Abstract:
BACKGROUND:Celiac disease (CD) is a common chronic systemic autoimmune disease in Europe. The prevalence of CD in Hungarian children is estimated at 1.2 - 1.4 %. To date, however, no data on adult CD prevalence has been published. AIMS:Analysis of the serological evidence for CD among Hungarian adults in order to estimate its prevalence. METHODS:Plasma samples from 4155 healthy blood donors were anonymously screened for circulating IgA autoantibodies by a highly sensitive tissue transglutaminase ELISA. Positive results were subsequently confirmed by endomysial antibody test. RESULTS:Endomysial antibody test confirmed positivity in 25 samples suggesting a prevalence of CD of at least 0.6 % (1:166). Since no identification on the samples was provided, no further examinations could be done on endomysial antibody positive individuals. CONCLUSIONS:The first serological screening study among healthy Hungarian adult blood donors showed a prevalence of CD similar to other central European countries and lower than that in Hungarian children. Among countries worldwide, the Hungarian prevalence of CD appears to be in the mid-range, although pediatric data suggest a higher prevalence.
journal_name
Z Gastroenteroljournal_title
Zeitschrift fur Gastroenterologieauthors
Sárdy M,Kornseé Z,Kelemen D,Papp S,Medvecz M,Kárpáti Sdoi
10.1055/s-0033-1335450subject
Has Abstractpub_date
2013-11-01 00:00:00pages
1235-9issue
11eissn
0044-2771issn
1439-7803journal_volume
51pub_type
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journal_title:Zeitschrift fur Gastroenterologie
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pub_type: 临床试验,杂志文章
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journal_title:Zeitschrift fur Gastroenterologie
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