Abstract：
:Because of the central importance of the liver for the metabolism of estrogens and androgens the chronically ill liver per se represents an essential disturbing factor within the hypothalamic-pituitary-gonadal axis caused by the altered hepatic metabolism of the steroid hormones as well as the abnormal synthesis of steroid-hormone-binding proteins with changed free fractions of sex hormones. The question has been differently answered whether a chronic hepatic disease can also be the reason for disturbance on hypothalamic-pituitary and/or testicular level. Recent plasma determination of LH/FSH before and after LHRH and clomiphene, of sex hormones before and after HCG as well as unbound sex hormones in males with chronic hepatic diseases lead to the following conclusion. 1. Chronic liver disease (without idopathic hemochromatosis). Even sever chronic hepatic diseases are not accompanied by primary hypopituitarism. With regard to the impaired Leydig cells stimulation by HCG and the abnormal seminal fluid and testicular histology one can suppose a primary gonadal hypogonadism. However, an additional hypothalamic disturbance has to be considered. 2. Idiopathic hemochromatosis. Presumably in hemochromatosis a primary insufficiency of pituitary and/or testes can take place related to the general metabolic disturbances of this illness. The classic hypothesis of an exclusively primary lesion with secondary hypogonadism does not appear to be correct.
journal_name
Z Gastroenteroljournal_title
Zeitschrift fur Gastroenterologieauthors
Geisthövel Wsubject
Has Abstractpub_date
1979-07-01 00:00:00pages
422-38issue
7eissn
0044-2771issn
1439-7803journal_volume
17pub_type
杂志文章,评审abstract：:Modern metabolic research in hepatology employs non-invasive techniques of the whole organism, and it includes studying the intact organ. Following recent decades of efforts in culturing isolated cells and studying their properties separately, it has become clear that the spatiotemporal organisation of different cell ...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章,评审
doi：10.1055/s-0031-1273392
更新日期：2011-06-01 00:00:00
abstract：:The present paper, based on the current literature, considers the practical aspects of bile acid radioimmunoassays. The problems associated with the raising of specific antisera and their characterization are discussed. Features of assay design for bile acids are considered. Solid-phase radioimmunoassays are described...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1978-03-01 00:00:00
abstract：:The primary aim of the Prä-GIT study is to collect information on the prevalence and course of precancerous and early malignant lesions in the upper GIT (uGIT) as well as risk factors associated with these lesions in asymptomatic individuals. Study participants presenting for a screening colonoscopy will undergo an ad...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/a-1190-5332
更新日期：2020-08-01 00:00:00
abstract：:The existence of tight junctions between epithelial cells has been known for over 100 years, but their exact functions remained elusive until recently. The present paper summarizes the newest knowledge about morphology, molecular components and regulation of tight junctions. In the chapter about morphology the criteri...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章,评审
doi：
更新日期：1997-03-01 00:00:00
abstract：:We report on the case of a segmentally emphasised, ulcerous chronic haemorrhagic colitis with the development of granulation tissue und scarred fibrosis with consecutive resulting stenosis of the colon. A 49-year-old male patient was infected with enterohaemorrhagic Escherichia coli bacteria during the EHEC-epidemic i...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-0031-1299059
更新日期：2012-05-01 00:00:00
abstract：:Background and aims Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Infection with the hepatitis C virus (HCV) is one of the most frequent underlying diseases leading to HCC development. Sorafenib is the standard of care for HCC patients not amenable to local treatment, r...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-0042-118232
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:In general, the rare SPT is a tumour of low malignancy predominantly affecting young women. The outcome after radical resection is favourable. In exceptional cases the tumour presents as solid pseudopapillary carcinoma (SPC) with typical malignant features and even metastases. Unresectable liver metastases c...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-2008-1027318
更新日期：2008-07-01 00:00:00
abstract：:An HIV-1 seronegative man presented with odynophagia, dysphagia, diarrhea, tenesmus and a 50-lb weight loss. A large esophageal ulcer and a rectal fissure were identified endoscopically. Stool samples and biopsy specimens from the esophageal ulcer, duodenum, colon and rectum were negative for pathogens. Seronegative A...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-2007-963051
更新日期：2007-08-01 00:00:00
abstract：:The growing data about new endoscopic therapies for gastroesophageal reflux disease (GERD) seem to indicate that these techniques might be effective at least in a part of patients suffering from GERD. However, up to now it is not clear which technique is the best. Randomized studies comparing the different techniques ...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章,评审
doi：10.1055/s-2003-41824
更新日期：2003-09-01 00:00:00
abstract：:In this prospective study, we compared the assessment of gastric emptying by the 13C-octanoic acid breath test to gastric emptying scintigraphy in diabetics. We also examined the relationship between gastric emptying parameters and gastric symptoms and cardiovascular autonomic function. The 13C-octanoic acid breath te...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 临床试验,杂志文章
doi：10.1055/s-2003-39331
更新日期：2003-05-01 00:00:00
abstract：:We have applied the ion sensitive analysis of hydrogen (H2) in expired air in intervals of five minutes for five hours to determine carbohydrate malabsorption. In 19 patients with lactose malabsorption the increase in hydrogen was prior (45, SE 13 min) to healthy volunteers (142, SD 71 min, p less than 0.01). In compa...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1983-11-01 00:00:00
abstract：:The intercellular adhesion molecule 1 (ICAM-1, CD54) and the lymphocyte associated antigen 3 (LFA-3, CD58) have been found in soluble form (sCD54 and sCD58) in human sera. Data concerning their role in chronic liver disease and their usefulness in disease monitoring are contradictory. We addressed the question whether...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：:Nonalcoholic steatohepatitis describes a hepatic disorder with the typical characteristics of an alcoholic pathogenesis without alcohol consumption. It was first described in 1962 and named NASH by Ludwig et al. 1980. Many researchers worked on this disease since this time. It represents the hepatic manifestation of t...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章,评审
doi：10.1055/s-2003-36679
更新日期：2003-01-01 00:00:00
abstract：:A 61-year-old white female with chronic hepatitis C virus (HCV) infection first diagnosed in 1994 was admitted with two newly discovered lesions in the liver suspected to represent hepatocellular carcinoma. The alpha-1-fetoprotein (AFP) level was within normal limits and there was neither clinical nor sonographic evid...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：BACKGROUND:The introduction of the S3 guideline on "Sedation in Gastrointestinal Endoscopy" in 2008 led to substantial organisational, structural, staffing-related, financial, and legal changes in the everyday work of departments of gastrointestinal endoscopy. This study examines the economic effects of this and the ch...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-0032-1313080
更新日期：2012-09-01 00:00:00
abstract：:On the basis of 3 of our own cases, we describe unusually intense forms of filiform polyposis and local giant polyposis as a consequence of chronic inflammatory bowel disease. The patients are: A 52-year-old woman who for 7 years has been known to have Crohn's disease (CD); a 55-year-old man who for 14 years has been ...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章,评审
doi：10.1055/s-2000-9994
更新日期：2000-10-01 00:00:00
abstract：:Gallstone disease is more common in the elderly. In this short review, we summarize guideline-based recommendations for the diagnosis and treatment of biliary diseases in elderly patients. Warning episodes of biliary colic represent a general indication for cholecystectomy to avoid stone-related complications. Elderly...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章,评审
doi：10.1055/s-0034-1366158
更新日期：2014-05-01 00:00:00
abstract：:A retrospective analysis was performed in 332 cases with cancer of the upper gastrointestinal tract. A limit of one month was set for delayed and missed bioptically verified endoscopic diagnosis. Malignant cycle in ulcerated lesions and the size of elevated processes were the probable causes of delayed diagnosis in 7 ...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1978-04-01 00:00:00
abstract：:Potential therapeutic benefits of dietary n-3 fatty acids are presently evaluated in arteriosclerotic and chronic inflammatory diseases. Because some other long-chain fatty acids inhibit intestinal fluid absorption, the effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on fluid and electrolyte tran...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:Introduction and aims High-resolution esophageal manometry (HRM) has improved the diagnostic work-up of esophageal motility disorders. Simultaneous evaluation of bolus clearance delivers useful information about the function of tubular esophagus. We assessed bolus clearance in a combined HRM-impedance examination for ...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-0042-121267
更新日期：2017-02-01 00:00:00
abstract：:The recent discussions about the relationship between helicobacter-pylori-infection, gastritis and the occurrence of stomach cancer caused us to analyse blood sera of 543 participants randomly selected from the general population in the age of 25 to 34 and of 55 to 64 years from Mosbach (Neckar-Odenwald-Kreis), the co...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：BACKGROUND AND AIM:Several gastrointestinal diseases are localised in the small bowel and are confirmed by duodenal biopsies upon upper gastrointestinal endoscopy. However, the clinical value of routine duodenal biopsies during endoscopy has not been satisfactorily defined and was assessed in the current study. METHOD...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-2008-1027407
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:With regard to quality of life and organ shortage, follow-up after liver transplantation (LT) should consider risk factors for allograft failure in order to avoid the need for re-LT and to improve the long-term outcome of recipients. Therefore, the aim of this study was to explore potential risk factors for ...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-0043-125225
更新日期：2018-07-01 00:00:00
abstract：:For many years ultrasound-guided biopsy and drainage has represented a routine part of clinical practice. Percutaneous biopsy and drainage are minimally invasive procedures for sampling tissue or the removal of fluid collections within the body. Differing image guidance techniques for the positioning of the needles/ca...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章,评审
doi：10.1055/s-0029-1245706
更新日期：2010-11-01 00:00:00
abstract：:Squamous cell carcinomas account for more than 80 % of esophageal malignancies in Germany. Alcohol and tobacco smoke are two of the most important risk factors. In superficial esophageal squamous cell carcinoma, endoscopic mucosal resection (EMR) is a very useful and effective treatment modality. However, in patients ...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-2004-813221
更新日期：2004-07-01 00:00:00
abstract：:Acoustic radiation force Impulse (ARFI) technology correlates shear-wave velocity with fibrosis. It can differentiate between advanced fibrosis and normal tissue in chronic liver disease. However, specificity is impaired by cholestasis, inflammation or oedema in acute hepatitis. In patients with acute liver failure (A...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-0029-1245690
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Cystic liver lesions include hepatic echinococcosis as an important differential diagnosis, especially in patients from endemic countries. Serology might be false negative in a relevant percentage of the patients. Thus, modern clinical imaging techniques are the most important non-invasive means for making o...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-2008-1027295
更新日期：2008-10-01 00:00:00
abstract：:Iatrogenic perforation of the upper gastrointestinal tract is one of the most serious complications of upper gastrointestinal endoscopy, with high rates of morbidity and mortality. Treatment is challenging because stent placement or surgical repair of the perforation in this area is often impossible. We report on two ...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-0033-1356441
更新日期：2014-03-01 00:00:00
abstract：:Localization of gastroenteropancreatic neuroendocrine tumors with conventional imaging techniques can be difficult. With the advent of the somatostatin-receptor scintigraphy the diagnosis of these could be improved. In this study 76 patients with immunohistologically proven neuroendocrine tumors were analysed by compa...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：:Diabetes and pancreatic cancer are known to be associated. The relative risk for pancreatic carcinoma is dependent on the time after onset of diabetes. Diabetes in patients with pancreatic carcinoma is frequently of recent onset and partially caused by the tumor. Diabetes in a patient without obesity, no family histor...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章,评审
doi：
更新日期：1999-06-01 00:00:00
