["Iatrogenic acute coronary syndrome"--59 year old patient with adenocarcinoma of ascending colon and stenocardia while receiving adjuvant chemotherapy with 5-fluorouracil].

Abstract:

:Fluorouracil-associated cardiotoxic adverse events represent a relevant but underestimated problem in 5-fluorouracil treatment. After right hemicolectomy for adenocarcinoma of the rightsided colonic flexure a 59-year old patient was referred to our hospital for adjuvant chemotherapy according to MOSAIC-protocol with oxaliplatin and 5-fluorouracil. The patient's history was unremarkable for any cardiopulmonary disease and for any cardiovascular risk factors. 24 hours after completing the first cycle the patient was readmitted to our emergency department because of thoracic pain combined with significantly elevated cardiac enzymes and ischaemic changes in ECG. Coronary angiography was performed revealing no coronary artheriosclerosis. Clinical symptoms and pathological ischaemic serum parameters returned to normal range within 12 hours. Diagnosis of 5-FU-induced acute coronary syndrome could be made. Because of the high rate of recurring cardiotoxicity the patient's chemotherapy was modified to an alternative regimen containing raltitrexed instead of 5-fluorouracil. Immediate diagnosis of 5-FU-induced cardiotoxicity and differentiation from preexisting coronary heart disease is still a major problem in daily oncological practice.

journal_name

Z Gastroenterol

authors

Gundling F,Fuchs M,Nowak L,Antoni D,Hoffmann E,Schepp W

doi

10.1055/s-2006-927004

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

975-9

issue

9

eissn

0044-2771

issn

1439-7803

journal_volume

44

pub_type

杂志文章
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    pub_type: 杂志文章

    doi:

    authors: Kaufmann HP,Ottenjann R

    更新日期:1991-10-01 00:00:00

  • [Alcoholic liver disease--established treatment and new therapeutic approaches].

    abstract::Alcoholic liver disease is the most frequent organ damage encountered in chronic alcoholics and the annual death rate attributed to alcohol-induced end-stage liver disease exceeds that of car accidents. Alcoholic liver damage occurs mainly due to the toxicity of its first metabolite acetaldehyde, and due to interactio...

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    pub_type: 杂志文章,评审

    doi:10.1055/s-2003-38646

    authors: Stickel F,Seitz HK,Hahn EG,Schuppan D

    更新日期:2003-04-01 00:00:00

  • [Collagen colitis and lymphocytic (microscopic) colitis: different or common origin?].

    abstract::Collagenous and lymphocytic colitis are two chronic inflammatory colonic diseases characterized by chronic watery diarrhea. They can only be diagnosed by histological examination of colonic biopsies. The pathogenesis is unknown, but may be of an inflammatory possibly autoimmune nature. Others hypothesize that a bacter...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章,评审

    doi:

    authors: Netzer P,Levkovits H,Zimmermann A,Halter F

    更新日期:1997-09-01 00:00:00

  • [Autoradiography determination of the GABA(A) receptor density in the brain of rats with portacaval shunt].

    abstract::Quantitative autoradiography was used to assess the densities of gamma-aminobutyric acid (GABAA) receptors in the brains of rats with a portacaval end-to-side shunt (PCA). The shunt alone induced only mild encephalopathy with ataxia and decreased locomotion. Aggravation of the encephalopathy was achieved by gavage fee...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Rössle M,Deckert J,Mullen KD,Jones DB,Grün M,Gerok W,Jones EA

    更新日期:1990-03-01 00:00:00

  • [Lithogenicity and bile acid pattern in choleretic administration (3-n-butoxy-1-phenoxy-propanol: febuprol) in patients with functional right upper quadrant pain].

    abstract::10 patients with right upper quadrant pain were treated with a choleretic agent (Febuprol; 3 X 200 mg t. i. d.) and placebo in a cross-over double dummy technique for 16 weeks. Lithogenic index, bile acid profile and serum lipids were determined every 4 weeks. During Febuprol application the clinical symptoms were rel...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 临床试验,杂志文章

    doi:

    authors: Swobodnik W,Wechsler JG,Klüppelberg U,Janowitz P,Hutt V,Ditschuneit H

    更新日期:1987-11-01 00:00:00

  • Interstitial pneumonitis during combination therapy with interferon-alpha and ribavirin in a patient with chronic Hepatitis C.

    abstract::After nine weeks of combination therapy with recombinant interferon-alpha and ribavirin for chronic hepatitis C a 62-year old woman complained of a dry cough and exertional dyspnea. An elevated erythrocyte sedimentation rate was noticed. Prior to treatment chest X-rays and physical examination revealed no pulmonary ab...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:10.1055/s-2002-33879

    authors: Rothfuss KS,Bode JC

    更新日期:2002-09-01 00:00:00

  • [Mirizzi syndrome and its variants].

    abstract::Between 1981 and 1987 5434 patients were studied by ERCP in Allgemeines Krankenhaus Hamburg-Barmbeck. 26 (i.e. 0.43%) suffered from Mirizze syndrome with the triad of cholelithiasis, cholecystitis and obstructive biliary disease. They were classified in four different types according to the variable localisation and o...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Meyer GJ,Runge D,Gebhardt J

    更新日期:1990-04-01 00:00:00

  • [The role of acid in ulcer pain (author's transl)].

    abstract::In 33 patients (duodenal ulcer 11, gastric ulcer 10, nonulcerous bulbar lesions 7, anastomotic ulcer 4, antral erosions 1), approximately 4 ml HCL 0,1 N were instilled under endoscopic view directly onto the lesion, with the purpose of eliciting patients-specific pain. Five (5) patients were test-positive; their pain ...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Weithofer G,Langbein G,Lübke H,Bloch R

    更新日期:1981-05-01 00:00:00

  • [The histology of gastric mucosa in B II-stomach (author's transl)].

    abstract::131 patients operated on for gastric ulcer according to Gillroth II were investigated with gastroscopy and biopsy. The histology of the gastric mucosa was correlated with the time elapsed since resection. In most cases gastritis shows no difference between anastomosis and stump. In up to 12% gastritis in the stump was...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Lechner HJ,Anton D

    更新日期:1979-09-01 00:00:00

  • [Probiotics as therapeutic agents in irritable bowel syndrome].

    abstract::Probiotics are defined as living micro-organisms which, when administered in large amounts, confer a health benefit on the host. The use of probiotics in the therapy of infectious bowel diseases as well as maintaining remission of ulcerative colitis and in pouchitis is evidence-based. Also, in several studies proof co...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章,meta分析

    doi:10.1055/s-2004-813934

    authors: Krammer HJ,Schlieger F,Harder H,Franke A,Singer MV

    更新日期:2005-05-01 00:00:00

  • [NASH -- nonalcoholic steatohepatitis].

    abstract::Nonalcoholic steatohepatitis describes a hepatic disorder with the typical characteristics of an alcoholic pathogenesis without alcohol consumption. It was first described in 1962 and named NASH by Ludwig et al. 1980. Many researchers worked on this disease since this time. It represents the hepatic manifestation of t...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章,评审

    doi:10.1055/s-2003-36679

    authors: Blechacz B,Stremmel W

    更新日期:2003-01-01 00:00:00

  • [Cystic neoplasms of the pancreas: surgical therapy and chances for cure].

    abstract::Between 1986 and 1997 we treated 67 patients with 68 cystic tumors of the pancreas including 17 mucinous cystadenocarcinomas, four serous cystadenocarcinomas, 15 mucinous cystadenomas, 18 serous cystadenomas, ten intraductal papillary-mucinous tumors, three solid-pseudopapillary tumors, and one cystic neuroendocrine t...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Schmidt-Rohlfing B,Siech M,Mattfeldt T,Schoenberg MH,Beger HG

    更新日期:1998-11-01 00:00:00

  • [Determination of bile acids by radioimmunoassays (author's transl)].

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    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Matern S,Gerok W

    更新日期:1978-03-01 00:00:00

  • [Fibrolamellar liver cell cancer. A case report].

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    pub_type: 杂志文章

    doi:

    authors: Kahle M,Heilmann KL,Filler RD

    更新日期:1989-06-01 00:00:00

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    abstract::We studied the effect of two peptides, the intracellular Ca2(+)-mobilizing caerulein and the cAMP-mediated secretin, and also the phosphodiesterase inhibitor caffeine on pancreatic secretion and growth in newborn rats. To investigate the secretory response of these substances, and to construct dose-response curves 10-...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Papp M,Ammann RW,Dobronyl I,Varga G

    更新日期:1990-04-01 00:00:00

  • Prolongation of the QTc-interval reflects the severity of autonomic neuropathy in primary biliary cirrhosis and in other non-alcoholic liver diseases.

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    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Kempler P,Szalay F,Váradi A,Keresztes K,Kádár E,Tánczos E,Petrik J

    更新日期:1993-02-01 00:00:00

  • [Addison's disease as a rare cause of chronically elevated liver enzymes].

    abstract::Common causes of chronically elevated serum liver enzymes include fatty liver disease, chronic viral hepatitis, autoimmune hepatitis, or hereditary metabolic disorders. Adrenocortical insufficiency can also cause elevated liver enzymes. Since 1990 only 11 cases have been reported. We here report a 52-year-old man with...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:10.1055/s-2005-858976

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    更新日期:2006-02-01 00:00:00

  • [Frequency and pathogenesis of epitheloid cell granuloma in Crohn's disease (author's transl)].

    abstract::12% of the rectal biopsies (19% of the patients) showed epitheloid cell granulomas in clinically definite Crohn's disease. In colonic biopsies such granulomata were visible in 14% (22% of the patients). Granulomata were scarcely seen in normal or slightly inflamed mucosa. They were mostly found together with crypt abs...

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    pub_type: 杂志文章

    doi:

    authors: Schmitz-Moormann P,Malchow H,Miller B,Brandes JW

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  • [S3-guidelines for diagnosis and treatment of gallstones. German Society for Digestive and Metabolic Diseases and German Society for Surgery of the Alimentary Tract].

    abstract::This guideline provides evidence-based key recommendations for diagnosis and therapy of gallstones and upgrades version 2000. It was developed by an interdisciplinary team of gastroenterologists, surgeons, radiologists, geneticists, external comparative quality assurance and patient support groups under the auspices o...

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    pub_type: 杂志文章,实务指引

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  • [Diagnosis of functional esophageal disorders in non-cardiac chest pain syndrome].

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    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章,评审

    doi:

    authors: Adamek RJ,Wegener M,Wienbeck M

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  • [Antibiotic-associated segmental hemorrhagic colitis: a case report].

    abstract::Pseudomembranous colitis is a well known complication of antibiotic therapy. Only recently few cases of another form of an antibiotic-associated colitis, the acute segmental haemorrhagic penicillin-associated colitis, have been described. We report another case and point out the importance of early colonoscopy to dist...

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    pub_type: 杂志文章

    doi:

    authors: Flueckiger T,Froehli P,Baltisser I

    更新日期:1992-04-01 00:00:00

  • [Gallstone formation following transmural migration of a surgical clip in the bile ducts. Case report].

    abstract::Foreign bodies as a nucleus for precipitation of gall-stones are not frequently observed. The combination of primary immigrated foreign bodies into the bile ducts and following encasing by a gall-stone could be even more rarely found. A case report is presented concerning a patient, in whom a hemo-clip was fixed away ...

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    pub_type: 杂志文章

    doi:

    authors: Wittenberg H,Freise J,Meyer HJ,Then P

    更新日期:1985-03-01 00:00:00

  • [Updated S2k-Guideline "Complications of liver cirrhosis". German Society of Gastroenterology (DGVS)].

    abstract::This guideline provides evidence-based key recommendations for diagnosis and therapy of complications of liver cirrhosis and upgrades the 2011 version. An interdisciplinary team of medical experts and patient support groups developed the guideline following the AWMF recommendations for evidence based consensus guideli...

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    doi:10.1055/a-0873-4658

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  • Intestinal zinc absorption in cirrhotic patients.

    abstract::We studied intestinal zinc absorption and daily urinary zinc excretion in 13 healthy controls and 27 cirrhotic patients (14 alcoholics, 13 non-alcoholics) with normal serum creatinine levels. Intestinal zinc absorption was determined by the oral zinc tolerance test. Serum levels were significantly lower in cirrhotics,...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Solis-Herruzo J,De Cuenca B,Muñoz-Rivero MC

    更新日期:1989-06-01 00:00:00

  • [Endoscopic tumor-cell diagnosis within the region of duodenum].

    abstract::The technique spontaneously or siphoned after cholecystokinin stimulation. Our technique of cell collection within the region of the duodenum, the pancreas and the bile-ducts have been optimal performed by duodenoscopical methods. From the papilla of Vater, the cell brush abrasion is used. Pancreatic secretions are ob...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Witte S

    更新日期:1976-07-01 00:00:00

  • [Controlled evaluation of a high-resolution three-dimensional magnetic detector system (3D-MAGMA) as a proof of concept - examination of healthy volunteers before and after application of Metoclopramide (MCP)].

    abstract:BACKGROUND:Changes in gastric and small bowel motility are a common clinical problem. Currently diagnostic options are limited because each method harbors certain disadvantages. It has been shown that the high-resolution three-dimensional magnetic detector system 3D-MAGMA is capable of reliably measuring gastric and sm...

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    pub_type: 杂志文章

    doi:10.1055/s-0042-100285

    authors: Jacob VY,Stallmach A,Felber J

    更新日期:2016-06-01 00:00:00

  • [Reliability of the diagnosis of chronic pancreatitis].

    abstract::Severe chronic pancreatitis can be easily diagnosed by means of pancreatic function tests and/or imaging procedures, whereas the mild form of the disease or its early stages are more difficult to detect and are often only retrospectively diagnosed. The reliability of imaging procedures depends mainly on the experience...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章,评审

    doi:

    authors: Lankisch PG,Staritz M,Freise J

    更新日期:1990-05-01 00:00:00

  • Pharmacological treatment of hepatocellular carcinoma with cavoatrial tumor thrombus - case series and literature review.

    abstract::Hepatocellular carcinomas (HCC) that extend into the vena cava and the right atrium have a poor prognosis. Surgical approaches including partial hepatectomy and thrombectomy are the most frequently reported treatment options. However, most patients with advanced HCC are not eligible for complex surgical interventions ...

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    pub_type: 杂志文章,评审

    doi:10.1055/a-0855-4469

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    更新日期:2019-04-01 00:00:00

  • Cryoglobulinemia in chronic hepatitis C virus infection: prevalence, clinical manifestations, response to interferon treatment and analysis of cryoprecipitates.

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    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Hartmann H,Schott P,Polzien F,Mihm S,Uy A,Kaboth U,Pardowitz I,Ramadori G

    更新日期:1995-11-01 00:00:00

  • [Radioimmunoassay of prostaglandins (author's transl)].

    abstract::Prostaglandins (PGs) can be measured by bioassay or combined gas-chromatography/mass spectrometry or by radioimmunoassay. The main advantage of the latter method is its great sensitivity. On the other hand, difficulties, with this method can arise from the small molecular weight of PGs and the large number of structur...

    journal_title:Zeitschrift fur Gastroenterologie

    pub_type: 杂志文章

    doi:

    authors: Peskar BM

    更新日期:1978-05-01 00:00:00