Abstract：
:A key challenge in the successful treatment of Acanthamoeba infections is its ability to transform into a dormant cyst form that is resistant to physiological conditions and pharmacological therapies, resulting in recurrent infections. The carbohydrate linkage analysis of cyst walls of Acanthamoeba castellanii showed variously linked sugar residues, including xylofuranose/xylopyranose, glucopyranose, mannopyranose, and galactopyranose. Here, it is shown that exogenous xylose significantly reduced A. castellanii differentiation in encystation assays (P < 0.05 using paired t test, one-tailed distribution). Using small interfering RNA (siRNA) probes against xylose isomerase and cellulose synthase, as well as specific inhibitors, the findings revealed that xylose isomerase and cellulose synthase activities are crucial in the differentiation of A. castellanii. Inhibition of both enzymes using siRNA against xylose isomerase and cellulose synthase but not scrambled siRNA attenuated A. castellanii metamorphosis, as demonstrated by the arrest of encystation of A. castellanii. Neither inhibitor nor siRNA probes had any effect on the viability and extracellular proteolytic activities of A. castellanii.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Aqeel Y,Siddiqui R,Khan NAdoi
10.1007/s00436-012-3254-6subject
Has Abstractpub_date
2013-03-01 00:00:00pages
1221-7issue
3eissn
0932-0113issn
1432-1955journal_volume
112pub_type
杂志文章abstract：:A new neogregarine pathogen of the great spruce bark beetle, Dendroctonus micans (Coleoptera: Curculionidae, Scolytinae), is described based on light microscopy and ultrastructural characteristics. The pathogen infects the fat body and the hemolymph of the beetle. The infection was nonsynchronous so that different dev...
journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-002-0623-6
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-003-1022-3
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pub_type： 杂志文章
doi：10.1007/s00436-012-3181-6
更新日期：2013-02-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章,评审
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更新日期：2010-02-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
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更新日期：2011-03-01 00:00:00
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pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2012-02-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00931698
更新日期：1992-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050579
更新日期：1999-06-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-021-07056-4
更新日期：2021-01-22 00:00:00
abstract：:The authors recognized a mistake in Abstract and in the Discussion section. ...
journal_title：Parasitology research
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00436-018-5884-9
更新日期：2018-06-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3487-z
更新日期：2013-09-01 00:00:00
