Abstract：
:Haematophagous leeches express a broad variety of bioactive factors that are released from the salivary gland cells into the wound of a host during feeding. Among these, hirudin is probably the best studied factor and, moreover, the only one that has successfully made the transition from nature to clinical use. Many components of the leech saliva still remain either poorly characterized or yet completely unknown. Only recently, a new class of leech-derived factors has been discovered in Hirudo medicinalis, the hirudin-like factors (HLFs). HLFs comprise typical structural features of hirudin but lack others. We were able to verify the expression of HLFs not only in two additional species of the genus Hirudo, but also in Hirudinaria manillensis. Various phylogenetic analyses based on gene and protein sequences support a sister group relationship between hirudins and HLFs. Although potential molecular targets of HLFs remain unknown, the presence of multiple isoforms in individual leeches of different genera points to key functions in the regulation of several processes associated with the blood-sucking life style of leeches.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Müller C,Haase M,Lemke S,Hildebrandt JPdoi
10.1007/s00436-016-5294-9subject
Has Abstractpub_date
2017-01-01 00:00:00pages
313-325issue
1eissn
0932-0113issn
1432-1955pii
10.1007/s00436-016-5294-9journal_volume
116pub_type
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