Contrast discrimination: a model and a hypothesis concerning the role of cholinergic modulation in contrast perception.

Abstract:

:A model of contrast discrimination performance in human observers is developed and then extended to cover effects on performance of anticholinergic drugs. It is shown that it is necessary to assume that neural noise increases at high spatial frequencies in order to provide a satisfactory model of variations in discrimination performance with spatial frequency. The model results are compared with the results of empirical studies in which the effects of the muscarinic antagonist scopolamine (hyoscine) on contrast discrimination performance in human observers are examined. The purpose of the pharmacological work is to test the hypothesis that the differential contrast gain found psychophysically at different spatial frequencies might reflect differential facilitation by extrinsic cholinergic neurons. Contrast discrimination and contrast increment detection are found to be impaired by scopolamine in a manner that depends on both spatial frequency and base contrast. By comparing the empirical data with the predictions of the model, it is concluded that contrast constancy may reflect differential cholinergic modulation.

journal_name

Vis Neurosci

journal_title

Visual neuroscience

authors

Smith AT

doi

10.1017/s0952523800009123

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

873-84

issue

5

eissn

0952-5238

issn

1469-8714

pii

S0952523800009123

journal_volume

13

pub_type

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