Vision in mice with neuronal redundancy due to inhibition of developmental cell death.

Abstract:

:Transgenic mice overexpressing bcl-2, due to inhibition of naturally occurring cell death, have much larger brains and optic nerves as compared to wild-type mice. Since developmental cell death is believed to exert a crucial role in establishing the mature neural circuitry and function, we asked the question of whether basic aspects of vision were altered in bcl-2 mice. Local visually evoked potentials (VEPs) in response to patterned stimuli were recorded from the primary visual cortex. The representation of the vertical meridian was displaced by about 15% in the bcl-2 mouse, accounting for brain expansion. However, visual acuity, contrast threshold, and response latency were normal, indicating that compensatory mechanisms can ensure normal basic properties of vision in spite of marked neuronal redundancy.

journal_name

Vis Neurosci

journal_title

Visual neuroscience

authors

Porciatti V,Pizzorusso T,Maffei L

doi

10.1017/s0952523899164113

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

721-6

issue

4

eissn

0952-5238

issn

1469-8714

pii

S0952523899164113

journal_volume

16

pub_type

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