Abstract:
:We examined the effects of picrotoxin and pentylenetetrazol (PTZ) on the responses to motions of ON-OFF directionally selective (DS) ganglion cells of the turtle's retina. These drugs are antagonists of the inhibitory neurotransmitter GABA. For continuous motions, picrotoxin markedly reduced the overall directionality of the cells. In 21% of the cells, directional selectivity was lost regardless of speed and contrast. However, other cells maintained their preferred direction despite saturating concentrations of picrotoxin. And in most cells, loss, maintenance, or even reversal of preferred and null directions could occur as speed and contrast were modulated. In 50% of the cells, reversal of preferred and null directions occurred at some condition of visual stimuli. However, picrotoxin did not tend to alter the preferred-null axis for directional selectivity. For apparent motions, picrotoxin made motion facilitation, which normally occurs exclusively in preferred-direction responses, to become erratic and often occur during null-direction motions. Finally, PTZ had effects similar to picrotoxin but with less potency. The results in this paper indicated that models of directional selectivity based solely on a GABAergic implementation of Barlow and Levick's asymmetric-inhibition model do not apply to the turtle retina. Alternative models may comprise multiple directional mechanisms and/or a symmetric inhibitory one, but not asymmetric facilitation.
journal_name
Vis Neuroscijournal_title
Visual neuroscienceauthors
Smith RD,Grzywacz NM,Borg-Graham LJdoi
10.1017/s0952523800008105subject
Has Abstractpub_date
1996-05-01 00:00:00pages
423-39issue
3eissn
0952-5238issn
1469-8714pii
S0952523800008105journal_volume
13pub_type
杂志文章abstract::Recent work has revealed multiple pathways for cross-orientation suppression in cat and human vision. In particular, ipsiocular and interocular pathways appear to assert their influence before binocular summation in human but have different (1) spatial tuning, (2) temporal dependencies, and (3) adaptation after-effect...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/S095252380808070X
更新日期:2008-07-01 00:00:00
abstract::Wide-field cone bipolar cells with sparse dendritic branching and proposed connectivity to blue cones were first identified in rabbit and cat. In rabbit, these were subdivided into type a (wa) and type b (wb), with axonal branching in sublamina a, and sublamina b, respectively, of the inner plexiform layer (IPL). Rece...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/S0952523808080061
更新日期:2008-01-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800004351
更新日期:1989-01-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523803202091
更新日期:2003-03-01 00:00:00
abstract::Adult teleost fish retinas can regenerate neurons following either surgical or pharmacological injury. The cellular milieu of the damaged retina within which regenerated neurons are produced might be different in these two model systems of retinal injury, and thus the phenotypic attributes of regenerated neurons in th...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800174115
更新日期:2000-07-01 00:00:00
abstract::Transgenic mice overexpressing bcl-2, due to inhibition of naturally occurring cell death, have much larger brains and optic nerves as compared to wild-type mice. Since developmental cell death is believed to exert a crucial role in establishing the mature neural circuitry and function, we asked the question of whethe...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523899164113
更新日期:1999-07-01 00:00:00
abstract::Fish of the genus Anableps (Anablepidae, Cyprinodontiformes) have eyes that are adapted for simultaneous aerial and aquatic vision. In this study we investigate some of the corresponding retinal specializations of the adult Anableps anableps eye using retinal transverse sections and wholemounts. The linear dimensions ...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/S0952523806230232
更新日期:2006-11-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/S0952523804215073
更新日期:2004-09-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800009573
更新日期:1992-08-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s095252380000897x
更新日期:1995-07-01 00:00:00
abstract::Immunocytochemistry and retrograde labeling were used to define the thalamic projections of calbindin- and parvalbumin-containing cells in superficial layers of the rat's superior colliculus (SC). Quantitative analysis revealed that 90.8 +/- 2.2% (mean +/- standard deviation) of the calbindin-immunoreactive neurons in...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s095252380001141x
更新日期:1997-03-01 00:00:00
abstract::The neural mechanisms driving perception and saccades during search use information about the target but are also based on an inhibitory surround not present in the target luminance profile (e.g., Eckstein et al., 2007). Here, we ask whether these inhibitory surrounds might reflect a strategy that the brain has adapte...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/S0952523809090014
更新日期:2009-01-01 00:00:00
abstract::The inhibition of [3H]acetylcholine (ACh) release from cholinergic amacrine cells by glycine and GABA was studied using an in vivo eyecup preparation in anesthetized rabbits. Glycine (1 mM) had no effect on basal ACh release, but completely blocked the light-evoked release of ACh. Glycine also blocked the strong poten...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523898156067
更新日期:1998-11-01 00:00:00
abstract::Anterograde transport of cholera toxin subunit B (CTb) was used to study the retinal projections in birds, with an emphasis on retinohypothalamic connections. Pigeons (Columbia livia) were deeply anesthetized and received unilateral intraocular injections of CTb. In addition to known contralateral retinorecipient regi...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800002376
更新日期:1994-05-01 00:00:00
abstract::The ability of freely-flying honeybees to track moving targets was examined by training them to collect a reward on a target, and then videotaping their approach to the target while it was in motion. Training experiments were carried out with several groups of bees, using various colors for the target and the backgrou...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800004582
更新日期:1990-04-01 00:00:00
abstract::The outer plexiform layer of the retina contains a neural circuit in which cone synaptic terminals are electrically coupled and release glutamate onto wide-field and narrow-field horizontal cells. These are also electrically coupled and feed back through a GABAergic synapse to cones. In cat this circuit's structure is...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800008440
更新日期:1995-05-01 00:00:00
abstract::This study used the swept spatial-frequency method to compare retinal and cortical acuity in anesthetized young adult rhesus monkeys. Visual evoked potentials (VEPs) and pattern electroretinographic responses (PERGs) were recorded from 25 monkeys (age range: 4-12 years) anesthetized with a continuous infusion of propo...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523899164010
更新日期:1999-07-01 00:00:00
abstract::Many cell types in the retina are coupled via gap junctions and so there is a pressing need for a potent and reversible gap junction antagonist. We screened a series of potential gap junction antagonists by evaluating their effects on dye coupling in the network of A-type horizontal cells. We evaluated the following c...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/S0952523807070472
更新日期:2007-07-01 00:00:00
abstract::Single isolated photoreceptors can be taken through a visual cycle of light adaptation by bleaching visual pigment, followed by dark adaptation when supplied with 11-cis retinal. Light adaptation after bleaching is manifested by faster response kinetics and a permanent reduction in sensitivity to light flashes, presum...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800001735
更新日期:1994-03-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523899163107
更新日期:1999-05-01 00:00:00
abstract::Alpha ganglion cells from the midperiphery of the rabbit retina were recorded intracellularly under visual control, in a superfused everted eyecup, and labeled with HRP. Their physiology and large somata with broad dendritic arbors identified them as uniform populations of ON- and OFF-center alpha ganglion cells, whic...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800011512
更新日期:1997-03-01 00:00:00
abstract::The retina of salmonid fishes has two types of cone photoreceptors: single and double cones. At the nuclear level, these cones are distributed in a square mosaic such that the double cones form the sides of the square and the single cones occupy positions at the centre and at the corners of the square. Double cones co...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/S0952523807070137
更新日期:2007-05-01 00:00:00
abstract::To explore the possible influence of defined genetic backgrounds on photoreceptor viability and function in mice carrying a targeted disruption of the rhodopsin gene, the severities of retinopathies in Rho-/- mice on C57BL/6J and 129Sv congenic backgrounds were compared by light microscopy and electroretinography and ...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523801183100
更新日期:2001-05-01 00:00:00
abstract::Increment threshold functions of the electroretinogram (ERG) b-wave were obtained from goldfish using an in vivo preparation to study intraretinal mechanisms underlying the increase in perceived brightness induced by depletion of retinal dopamine by 6-hydroxydopamine (6-OHDA). Goldfish received unilateral intraocular ...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s095252380000300x
更新日期:1994-07-01 00:00:00
abstract::Reduction of blood flow to the rat retina was achieved by either clamping both carotid arteries briefly (24 min) or combining clamping of the carotid arteries with permanent occlusion of the vertebral arteries. Analysis of retinas 6 days after operations showed that GFAP immunoreactivity is expressed throughout the re...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800010427
更新日期:1991-12-01 00:00:00
abstract::The distribution of GABA-like immunoreactivity in the pigeon visual system was studied during the first 9 days after hatching using a mouse monoclonal antibody, mAb 3A12, to glutaraldehyde linked GABA (Matute & Streit, 1986). GABA-like immunoreactivity was seen in cell bodies as well as in neuropil at the level of bot...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800009846
更新日期:1989-12-01 00:00:00
abstract::Effects of ATP on the activity of cGMP-gated channels from carp cone photoreceptors were studied. In 29% of the patches examined (N = 45), ATP (1 mM) enhanced a current evoked by cGMP (20 microM, up to about 100%), in 33%. ATP suppressed it by up to about 90%, and in the remaining 38%, ATP had no effect. ATP showed si...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800012578
更新日期:1997-07-01 00:00:00
abstract::The distribution of GABA-like immunoreactivity in the cat retina was studied through the use of preembedding immunocytochemistry for light microscopy and by postembedding immunogold techniques for electron microscopy. Staining was observed in both inner and outer plexiform layers. Approximately 30% of the somata in th...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800012323
更新日期:1989-01-01 00:00:00
abstract::Starburst amacrine cells (SACs), the only acetylcholine (ACh)-releasing amacrine cells (ACs) in adult rabbit retina, contain GABA and are key elements in the retina's directionally selective (DS) mechanism. Unlike many other GABAergic ACs, they use glutamic acid decarboxlyase (GAD)(67), not GAD(65), to synthesize GABA...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/S0952523810000052
更新日期:2010-03-01 00:00:00
abstract::We recorded the responses of neurons from the cat's lateral geniculate nucleus to drifting sine-wave grating stimuli both before and during electrical stimulation of the parabrachial region of the midbrain. The parabrachial region provides a mostly cholinergic input to the lateral geniculate nucleus, and our goal was ...
journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800005332
更新日期:1993-07-01 00:00:00