Coombs-negative severe hemolysis associated with hepatitis A.

Abstract:

:Mild anemia can occasionally be observed during viral hepatitis, but severe hemolysis has previously only been reported in a few patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We report a case of massive acute hemolysis associated with an acute hepatitis A in a 39-year-old woman in the absence of G6PD-deficiency. The patient was also suffering from mild rheumatoid arthritis. All known factors responsible for hemolysis were ruled out. Although tests for autoimmune hemolytic anemia were negative the patient made a dramatic recovery after treatment with corticosteroids, suggesting an immune mediated mechanism nonetheless.

journal_name

Z Gastroenterol

authors

Ibe M,Rüde B,Gerken G,Meyer zum Büschenfelde KH,Lohse AW

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

567-9

issue

7

eissn

0044-2771

issn

1439-7803

journal_volume

35

pub_type

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