Abstract：
:Quantitative liver function tests (QLFT), e.g. 1) galactose elimination capacity (GEK) and 2) fractional indocyanine-green elimination constant k (ICG) were performed in patients with various liver diseases. Retrospectively the results of QLFT were compared to clinical, histological and laboratory findings which are known to reflect severity of liver disease. Patients showing clinical symptoms like ascites and/or encephalopathy demonstrated lower values for GEK and ICG. In addition similar data were obtained for those patients who showed histological evidence of cirrhosis. When dividing up the group of cirrhotics according to PUGH's classification, correspondingly lower results of QLFT were observed between different PUGH classes, however, due to a substantial overlap an individual classification could not be achieved by QLFT. Compared to routine laboratory tests which might estimate hepatic functional impairment the following correlations were found: GEK to albumin: r = 0.47, p < 0.01, to Quick: r = 0.44, p < 0.001, to bilirubin: r = -0.23, p < 0.05, ICG to albumin: r = 0.45, p < 0.01, to Quick: r = 0.53, p < 0.001, to bilirubin: r = -0.42, p < 0.001. No correlation could be demonstrated to transaminase activity. The results obtained support the view that QLFT are capable of estimating hepatic function, however, compared to conventional characteristics of advanced liver disease only moderate correlations were detected. A superiority of quantitative liver function tests could not be detected.
journal_name
Z Gastroenteroljournal_title
Zeitschrift fur Gastroenterologieauthors
Albers I,Hartmann H,Creutzfeldt Wsubject
Has Abstractpub_date
1988-02-01 00:00:00pages
130-6issue
2eissn
0044-2771issn
1439-7803journal_volume
26pub_type
杂志文章abstract：:Within the last few years intestinal metaplasia at the gastroesophageal junction (Barrett's esophagus) has turned out to be a "shooting star" in the field of gastrointestinal diseases. The detection rate of Barrett's epithelium by the endoscopists and pathologists has raised dramatically as well as the incidence of th...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
abstract：:Non-resectable cholangiocarcinoma and gallbladder carcinoma have a poor prognosis. In addition to the general aspects of "best supportive care", biliary drainage is an important part of the palliative treatment of patients with malignant biliary stenosis. Photodynamic therapy has led to an improved median survival in ...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章,评审
doi：10.1055/s-2006-926869
更新日期：2006-07-01 00:00:00
abstract：:The current recommendations on indications, technical performance, and interpretation of diagnostic techniques for oesophageal reflux update the German recommandations about 24 hour pH measurement of 2003. The recommendations encompass conventional pH measurement, wireless pH measurement, pH and impedance measurements...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-0032-1325483
更新日期：2012-12-01 00:00:00
abstract：:The efficacy of oxaliplatin combined with high-dose 5-fluorouracil (5-FU) and folinic acid (FA) as an outpatient salvage treatment for patients with metastasized colorectal cancer was retrospectively analyzed in one center. Tumor progression had occurred for the majority of patients during two regimens (n = 11) otherw...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-2000-14853
更新日期：2000-02-01 00:00:00
abstract：:The over the scope clip (OTSC) is mainly used for closure of gastrointestinal endoluminal defects and treatment of gastrointestinal bleeding. Its use for resection of subepithelial tumors or full-thickness resection is still under investigation. Duodenal neuroendocrine tumors (NET) are rare neoplasms. Endoscopic resec...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-0034-1398898
更新日期：2015-03-01 00:00:00
abstract：:Case-report of a 54 year-old patient who was admitted with the clinical picture of an acute abdomen on the basis of intraabdominal haemorrhage. X-ray investigation discounted the diagnosis of ruptured aortic aneurysm, the CAT scan showed a suspected acute haemorrhagic necrotising pancreatitis. At laparotomy, a fatty, ...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1982-05-01 00:00:00
abstract：BACKGROUND:5- Aminosalicylic acid (5-ASA) is metabolised in colonic mucosa by N-acetyltransferase 1 (NAT1). Common genetic polymorphisms in this enzyme result in rapid or slow acetylation. 5-ASA treatment causes side effects in up to 10 % of patients with ulcerative colitis (UC). We therefore determined genetic variati...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-2007-963673
更新日期：2008-03-01 00:00:00
abstract：:Alpha 1-antitrypsin (alpha 1 AT) is a glycoprotein of hepatic origin which functions as a systemic protease inhibitor (Pi). Its production is controlled by two autosomal-codominantly transmitted alleles. Among the numerous genetic variants some alleles (predominantly PiZ) may induce alpha 1 AT-deficiency, facultativel...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章,评审
doi：
更新日期：1982-07-01 00:00:00
abstract：:The absorption of the proteolytic enzyme bromelain was investigated in adult rats. Bromelain was labelled radioactively with 125-Iodine and intraduodenally applied. During the observation time of 6 hours blood- and lymphsamples were collected and their radioactivity measured. By radiochromatography high molecular prot...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:12% of the rectal biopsies (19% of the patients) showed epitheloid cell granulomas in clinically definite Crohn's disease. In colonic biopsies such granulomata were visible in 14% (22% of the patients). Granulomata were scarcely seen in normal or slightly inflamed mucosa. They were mostly found together with crypt abs...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
abstract：:The results of a cardiologic work-up in patients with retrosternal pain are negative in about 20-30% of cases. Overall one half of these patients exhibit an esophageal dysfunction. In order to diagnose esophageal dysfunction long-term pH-metry, transit scintigraphy and standard manometry are used as well as provocatio...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章,评审
doi：
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND: Verrucous carcinoma of the esophagus is a rare disease leading to dysphagia, chest pain, and weight loss. The diagnosis is difficult because even repeated biopsies are often without tumor evidence. We present a patient with verrucous carcinoma of the esophagus and a literature review. CASE REPORT: A 64-yea...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章,评审
doi：10.1055/a-1231-5820
更新日期：2020-10-01 00:00:00
abstract：:Endoscopic retrograde cholangiography (ERC) after Roux-en-Y reconstruction and modified BII surgery or duodenopancreatectomy is considerably more difficult than ERC under normal anatomic conditions. If the common bile in the afferent loop cannot be reached by a common lateral-viewing duodenoscope because of excessive ...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-2007-963783
更新日期：2008-04-01 00:00:00
abstract：:On the basis of 3 of our own cases, we describe unusually intense forms of filiform polyposis and local giant polyposis as a consequence of chronic inflammatory bowel disease. The patients are: A 52-year-old woman who for 7 years has been known to have Crohn's disease (CD); a 55-year-old man who for 14 years has been ...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章,评审
doi：10.1055/s-2000-9994
更新日期：2000-10-01 00:00:00
abstract：:We prospectively compared esophageal and rectal motility data from 7 patients with progressive systemic sclerosis (4 females, 3 males) to esophageal recordings in 22 and anorectal recordings in 9 healthy controls. All patients with sclerosis exhibited motility disturbances in the lower esophageal sphincter (LES): LES ...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1988-11-01 00:00:00
abstract：:Mild anemia can occasionally be observed during viral hepatitis, but severe hemolysis has previously only been reported in a few patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We report a case of massive acute hemolysis associated with an acute hepatitis A in a 39-year-old woman in the absence of G...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：:Transanal endoscopic microsurgery (TEM) presents a minimally invasive procedure for local removal of large rectal adenomas (>/= 2 cm) and early, so called "low-risk" carcinomas (uT1, G1 - 2) in curative as well as of advanced tumors in palliative intent. Over a 6-year period 92 TEM excisions of rectal tumors were carr...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-2002-20210
更新日期：2002-02-01 00:00:00
abstract：:The objectives of this report are to: 1) compare the Crohn's disease (CD) patient's assessment of their well-being to the physician's assessment of the patient's well-being, 2) use the existing Crohn's disease indices (CDI) in comparing the severity of CD with the patient's self assessment, and 3) compare the CDI with...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:After nine weeks of combination therapy with recombinant interferon-alpha and ribavirin for chronic hepatitis C a 62-year old woman complained of a dry cough and exertional dyspnea. An elevated erythrocyte sedimentation rate was noticed. Prior to treatment chest X-rays and physical examination revealed no pulmonary ab...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-2002-33879
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVE:Cost diaries administered by patients have been used as a method to measure costs for different diseases. Our aim was to test the application of a patient cost diary in patients with inflammatory bowel disease (IBD) and to measure disease specific resource utilization and costs. PATIENTS AND METHODS:A specif...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-2002-25153
更新日期：2002-04-01 00:00:00
abstract：:This article gives an overview on possible new pharmacological tools to modify gastrointestinal motility and/or secretion. The characterization of new subclasses of classical neurotransmitter receptors and of peptidergic receptors offer a new approach for the development of new therapeutic agents. Using molecular biol...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章,评审
doi：
更新日期：1991-04-01 00:00:00
abstract：:1977 cases with gastric complains but without localized findings like ulcer or cancer were investigated by gastroscopy with biopsies of corpus and antrum ventriculi. We found in 5.5% an isolated mucosal atrophy of the gastric corpus (mean age 67.2 years compared to 59.4 years in cases with normal mucosa). 0.7% showed ...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：:Portal hypertension in patients with liver cirrhosis can be improved, not only by surgical or interventional shunt placements, but also by drug-only treatment. Many recent studies addressed the question whether any of these substances can improve survival of patients with liver cirrhosis when administered continuously...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章,评审
doi：10.1055/a-0958-2788
更新日期：2019-08-01 00:00:00
abstract：:We investigated the long-term effect of interferon-alpha treatment in patients with chronic hepatitis B with regard to the response status during treatment. 97 patients with chronic hepatitis B, including 18 patients with active cirrhosis Child A, were followed for 12-110 months (mean: 40.5 months) after interferon-al...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:Cystic fibrosis is the most common lethal genetic disease in Caucasian population. End-stage lung disease is the most frequent cause of death, however since therapeutic options have improved the life expectancy of patients with cystic fibrosis, increased incidences of gastrointestinal tumors including pancreatic carci...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-0033-1356225
更新日期：2014-01-01 00:00:00
abstract：:Diathermocoagulation is indispensable in interventional endoscopy. The argon beam coagulation represents an innovative electrocoagulation method, where high-frequency alternating current is conducted to tissues by ionized argon gas without contact. Before clinical application we performed in vitro studies to evaluate ...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:Because of the central importance of the liver for the metabolism of estrogens and androgens the chronically ill liver per se represents an essential disturbing factor within the hypothalamic-pituitary-gonadal axis caused by the altered hepatic metabolism of the steroid hormones as well as the abnormal synthesis of st...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章,评审
doi：
更新日期：1979-07-01 00:00:00
abstract：:Common causes of chronically elevated serum liver enzymes include fatty liver disease, chronic viral hepatitis, autoimmune hepatitis, or hereditary metabolic disorders. Adrenocortical insufficiency can also cause elevated liver enzymes. Since 1990 only 11 cases have been reported. We here report a 52-year-old man with...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-2005-858976
更新日期：2006-02-01 00:00:00
abstract：:Chronic hepatitis C virus infection can be associated with mixed cryoglobulinemia and systemic vasculitis. The pathogenesis remains poorly understood. 55 consecutive patients with chronic HCI infection (anti-HCV- and serum HCV RNA-positive) were studies prospectively. Cryoglobulinemia was detected in 28 patients (51%)...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：:A 29-year-old man presented with abdominal cramps and bloody diarrhoea. Blood tests revealed elevated C-reactive protein (21.3 mg/dL; normal range 0.01 - 0. 82 mg/dL) and white blood cells (28200/μL, normal range 4000 - 10000/μL). Stool tests were negative for enteropathogenic bacteria and Clostridium difficile toxins...
journal_title：Zeitschrift fur Gastroenterologie
pub_type： 杂志文章
doi：10.1055/s-0031-1299289
更新日期：2012-02-01 00:00:00
