Sarcocystis neurona reacting antibodies in Missouri feral domestic cats (Felis domesticus) and their role as an intermediate host.

Abstract:

:Sarcocystis neurona is the parasite associated with equine protozoal myeloencephalitis (EPM). Recently, cats (Felis domesticus) have been implicated as a potential intermediate host in the life cycle of S. neurona. This study was initiated to determine whether cats have antibodies that react to S. neurona antigens similar to antibodies from horses with EPM, and to evaluate the role of cats as intermediate hosts in the parasite's life cycle. Nine feral cats were used for analysis. Only one had antibodies reacting to S. neurona antigens. Muscle tissue from this cat, with detectable sarcocysts in the tongue, was fed to an opossum (Didelphis virginiana). The opossum shed sporocysts, which were then fed to gamma-interferon receptor knockout mice. Histopathology, immunohistochemistry, parasite isolation and molecular analysis were used to examine the pathology and associated parasites in the mice. The study suggests that the domestic cat can serve as an intermediate host to S. neurona or a S. neurona-like organsim.

journal_name

Parasitol Res

journal_title

Parasitology research

authors

Turay HO,Barr BC,Caldwell A,Branson KR,Cockrell MK,Marsh AE

doi

10.1007/s004360100503

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

38-43

issue

1

eissn

0932-0113

issn

1432-1955

journal_volume

88

pub_type

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