Abstract:
:The DNA from PBMCs of both hepatitis C virus (HCV)-positive patients and healthy HCV-negative human individuals tested thus far contains essential parts--up to 272/341 nucleotides--of the HCV 5'-non-coding region (5'-NCR). These findings bring up the question of the possible evolutionary background of these sequences. Therefore, using the same methodology, we looked for the same sequences in animals closely related to man, i.e., in nonhuman primates (two chimpanzees, one orang-utan, one Debrazza monkey, two New World monkey species and a prosimian). The DNA from PBMCs of the studied animals belonging to nonhuman primates contains essential parts--up to 272/341 nucleotides--of the HCV 5'-non-coding region (5'-NCR). A common sequence of 82 nucleotides is contained in the DNA of all the tested animals but only the chimpanzee's DNA harbors the same, longer sequence region of 272/341 nucleotides of the 5'-NCR found in human DNA. The results may provide a clue as to the possible origin of parts of the IRES containing sequence area of the HCV.
journal_name
Z Gastroenteroljournal_title
Zeitschrift fur Gastroenterologieauthors
Dennin RH,Wo J,Chen Z,Roos Cdoi
10.1055/s-2000-10021subject
Has Abstractpub_date
2000-12-01 00:00:00pages
925-31issue
12eissn
0044-2771issn
1439-7803journal_volume
38pub_type
杂志文章abstract::Pseudomembranous colitis is a well known complication of antibiotic therapy. Only recently few cases of another form of an antibiotic-associated colitis, the acute segmental haemorrhagic penicillin-associated colitis, have been described. We report another case and point out the importance of early colonoscopy to dist...
journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
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更新日期:1992-04-01 00:00:00
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journal_title:Zeitschrift fur Gastroenterologie
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章,评审
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journal_title:Zeitschrift fur Gastroenterologie
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章,评审
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更新日期:1999-06-01 00:00:00
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章,评审
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
doi:
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
doi:
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journal_title:Zeitschrift fur Gastroenterologie
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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