[CMV-associated enterocolitis due to primary CMV infection in the immunocompetent].

Abstract:

:Cytomegalovirus (CMV) plays an important role in non-immunocompetent patients due to its high seroprevalence and life-long persistence. However, cases of severe CMV infections are also described in the immunocompetent. Here in particular, the gastrointestinal involvement is of major importance. We describe the case of a 29-year-old immunocompetent young man, who presented with a primary CMV infection mainly of the colon with clinical signs of bloody diarrhoea, fever, hepatitis and haemolysis. The diagnosis was established on the basis of a suspicious endoscopic finding with immunohistochemical detection of CMV in the colonic mucosa, a positive CMV viral load in the peripheral blood and an immune system response typical for primary infection. Based on this case and previous publications, we suggest that a colonoscopy and diagnostic procedures for CMV should be considered if the patient presents with gastrointestinal symptoms like (bloody) diarrhoea, fever, and hepatitis. In a severe case, we recommend antiviral therapy due to a high mortality that has been reported for CMV colitis in immunocompetent individuals.

journal_name

Z Gastroenterol

authors

Spinner CD,Vogelmann R,Hoffmann D,Nährig J,Schmid RM,von Delius S

doi

10.1055/s-0031-1273487

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1259-63

issue

11

eissn

0044-2771

issn

1439-7803

journal_volume

51

pub_type

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