Abstract：
:In vitro leucocyte proliferative responses to parasite antigens and to mitogens as well as lymphocyte sub-types were compared in guinea pigs with genetically determined differences in their ability to express protective immunity against Trichostronylus colubriformis infection. Proliferative responses to parasite antigens were greatest in high-responder (HR) animals, but cells from low-responder (LR) animals were generally more responsive to mitogens. However, HR circulating leucocytes were more responsive to the T-cell-dependent B-cell mitogen pokeweed mitogen (PWM), and the response of HR, but not LR, cells increased during primary infection with T. colubriformis. Flow cytometry revealed significantly greater numbers of circulating B-cells in HR animals and, as observed for responsiveness to PWM, the number of circulating B-cells increased in HR, but not LR, animals during primary infection with this parasite. These findings suggest a larger and more labile population of B-cells in HR guinea pigs.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Manjili MH,Sangster NC,Rothwell TLdoi
10.1007/s004360050048subject
Has Abstractpub_date
2000-04-01 00:00:00pages
311-7issue
4eissn
0932-0113issn
1432-1955journal_volume
86pub_type
杂志文章abstract：:Cystic echinococcosis is a worldwide zoonosis caused by Echinococcus granulosus. Because the methods of diagnosis and treatment for cystic echinococcosis were limited, it is still necessary to screen target proteins for the development of new anti-hydatidosis vaccine. In this study, the triosephosphate isomerase gene ...
journal_title：Parasitology research
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更新日期：2003-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-05-01 00:00:00
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journal_title：Parasitology research
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更新日期：2001-12-01 00:00:00
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journal_title：Parasitology research
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更新日期：2008-03-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2012-03-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2009-09-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050096
更新日期：1996-01-01 00:00:00
