A. cantonensis might be the reason of serious eosinophil infiltration in mouse brain after A. cantonensis infection.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Wu F,Wei J,Liu Z,Zeng X,Yu Z,Lv Z,Sun X,Wu Zdoi
10.1007/s00436-016-5135-xsubject
Has Abstractpub_date
2016-10-01 00:00:00pages
3737-46issue
10eissn
0932-0113issn
1432-1955pii
10.1007/s00436-016-5135-xjournal_volume
115pub_type
杂志文章abstract：:Hysterothylacium zhoushanensis sp. nov. collected from the intestine of the flatfish Pseudorhombus oligodon (Bleeker) (Pleuronectiformes: Paralichthyidae) in the East China Sea is described and illustrated by light and scanning electron microscopy. The new species can be easily distinguished from its congeners by the ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-3095-3
更新日期：2012-12-01 00:00:00
abstract：:Interferon-tau (IFN-tau) treatment of Trichinella spiralis-infected BALB/c mice was investigated. The therapeutic regimen consisted of daily intraperitoneal injection of 10(4) U murine IFN-tau for 7 days, starting at 2 weeks post-infection. Striated muscle samples (diaphragm, thigh) were collected at 4, 8 and 12 weeks...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00931641
更新日期：1991-01-01 00:00:00
abstract：:Twenty-five isolates of Echinococcus granulosus protoscoleces from hydatid cysts were collected from 25 buffaloes in five different provinces of Iran. DNA was extracted from protoscoleces and used for phylogenetical analysis. For this aim, the DNA was amplified using specific primers derived from cox1 gene and, subseq...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-2170-x
更新日期：2011-05-01 00:00:00
abstract：:To contribute to the knowledge of the role of small mammals in the transmission cycle of tegumentary leishmaniasis caused by Leishmania braziliensis, we studied the small mammal community and its temporal and spatial association with phlebotominae, as well as small mammal infection by Leishmania spp. by PCR-RFLP analy...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-017-5714-5
更新日期：2018-02-01 00:00:00
abstract：:For the identification of host species of blood-sucking parasites, the suitability of disc-electrophoresis of the stomach contents was tested. Mammalian blood in the stomach of the medicinal blood leech Hirudo medicinalis gave satisfactory results. In the case of mixed blood samples from H. medicinalis, the identifica...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00931901
更新日期：1993-01-01 00:00:00
abstract：:Thirty-two organic and aqueous extracts, belonging to 12 Argentine medicinal plants were tested for their in vitro trypanocidal activity on epimastigote forms of Trypanosoma cruzi. Among the selected species, the organic extracts of Ambrosia scabra, Ambrosia tenuifolia, Baccharis spicata, Eupatorium buniifolium, Lippi...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-005-0060-4
更新日期：2006-03-01 00:00:00
abstract：:Some cyclophyllidean cestodes provide protection for their eggs in the external environment by providing them with additional protective layers around the egg membranes. In attempting to examine such adaptations, the microanatomy and fine structure of the uterus of pregravid and gravid proglottids of the cyclophyllide...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-016-4997-2
更新日期：2016-06-01 00:00:00
abstract：:Prevalence and intensity of gastrointestinal parasites were studied through a longitudinal survey in 400 horses over a 17-month period in an abattoir in Germany. Three hundred and ten horses (77.5 %) were demonstrated harbouring endoparasites either by direct recovery of parasites from the digestive tract and/or in te...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-3150-0
更新日期：2013-01-01 00:00:00
abstract：:The present study evaluated the distribution and viability of Toxoplasma gondii tissue cysts in the organs and Brazilian commercial cuts of experimentally infected pigs. The pigs were infected with 3 × 103 oocysts of the T. gondii isolate TgCkBr57 (Type BrII). Mouse bioassays were performed on the brain, retina, tongu...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-019-06229-6
更新日期：2019-04-01 00:00:00
abstract：:An epidemiological and molecular survey was conducted to investigate the role of cattle in the transmission chain of cystic echinococcosis (CE) in the Campania region of southern Italy. Out of a total of 434 cattle examined for CE, 45 (10.4%) were found infected. A total of 363 cysts were collected from the infected a...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-008-0948-x
更新日期：2008-06-01 00:00:00
abstract：:CD4(+) T-helper (Th) cell is widely recognized to be capable of influencing worm development and egg granuloma formation after schistosome infection. Interleukin (IL)-12 and IL-4 play key roles in regulation of Th cell differentiation. In the present study, we subcutaneously inoculated mice with hybridoma cells secret...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-011-2487-0
更新日期：2012-01-01 00:00:00
abstract：:To quantify the effect of Nosema algerae (Microsporidia, Nosematidae) on the development of Plasmodium falciparum in Anopheles stephensi (Diptera, Culicidae), we carried out infection experiments under standardized laboratory conditions. Apart from a mean reduction of 69% in oocyst development, smaller numbers of oocy...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00931661
更新日期：1992-01-01 00:00:00
abstract：:The C57BL/6J strain of Mus musculus is susceptible to the terrestrial trematode Brachylaima cribbi. The duration of infection in these mice is generally 9-12 weeks with a peak excretion of eggs at 4 weeks post-infection (wpi). The effects of age and sex on the course of infection were investigated by comparing infecti...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-002-0642-3
更新日期：2002-07-01 00:00:00
abstract：:The fine structure of the infective hexacanths of Echinococcus multilocularis was examined with particular emphasis on the functional ultrastructure of penetration glands and nerve cells directly involved in the mechanism of initial host infection. The oncosphere contains two types of penetration glands, PG1 and PG2, ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-018-5957-9
更新日期：2018-08-01 00:00:00
abstract：:Leishmania spp. and Trypanosoma cruzi are parasites belonging to the Trypanosomatidae family and the causative agents for two very important neglected tropical diseases (NTDs), namely leishmaniasis and trypanosomiasis, respectively. Together, they affect millions of people worldwide and the number of cases is constant...
journal_title：Parasitology research
pub_type： 杂志文章,评审
doi：10.1007/s00436-020-07035-1
更新日期：2021-01-06 00:00:00
abstract：:Aelurostrongylus abstrusus (Nematoda, Metastrongyloidea) causes verminous pneumonia in cats worldwide. This study evaluated the seroprevalence of A. abstrusus antibodies in 220 stray and free-roaming cats from insular (Mykonos, Crete, Skopelos) and continental (Thessaloniki, Attica) Greece. The results were compared w...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-020-06839-5
更新日期：2020-09-01 00:00:00
abstract：:In an experiment including 8 groups of 15 mice, the effect of migrating Ascaris suum larvae in the lungs on the establishment and pathogenicity of aerosol exposure to Pasteurella multocida was investigated. Following aerosol exposure to P. multocida, mice with migrating A. suum in their lungs developed more severe pne...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00931575
更新日期：1992-01-01 00:00:00
abstract：:Nematodes and coccidia are major pathogens causing parasitic infections in livestock production. This study aimed to determine the prevalence and seasonality of gastrointestinal helminths and coccidia in communal sheep grazing in humid, semi-humid and arid zones of the Eastern Cape Province. A total of 3299 faecal sam...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-020-06927-6
更新日期：2020-12-01 00:00:00
abstract：:Ixodes holocyclus has a narrow, discontinuous distribution along the east coast of Australia. We studied ticks from 17 localities throughout the geographic range of this tick. The ITS2 of I. holocyclus is 793 bp long. We found nucleotide variation at eight of the 588 nucleotide positions (1.4%) that were compared for ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-001-0533-z
更新日期：2002-03-01 00:00:00
abstract：:The diagnosis of toxoplasmosis is often complicated by the lack of specific clinical symptoms or postmortem features, in humans and other animals. The only diagnostic test described so far for the serological diagnosis of Toxoplasma gondii in marine mammals is the modified agglutination test (Dubey et al., Am J Vet Re...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3674-y
更新日期：2014-02-01 00:00:00
abstract：:The invasive fish tapeworm, Khawia japonensis (Yamaguti, 1934) originally described in Japan, is reported for the first time in Slovakia. The tapeworm was found in farmed common carp (Cyprinus carpio L.) from East-Slovakian breeding fish pond. This finding is registered 4 years after the first announcement of this par...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-015-4447-6
更新日期：2015-05-01 00:00:00
abstract：:The effects of trypsin, bile, trypsin-bile, pepsin, dithiothreitol (DTT) and metacercarial excretory-secretory product (ESP) on the in vitro excystment of Clonorchis sinensis metacercariae were investigated. The majority of metacercariae excysted immediately in trypsin-bile in PBS solution, a process which was complet...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-004-1097-5
更新日期：2004-05-01 00:00:00
abstract：:There are first data on nematodes of Anas platyrhynchos Linnaeus, 1758 (mallard) and Bucephala clangula Linnaeus, 1758 (common goldeneye) from Northern Europe (Ladoga Lake region). The ducks were found to be infected with nine nematode species. A. platyrhynchos hosted eight nematode species and B. clangula was host to...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-015-4697-3
更新日期：2015-10-01 00:00:00
abstract：:In many helminthic infections, eotaxin, a CC-chemokine, triggers the mobilization of eosinophils, thus, contributing to an elevated blood and periparasitic eosinophil level. Following an experimental intraperitoneal infection of C57BL6 mice with Echinococcus multilocularis metacestodes, however, we observed the absenc...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-009-1549-z
更新日期：2009-10-01 00:00:00
abstract：:Angiostrongylus costaricensis can infect several mollusks, and its migration route in intermediate hosts has been studied only in Sarasinula marginata. To verify the susceptibility of Omalonyx sp. as an intermediate host of A. costaricensis and to analyze the nematode migration route, individuals were infected with st...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-008-1138-6
更新日期：2008-11-01 00:00:00
abstract：:In an effort to identify novel therapeutic alternatives for the treatment of malaria, the present study evaluated the antimalarial effect of the crude hydroalcoholic extract (HCE) from the leaves of Chenopodium ambrosioides L. For this purpose, the molecular affinity between the total proteins from erythrocytes infect...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-016-5216-x
更新日期：2016-11-01 00:00:00
abstract：:Efficacy and safety of treatment with imidacloprid 10%+moxidectin 2.5% spot-on (Advocate, Advantage multi; Bayer AG, Leverkusen, Germany) were tested in dogs naturally infested with Sarcoptes scabiei or Otodectes cynotis in a multi-centre, controlled, randomized, blinded field study conducted in France, Germany, Alban...
journal_title：Parasitology research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00436-005-1449-9
更新日期：2005-10-01 00:00:00
abstract：:Helminths are one of the major health problems of working donkeys, often with heavy worm burden and contributing to their early demise and/or reduction in their work output. Cross-sectional and longitudinal studies were conducted to investigate the current infection prevalence and level of strongyles infection donkeys...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-017-5485-z
更新日期：2017-07-01 00:00:00
abstract：:Gastrointestinal nematode (GIN) infections are a common constraint to small ruminant industry throughout the world, and among those, haemonchosis has its own significance. Control of GIN primarily relies on the use of anthelmintics, but this approach has become less reliable due to the development of resistance in GIN...
journal_title：Parasitology research
pub_type： 杂志文章,评审
doi：10.1007/s00436-011-2576-0
更新日期：2011-12-01 00:00:00
abstract：:Trypanosoma cruzi and Trypanosoma rangeli are kinetoplastid parasites which are able to infect humans in Central and South America. Misdiagnosis between these trypanosomes can be avoided by targeting barcoding sequences or genes of each organism. This work aims to analyze the feasibility of using species-specific mark...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-014-3872-2
更新日期：2014-06-01 00:00:00
