[Histological changes in liver tissue in cholestasis].

Abstract:

:Cholestasis is a combination of defined clinical, paraclinical and morphological findings of which icterus is the direct symptom. It is the consequence of the delay or detention of the bile flow. By means of light microscopy different changes can be observed in hepatic tissue: formation of biliary thrombi, intracellular deposition of biliary components, ductal cholestasis with dilatation of the bile-duct lumina and applanation of the bile-duct epithelium, ductular proliferates and furthermore inflammatory mesenchymal reactions with cholangiolitis and cholangitis. These changes strengthen in dependence on the intensity and duration of the existing cholestasis. Bile lakes, bile extravasates, and biliary infarctions may occur in the process. The differentiation between intrahepatic non-mechanically and (extra-)hepatic mechanically conditioned cholestasis is of clinical importance. In the former the production and secretion of bile is disturbed (hepatosis, hepatitis and others), in the latter the extrahepatic bile ducts are above all affected: the bile flow is disturbed by stenosis, compression and obturation. The differentiation between the two kinds of cholestasis is impossible in the first three weeks because both of them develop identical lesion patterns. Distinguishable changes occur only after that. Consequently, findings from liver biopsy can only be a statement of probability. Reliable differentiation between the two kinds of cholestasis is however possible by means of modern technical methods for diagnostic purposes.

journal_name

Z Gastroenterol

authors

Machnik G

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

7-10

eissn

0044-2771

issn

1439-7803

journal_volume

31 Suppl 2

pub_type

杂志文章
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    authors: Thies E,Lange V,Lühmann B

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    authors: Schmidt-Wilcke HA

    更新日期:1981-07-01 00:00:00

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    pub_type: 杂志文章

    doi:

    authors: Seifert J,Ganser R,Brendel W

    更新日期:1979-01-01 00:00:00

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    更新日期:2002-07-01 00:00:00

  • [Intragastric utilization of antacids following meals in relation to stomach emptying].

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    doi:

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    更新日期:1983-03-01 00:00:00

  • NAT1 genotypes do not predict response to mesalamine in patients with ulcerative colitis.

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  • [Biologic therapy of inflammatory bowel disease].

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    pub_type: 杂志文章,评审

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    authors: Baumgart DC,Wiedenmann B,Dignass AU

    更新日期:2003-10-01 00:00:00

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    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

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    更新日期:1978-05-01 00:00:00

  • [Comparison of quantitative liver function tests to clinical, laboratory chemical and biopsy findings in patients with liver diseases].

    abstract::Quantitative liver function tests (QLFT), e.g. 1) galactose elimination capacity (GEK) and 2) fractional indocyanine-green elimination constant k (ICG) were performed in patients with various liver diseases. Retrospectively the results of QLFT were compared to clinical, histological and laboratory findings which are k...

    journal_title:Zeitschrift fur Gastroenterologie

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    更新日期:1988-02-01 00:00:00

  • Pharmacological treatment of hepatocellular carcinoma with cavoatrial tumor thrombus - case series and literature review.

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    pub_type: 杂志文章,评审

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    更新日期:2013-11-01 00:00:00

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    更新日期:2009-05-01 00:00:00

  • Colonoscopy use in a country with a long-standing colorectal cancer screening programme: evidence from a large German survey.

    abstract:BACKGROUND:Given the potential colonoscopy has in prevention and early detection of colorectal cancer (CRC), its overall use within a population is a meaningful parameter to estimate the future CRC burden. We aimed to examine overall prevalence and correlates of colonoscopy use in Germany, a country with a long-standin...

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    更新日期:2010-12-01 00:00:00

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    abstract::Fluorouracil-associated cardiotoxic adverse events represent a relevant but underestimated problem in 5-fluorouracil treatment. After right hemicolectomy for adenocarcinoma of the rightsided colonic flexure a 59-year old patient was referred to our hospital for adjuvant chemotherapy according to MOSAIC-protocol with o...

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    更新日期:2006-09-01 00:00:00

  • [Long-term collagenous sprue--remission with a gluten-free diet].

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    doi:

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    更新日期:1999-12-01 00:00:00

  • [Screening gastroscopy in Germany - first results of the pilot phase of the Prä-GIT study].

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  • [Segmental necrotizing colitis in a patient with E. coli O104:H4 infection].

    abstract::A 29-year-old man presented with abdominal cramps and bloody diarrhoea. Blood tests revealed elevated C-reactive protein (21.3 mg/dL; normal range 0.01 - 0. 82 mg/dL) and white blood cells (28200/μL, normal range 4000 - 10000/μL). Stool tests were negative for enteropathogenic bacteria and Clostridium difficile toxins...

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    pub_type: 杂志文章

    doi:

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    更新日期:1985-05-01 00:00:00

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    更新日期:2000-02-01 00:00:00

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    doi:

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    更新日期:1982-07-01 00:00:00

  • [Determination of surgical status: stomach cancer].

    abstract::In spite of a decrease in the frequency of gastric carcinoma as shown in some statistics this malignoma still is an almost daily challenge in surgery. The prognosis of the gastric cancer, in general, depends upon the time of onset of therapy and the tumor grading. At present, chemotherapy and radiation therapy cannot ...

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    doi:

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    更新日期:1985-03-01 00:00:00

  • [Routine use of a computer-assisted documentation system for esophago-gastro-duodenoscopy].

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    doi:

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    更新日期:1991-03-01 00:00:00

  • [Gastroenterology in the former GDR (1975-1990) and the changes after German reunification].

    abstract::This short overview sketches the state of Gastroenterology in the GDR (1975 - 1990) from the point of view of an East-German contemporary witness. The "Society for Gastroenterology/GDR" (GfG) has played a decisive role for the development of the Gastroenterology in the GDR. The society promoted medical education and c...

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  • [The acid pocket - a novel target for the treatment of gastro-esophageal reflux disease].

    abstract::Increased acid reflux after meals is a key feature of gastro-esophageal reflux disease (GERD) and is the most important cause for patient symptoms, particularly heartburn and acid regurgitation. Chronic acid exposure also predisposes to associated pathologies including reflux esophagitis, esophageal stricture, Barrett...

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    更新日期:2018-10-01 00:00:00

  • [Gastrointestinal hormones and blood circulation in the gastric mucosa].

    abstract::The gastrointestinal hormones influence gastric mucosal blood flow in different ways. Gastrin, secretin and pancreocymin increase gastric mucosal blood flow, glucagon, vip and somatostatin decrease it. Motilin has a special position. Given alone motilin improves gastric mucosal blood flow, wheras it reduces gastric mu...

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    更新日期:1976-03-01 00:00:00

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    更新日期:1995-01-01 00:00:00