Modulatory actions of serotonin, norepinephrine, dopamine, and acetylcholine in spinal cord deep dorsal horn neurons.

Abstract:

:The deep dorsal horn represents a major site for the integration of spinal sensory information. The bulbospinal monoamine transmitters, released from serotonergic, noradrenergic, and dopaminergic systems, exert modulatory control over spinal sensory systems as does acetylcholine, an intrinsic spinal cord biogenic amine transmitter. Whole cell recordings of deep dorsal horn neurons in the rat spinal cord slice preparation were used to compare the cellular actions of serotonin, norepinephrine, dopamine, and acetylcholine on dorsal root stimulation-evoked afferent input and membrane cellular properties. In the majority of neurons, evoked excitatory postsynaptic potentials were depressed by the bulbospinal transmitters serotonin, norepinephrine, and dopamine. Although, the three descending transmitters could evoke common actions, in some neurons, individual transmitters evoked opposing actions. In comparison, acetylcholine generally facilitated the evoked responses, particularly the late, presumably N-methyl-D-aspartate receptor-mediated component. None of the transmitters modified neuronal passive membrane properties. In contrast, in response to depolarizing current steps, the biogenic amines significantly increased the number of spikes in 14/19 neurons that originally fired phasically (P < 0.01). Together, these results demonstrate that even though the deep dorsal horn contains many functionally distinct subpopulations of neurons, the bulbospinal monoamine transmitters can act at both synaptic and cellular sites to alter neuronal sensory integrative properties in a rather predictable manner, and clearly distinct from the actions of acetylcholine.

journal_name

J Neurophysiol

authors

Garraway SM,Hochman S

doi

10.1152/jn.2001.86.5.2183

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

2183-94

issue

5

eissn

0022-3077

issn

1522-1598

journal_volume

86

pub_type

杂志文章
  • A-current and type I/type II transition determine collective spiking from common input.

    abstract::The mechanisms and impact of correlated, or synchronous, firing among pairs and groups of neurons are under intense investigation throughout the nervous system. A ubiquitous circuit feature that can give rise to such correlations consists of overlapping, or common, inputs to pairs and populations of cells, leading to ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00928.2011

    authors: Barreiro AK,Thilo EL,Shea-Brown E

    更新日期:2012-09-01 00:00:00

  • A system for recording neural activity chronically and simultaneously from multiple cortical and subcortical regions in nonhuman primates.

    abstract::A major goal of neuroscience is to understand the functions of networks of neurons in cognition and behavior. Recent work has focused on implanting arrays of ∼100 immovable electrodes or smaller numbers of individually adjustable electrodes, designed to target a few cortical areas. We have developed a recording system...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00625.2011

    authors: Feingold J,Desrochers TM,Fujii N,Harlan R,Tierney PL,Shimazu H,Amemori K,Graybiel AM

    更新日期:2012-04-01 00:00:00

  • Eye alignment in kittens.

    abstract::1. The alignment of the pupillary axes and of the visual axes has been measured in 23 normally reared cats ranging in age from 14 days to adulthood. 2. In agreement with a previous report, we find that pupillary divergence, as measured from photographs, tends to decrease during the first 2 mo of life. 3. The angle bet...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1978.41.4.848

    authors: Olson CR,Freeman RD

    更新日期:1978-07-01 00:00:00

  • Context-dependent modulation of interlimb cutaneous reflexes in arm muscles as a function of stability threat during walking.

    abstract::Cutaneous reflexes evoked in the muscles of the arms with electrical stimulation of nerves of the foot ("interlimb reflexes") are observed during walking. These reflexes have been suggested to coordinate the actions of the legs and arms when walking is disturbed. Recently, we showed that cutaneous reflexes evoked in t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00746.2006

    authors: Haridas C,Zehr EP,Misiaszek JE

    更新日期:2006-12-01 00:00:00

  • Contractile properties of single motor units in human toe extensors assessed by intraneural motor axon stimulation.

    abstract::1. Single motor axons innervating human toe extensor muscles were selectively stimulated through a tungsten microelectrode inserted percutaneously into the peroneal nerve. Twitch and tetanic forces were measured from a strain gauge over the proximal phalanx of the toe generating the greatest force. Twitch data were ob...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1152/jn.1996.75.6.2509

    authors: Macefield VG,Fuglevand AJ,Bigland-Ritchie B

    更新日期:1996-06-01 00:00:00

  • Altered desensitization produces enhancement of EPSPs in neocortical neurons.

    abstract::1. Neocortical brain slices were prepared from rats (35-50 days of age) and maintained in vitro. Intracellular recordings were obtained from neurons in cortical layers II/III. The effect of bath application of cyclothiazide (CYZ), a potent blocker of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.2.1032

    authors: Pelletier MR,Hablitz JJ

    更新日期:1994-08-01 00:00:00

  • Push-pull mechanism of selective attention in human extrastriate cortex.

    abstract::Selective attention operates in visual cortex by facilitating processing of selected stimuli and by filtering out unwanted information from nearby distracters over circumscribed regions of visual space. The neural representation of unattended stimuli outside this focus of attention is less well understood. We studied ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00974.2003

    authors: Pinsk MA,Doniger GM,Kastner S

    更新日期:2004-07-01 00:00:00

  • Two-photon excitation of potentiometric probes enables optical recording of action potentials from mammalian nerve terminals in situ.

    abstract::We report the first optical recordings of action potentials, in single trials, from one or a few (approximately 1-2 microm) mammalian nerve terminals in an intact in vitro preparation, the mouse neurohypophysis. The measurements used two-photon excitation along the "blue" edge of the two-photon absorption spectrum of ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00929.2007

    authors: Fisher JA,Barchi JR,Welle CG,Kim GH,Kosterin P,Obaid AL,Yodh AG,Contreras D,Salzberg BM

    更新日期:2008-03-01 00:00:00

  • Slow sodium conductances of dorsal root ganglion neurons: intraneuronal homogeneity and interneuronal heterogeneity.

    abstract::1. Voltage-dependent Na+ conductances were studied in small (18-25 microns diam) adult rat dorsal root ganglion (DRG) neurons with the use of the whole cell patch-clamp technique. Na+ currents were also recorded from larger (44-50 microns diam) neurons and compared with those of the small neurons. 2. The predominant N...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.6.2796

    authors: Rizzo MA,Kocsis JD,Waxman SG

    更新日期:1994-12-01 00:00:00

  • Layer-specific serotonergic facilitation of IPSC in layer 2/3 pyramidal neurons of the visual cortex.

    abstract::Serotonin (5-hydroxytryptamine, 5-HT) inhibits the induction of long-term synaptic plasticity in layer 2/3 of the visual cortex at the end of its critical period in rats. However, the cellular and molecular mechanisms remain unclear. Since inhibitory influence is crucial in the induction of synaptic plasticity, the ef...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00535.2011

    authors: Jang HJ,Cho KH,Park SW,Kim MJ,Yoon SH,Rhie DJ

    更新日期:2012-01-01 00:00:00

  • Primate rubromotoneuronal cells: parametric relations and contribution to wrist movement.

    abstract::1. Fifty-nine rubromotoneuronal (RM) cells were identified in two rhesus monkeys on the basis of their postspike facilitation (PSpF) of rectified electromyographic (EMG) activity. These cells were studied in relation to a step tracking task requiring wrist movements between fixed target zones in flexion and extension....

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.1.14

    authors: Mewes K,Cheney PD

    更新日期:1994-07-01 00:00:00

  • Impulse rates and sensitivity to stretch of soleus muscle spindle afferent fibers during locomotion in premammillary cats.

    abstract::Impulse from soleus muscle afferents were recorded in premammillary cats that were walking on a treadmill. In normal walking the effects of gamma-motoneurons on impulse rates of muscle spindle afferents are confounded by the effects of the large length changes that occur. To isolate the effects of gamma-motoneurons th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1985.53.2.341

    authors: Taylor J,Stein RB,Murphy PR

    更新日期:1985-02-01 00:00:00

  • Modest increase in extracellular potassium unmasks effect of recurrent mossy fiber growth.

    abstract::The recurrent mossy fiber pathway of the dentate gyrus expands dramatically in many persons with temporal lobe epilepsy. The new connections among granule cells provide a novel mechanism of synchronization that could enhance the participation of these cells in seizures. Despite the presence of robust recurrent mossy f...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.84.5.2380

    authors: Hardison JL,Okazaki MM,Nadler JV

    更新日期:2000-11-01 00:00:00

  • Robotic therapy for chronic stroke: general recovery of impairment or improved task-specific skill?

    abstract::There is a great need to develop new approaches for rehabilitation of the upper limb after stroke. Robotic therapy is a promising form of neurorehabilitation that can be delivered in higher doses than conventional therapy. Here we sought to determine whether the reported effects of robotic therapy, which have been bas...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00336.2015

    authors: Kitago T,Goldsmith J,Harran M,Kane L,Berard J,Huang S,Ryan SL,Mazzoni P,Krakauer JW,Huang VS

    更新日期:2015-09-01 00:00:00

  • Noise-induced transition to bursting in responses of paddlefish electroreceptor afferents.

    abstract::The response properties of ampullary electroreceptors of paddlefish, Polyodon spathula, were studied in vivo, as single-unit afferent responses to external electrical stimulation with varied intensities of several types of noise waveforms, all Gaussian and zero-mean. They included broadband white noise, Ornstein-Uhlen...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01289.2006

    authors: Neiman AB,Yakusheva TA,Russell DF

    更新日期:2007-11-01 00:00:00

  • Characterization of voltage-gated K+ currents contributing to subthreshold membrane potential oscillations in hippocampal CA1 interneurons.

    abstract::CA1 inhibitory interneurons at the stratum lacunosum-moleculare and radiatum junction (LM/RAD-INs) display subthreshold membrane potential oscillations (MPOs) involving voltage-dependent Na(+) and A-type K(+) currents. LM/RAD-INs also express other voltage-gated K(+) currents, although their properties and role in MPO...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00848.2009

    authors: Morin F,Haufler D,Skinner FK,Lacaille JC

    更新日期:2010-06-01 00:00:00

  • Retinogeniculate synaptic properties controlling spike number and timing in relay neurons.

    abstract::Retinal ganglion cells (RGC) transmit visual signals to thalamocortical relay neurons in the lateral geniculate nucleus via retinogeniculate synapses. Relay neuron spike patterns do not simply reflect those of RGCs, but the mechanisms controlling this transformation are not well understood. We therefore examined synap...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00562.2003

    authors: Blitz DM,Regehr WG

    更新日期:2003-10-01 00:00:00

  • Alterations in development, behavior, and physiology in Drosophila larva that have reduced ecdysone production.

    abstract::We investigated behavior, physiology, sensitivity to exogenous application of ecdysone, and nerve terminal structure for differences between the reduced ecdysone genotype, ecd(1)/ecd(1), and wild-type control ecd(1)/TM6B animals during the early and late third instars when raised at 25 degrees C. The ecd(1) mutants we...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.85.1.98

    authors: Li H,Harrison D,Jones G,Jones D,Cooper RL

    更新日期:2001-01-01 00:00:00

  • The nature of V1 neural responses to 2D moving patterns depends on receptive-field structure in the marmoset monkey.

    abstract::A plaid pattern is formed when two sinusoidal gratings of different orientations are added together. Previous work has shown that V1 neurons selectively encode the direction and orientation of the component gratings in a moving plaid but not the direction of the plaid itself (Movshon et al. 1985). We recorded the resp...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00708.2002

    authors: Tinsley CJ,Webb BS,Barraclough NE,Vincent CJ,Parker A,Derrington AM

    更新日期:2003-08-01 00:00:00

  • Covert orienting of attention in macaques. I. Effects of behavioral context.

    abstract::1. A task was used by Posner (1980) to measure shifts of attention that occurred covertly, in the absence of an eye movement or other orienting response. This paradigm was used here to assess the nature of covert attentional orienting in monkeys to develop an animal model for neurophysiological studies. Shifts of atte...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.70.1.431

    authors: Bowman EM,Brown VJ,Kertzman C,Schwarz U,Robinson DL

    更新日期:1993-07-01 00:00:00

  • Spinal strychnine alters response properties of nociceptive-specific neurons in rat medial thalamus.

    abstract::Experiments in both conscious and anesthetized animals indicate that intrathecal (i.t.) strychnine (STR; glycine receptor antagonist) produces acute, reversible allodynia, as evidenced by inappropriate behavioral and autonomic responses to cutaneous tactile stimuli. Although STR is known to produce disinhibition of af...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.2.628

    authors: Sherman SE,Luo L,Dostrovsky JO

    更新日期:1997-08-01 00:00:00

  • Windup of flexion reflexes in chronic human spinal cord injury: a marker for neuronal plateau potentials?

    abstract::The physiological basis of flexion spasms in individuals after spinal cord injury (SCI) may involve alterations in the properties of spinal neurons in the flexion reflex pathways. We hypothesize that these changes would be manifested as progressive increases in reflex response with repetitive stimulus application (i.e...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00979.2001

    authors: Hornby TG,Rymer WZ,Benz EN,Schmit BD

    更新日期:2003-01-01 00:00:00

  • Dipole source analyses of early median nerve SEP components obtained from subdural grid recordings.

    abstract::The median nerve N20 and P22 SEP components constitute the initial response of the primary somatosensory cortex to somatosensory stimulation of the upper extremity. Knowledge of the underlying generators is important both for basic understanding of the initial sequence of cortical activation and to identify landmarks ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00116.2010

    authors: Baumgärtner U,Vogel H,Ohara S,Treede RD,Lenz FA

    更新日期:2010-12-01 00:00:00

  • Electrophysiological characteristics of rat gustatory cyclic nucleotide--gated channel expressed in Xenopus oocytes.

    abstract::The complementary DNA encoding gustatory cyclic nucleotide--gated ion channel (or gustCNG channel) cloned from rat tongue epithelial tissue was expressed in Xenopus oocytes, and its electrophysiological characteristics were investigated using tight-seal patch-clamp recordings of single and macroscopic channel currents...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.85.6.2335

    authors: Lee HM,Park YS,Kim W,Park CS

    更新日期:2001-06-01 00:00:00

  • Brief trains of action potentials enhance pyramidal neuron excitability via endocannabinoid-mediated suppression of inhibition.

    abstract::Depolarization-induced suppression of inhibition (DSI) is a form of retrograde signaling at GABAergic synapses that is initiated by the calcium- and depolarization-dependent release of endocannabinoids from postsynaptic neurons. In the neocortex, pyramidal neurons (PNs) appear to use DSI as a mechanism for regulating ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00351.2004

    authors: Fortin DA,Trettel J,Levine ES

    更新日期:2004-10-01 00:00:00

  • Noninvasive brain stimulation can elucidate and interact with the mechanisms underlying motor learning and retention: implications for rehabilitation.

    abstract::Seminal work in animals indicates that learning a motor task results in long-term potentiation (LTP) in primary motor cortex (M1) and a subsequent occlusion of LTP induction (Rioult-Pedotti et al. J Neurophysiol 98: 3688-3695, 2007). Using various forms of noninvasive brain stimulation in conjunction with a motor lear...

    journal_title:Journal of neurophysiology

    pub_type: 评论,杂志文章

    doi:10.1152/jn.00766.2013

    authors: Hinder MR,Reissig P,Fujiyama H

    更新日期:2014-03-01 00:00:00

  • Contributors to excess antagonist activity during movement in children with secondary dystonia due to cerebral palsy.

    abstract::Children with secondary dystonia due to cerebral palsy exhibit abnormal upper extremity postures and slow voluntary movement. However, the interaction between abnormal postures and abnormal movement in dystonia is still unclear. Some mechanisms by which postures are maintained in dystonia include stretch reflexes, ove...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00998.2009

    authors: Kukke SN,Sanger TD

    更新日期:2011-05-01 00:00:00

  • A novel paraplegia model in awake behaving macaques.

    abstract::Lower limb paralysis from spinal cord injury (SCI) or neurological disease carries a poor prognosis for recovery and remains a large societal burden. Neurophysiological and neuroprosthetic research have the potential to improve quality of life for these patients; however, the lack of an ethical and sustainable nonhuma...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00327.2017

    authors: Krucoff MO,Zhuang K,MacLeod D,Yin A,Byun YW,Manson RJ,Turner DA,Oliveira L,Lebedev MA

    更新日期:2017-09-01 00:00:00

  • Directionally sensitive ganglion cells in the rabbit retina: specificity for stimulus direction, size, and speed.

    abstract::The receptive fields of directionally sensitive ganglion cells in the rabbit retina were analyzed. Several types of experiment showed that each point within the receptive field of the cell is inhibited by a fairly wide area of points around it, lying on each side of the preferred-null axis as well as along the preferr...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1975.38.3.613

    authors: Wyatt HJ,Daw NW

    更新日期:1975-05-01 00:00:00

  • Entrainment of visual steady-state responses is modulated by global spatial statistics.

    abstract::The rhythmic delivery of visual stimuli evokes large-scale neuronal entrainment in the form of steady-state oscillatory field potentials. The spatiotemporal properties of stimulus drive appear to constrain the relative degrees of neuronal entrainment. Specific frequency ranges, for example, are uniquely suited for enh...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00129.2017

    authors: Nguyen T,Kuntzelman K,Miskovic V

    更新日期:2017-07-01 00:00:00