Celiac disease screening among healthy blood donors in Hungary.

Abstract:

BACKGROUND:Celiac disease (CD) is a common chronic systemic autoimmune disease in Europe. The prevalence of CD in Hungarian children is estimated at 1.2 - 1.4 %. To date, however, no data on adult CD prevalence has been published. AIMS:Analysis of the serological evidence for CD among Hungarian adults in order to estimate its prevalence. METHODS:Plasma samples from 4155 healthy blood donors were anonymously screened for circulating IgA autoantibodies by a highly sensitive tissue transglutaminase ELISA. Positive results were subsequently confirmed by endomysial antibody test. RESULTS:Endomysial antibody test confirmed positivity in 25 samples suggesting a prevalence of CD of at least 0.6 % (1:166). Since no identification on the samples was provided, no further examinations could be done on endomysial antibody positive individuals. CONCLUSIONS:The first serological screening study among healthy Hungarian adult blood donors showed a prevalence of CD similar to other central European countries and lower than that in Hungarian children. Among countries worldwide, the Hungarian prevalence of CD appears to be in the mid-range, although pediatric data suggest a higher prevalence.

journal_name

Z Gastroenterol

authors

Sárdy M,Kornseé Z,Kelemen D,Papp S,Medvecz M,Kárpáti S

doi

10.1055/s-0033-1335450

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1235-9

issue

11

eissn

0044-2771

issn

1439-7803

journal_volume

51

pub_type

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