Abstract：
:Infections of Eimeria tenella in chicken embryos were used to compare the anticoccidial activity of ten drugs. The minimal inhibitory concentration (MIC) and minimal toxic concentration (MTC) were affected by the time of inoculation into the embryos and by the chemical nature of the compounds. Some compounds (nicarbazin, amprolium) had no effect on the development of coccidia when they were injected into embryos after the day of infection. Drugs that act early in the life cycle of coccidia (robenidine, clopidol, decoquinate, diclazuril, halofuginone, monensin, salinomycin, and lasalocid) were active at 5-125 micrograms/embryo when they were injected on the day of infection. The ionophores and halofuginone were highly toxic to embryos; most synthetic compounds were nontoxic. The incubation of merozoites in drug suspensions prior to the infection of embryos did not result in embryo toxicity, but the resultant MICs were much higher than those obtained when drugs were injected directly into the embryos. Several products were essentially inactive. Neither nicarbazin nor amprolium prevented oocyst formation. The widely divergent endpoints for the MIC and MTC of anticoccidials in embryos seriously limits the application of this technique as a screen for anticoccidial drugs.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Xie MQ,Fukata T,Gilbert JM,McDougald LRdoi
10.1007/BF00931020subject
Has Abstractpub_date
1991-01-01 00:00:00pages
595-9issue
7eissn
0932-0113issn
1432-1955journal_volume
77pub_type
杂志文章abstract：:Some cyclophyllidean cestodes provide protection for their eggs in the external environment by providing them with additional protective layers around the egg membranes. In attempting to examine such adaptations, the microanatomy and fine structure of the uterus of pregravid and gravid proglottids of the cyclophyllide...
journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究
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更新日期：2019-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-07-01 00:00:00
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更新日期：2014-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2018-12-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00933778
更新日期：1994-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00931082
更新日期：1990-01-01 00:00:00
abstract：:The ethanolic leaf extract of Cassia obtusifolia was investigated for their larvicidal and oviposition deterrence effects against Anopheles stephensi. Concentrations ranging from 25 to 125 mg/l were assessed at 24 h post-treatment against late third instar larvae. The leaf extract had significant larvicidal effect wit...
journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
