Brief trains of action potentials enhance pyramidal neuron excitability via endocannabinoid-mediated suppression of inhibition.

abstract：:Paired-pulse transcranial magnetic stimulation (TMS) and peripheral stimulation combined with TMS can be used to study cortical interneuronal circuitry. By combining these procedures with concurrent transcranial alternating current stimulation (tACS), Guerra and colleagues recently showed that different cortical inter...

journal_title：Journal of neurophysiology

authors： Hussain SJ,Thirugnanasambandam N

更新日期：2017-06-01 00:00:00

abstract：:We developed a variety of 54-channel high-density silicon electrode arrays (polytrodes) designed to record from large numbers of neurons spanning millimeters of brain. In cat visual cortex, it was possible to make simultaneous recordings from >100 well-isolated neurons. Using standard clustering methods, polytrodes pr...

journal_title：Journal of neurophysiology

authors： Blanche TJ,Spacek MA,Hetke JF,Swindale NV

更新日期：2005-05-01 00:00:00

abstract：:Attenuation of paired-pulse facilitation associated with synaptic potentiation mediated by postsynaptic mechanisms. J. Neurophysiol. 78: 2707-2716, 1997. The relationship between paired-pulse facilitation (PPF) and synaptic potentiation induced by various protocols and their cellular and molecular mechanisms were exam...

journal_title：Journal of neurophysiology

authors： Wang JH,Kelly PT

更新日期：1997-11-01 00:00:00

abstract：:1. To analyze further the sensory mechanisms for triggering the lordosis reflex, single-unit (n = 345) activity was recorded extracellularly from spinal segments L5-S1 of urethan-anesthetized female rats. Unit responses to pressure on the skin (necessary and sufficient for evoking lordosis) and other mechanical stimul...

journal_title：Journal of neurophysiology

authors： Kow LM,Zemlan FP,Pfaff DW

更新日期：1980-01-01 00:00:00

abstract：:The deep dorsal horn represents a major site for the integration of spinal sensory information. The bulbospinal monoamine transmitters, released from serotonergic, noradrenergic, and dopaminergic systems, exert modulatory control over spinal sensory systems as does acetylcholine, an intrinsic spinal cord biogenic amin...

journal_title：Journal of neurophysiology

authors： Garraway SM,Hochman S

更新日期：2001-11-01 00:00:00

abstract：:The mouse is an important model system for investigating the neural circuits mediating behavior. Because of advances in imaging and optogenetic methods, head-fixed mouse preparations provide an unparalleled opportunity to observe and control neural circuits. To investigate how neural circuits produce behavior, these m...

journal_title：Journal of neurophysiology

authors： Sanders JI,Kepecs A

更新日期：2012-12-01 00:00:00

abstract：:Previous reports have indicated that the premotor cortex (PM) uses visual information for either direct guidance of limb movements or indirect specification of action targets at a conceptual level. We explored how visual inputs signaling these two different categories of information are processed by PM neurons. Monkey...

journal_title：Journal of neurophysiology

authors： Yamagata T,Nakayama Y,Tanji J,Hoshi E

更新日期：2009-12-01 00:00:00

abstract：:The underlying neurophysiology of postural control of the lower back in humans is poorly understood. We have characterized motor unit (MU) discharge activity in the deep lumbar multifidus (LM) muscle in nine healthy subjects (20-40 yr, 3 females). Bilateral fine wire electrodes were implanted at L4 spinal level using ...

journal_title：Journal of neurophysiology

authors： Lothe LR,Raven TJ,Eken T

更新日期：2015-08-01 00:00:00

abstract：:The aim of this study was to investigate how maximal intermittent contractions for a hand muscle influence cortical and reflex activity, as well as the ability to voluntarily activate, the homologous muscle in the opposite limb. Twelve healthy subjects (age: 24 ± 3 years, all right hand dominant) performed maximal con...

journal_title：Journal of neurophysiology

authors： Kavanagh JJ,Feldman MR,Simmonds MJ

更新日期：2016-11-01 00:00:00

abstract：:1. Simultaneous, whole-cell recordings were obtained from synaptically coupled photoreceptor/bipolar cell pairs, by the use of direct visualization in a superfused, mudpuppy retinal slice preparation. 2. OFF-bipolar cells (BPs) generated sign-conserving responses when extrinsic current was injected into rods and cones...

journal_title：Journal of neurophysiology

authors： Kim HG,Miller RF

更新日期：1993-02-01 00:00:00

abstract：:Glass micropipettes were used to record the activity of 124 single units in the somatosensory vibrissa cortex (SI) of 16 rats in response to combined deflections of contralateral vibrissae. Compact multiangular electromechanical stimulators were used to stimulate individual vibrissal hairs alone or in combinations of ...

journal_title：Journal of neurophysiology

authors： Simons DJ

更新日期：1985-09-01 00:00:00

abstract：:Ca2+ currents in dorsal unpaired median (DUM) neurons isolated from the fifth abdominal ganglion of the cockroach Periplaneta americana were investigated with the whole cell patch-clamp technique. On the basis of kinetic and pharmacological properties, two different Ca2+ currents were separated in these cells: mid/low...

journal_title：Journal of neurophysiology

authors： Wicher D,Penzlin H

更新日期：1997-01-01 00:00:00

abstract：:Spontaneous calcium oscillations in mushroom bodies of late stage pupal and adult Drosophila brains have been implicated in memory consolidation during olfactory associative learning. This study explores the cellular mechanisms regulating calcium dynamics in Kenyon cells, principal neurons in mushroom bodies. Fura-2 i...

journal_title：Journal of neurophysiology

authors： Jiang SA,Campusano JM,Su H,O'Dowd DK

更新日期：2005-07-01 00:00:00

abstract：:1. Spatiotemporal receptive fields (RFs) for left and right eyes were studied for simple cells in the cat's striate cortex to examine the idea that stereoscopic depth information is encoded via structural differences of RFs between the two eyes. Traditional models are based on neurons that possess matched RF profiles ...

journal_title：Journal of neurophysiology

authors： Ohzawa I,DeAngelis GC,Freeman RD

更新日期：1996-05-01 00:00:00

abstract：:1. Somatic K currents of cultured hippocampal, striatal, and spinal cord neurons of embryonic rat were recorded under voltage clamp in membrane spheres ("blebs") excised by means of a tight-seal pipette. 2. The somatic K current in blebs was subject to rapid and near complete inactivation during 300-ms depolarizations...

journal_title：Journal of neurophysiology

authors： Rizzo MA,Nonner W

更新日期：1992-11-01 00:00:00

abstract：:1. In a previous study, using a chronic cat preparation subjected to an associative conditioning procedure, we described the plasticity of the thalamo-cortical pathway by qualitatively and quantitatively analyzing the motor responses induced by stimulating each of the relays on the cerebello-thalamo-cortical pathway. ...

journal_title：Journal of neurophysiology

authors： Meftah EM,Rispal-Padel L

更新日期：1994-12-01 00:00:00

abstract：:1. Preliminary to extending a point process model of lateral superior olive (LSO) unit activity to describe the units' binaural responses, the statistical properties of their discharges to binaural tone bursts were studied. The hypothesis that stimulation of the contralateral ear results in the simple reduction of the...

journal_title：Journal of neurophysiology

authors： Tsuchitani C

更新日期：1988-01-01 00:00:00

abstract：:Neurons integrate subthreshold inputs in a frequency-dependent manner. For sinusoidal stimuli, response amplitudes thus vary with stimulus frequency. Neurons in entorhinal cortex show two types of such resonance behavior: stellate cells in layer II exhibit a prominent peak in the resonance profile at stimulus frequenc...

journal_title：Journal of neurophysiology

authors： Schreiber S,Erchova I,Heinemann U,Herz AV

更新日期：2004-07-01 00:00:00

abstract：:1. Plasticity at the connections between sensory neurons and their follower cells in Aplysia has been used extensively as a model system to examine mechanisms of simple forms of learning. Earlier studies have concluded that serotonin (5-HT) is a key modulatory transmitter and that it exerts its short-term actions via ...

journal_title：Journal of neurophysiology

authors： Sugita S,Goldsmith JR,Baxter DA,Byrne JH

更新日期：1992-08-01 00:00:00

abstract：:Electrical stimulation of the median nerve at the wrist may elicit a blink reflex [hand blink reflex (HBR)] mediated by a neural circuit at brain stem level. As, in a Sherringtonian sense, the blink reflex is a defensive response, in a series of experiments we tested, in healthy volunteers, whether and how the HBR is ...

journal_title：Journal of neurophysiology

authors： Sambo CF,Liang M,Cruccu G,Iannetti GD

更新日期：2012-02-01 00:00:00

abstract：:Circulating glucose levels significantly affect vagal neural activity, which is important in the regulation of pancreatic functions. Little is known about the mechanisms involved. This study investigates the neural pathways responsible for hypoglycemia-induced vagal efferent signaling to the pancreas and identifies th...

journal_title：Journal of neurophysiology

authors： Wu X,Gao J,Yan J,Owyang C,Li Y

更新日期：2004-04-01 00:00:00

abstract：:Coupled oscillatory activity recorded between sensorimotor regions of the basal ganglia-thalamocortical loop is thought to reflect information transfer relevant to movement. A neuronal firing-rate model of basal ganglia-thalamocortical circuitry, however, has dominated thinking about basal ganglia function for the pas...

journal_title：Journal of neurophysiology

authors： Lipski WJ,Wozny TA,Alhourani A,Kondylis ED,Turner RS,Crammond DJ,Richardson RM

更新日期：2017-09-01 00:00:00

abstract：:Processing of temporal information is key in auditory processing. In this study, we recorded single-unit activity from rat auditory cortex while they performed an interval-discrimination task. The animals had to decide whether two auditory stimuli were separated by either 150 or 300 ms and nose-poke to the left or to ...

journal_title：Journal of neurophysiology

authors： Abolafia JM,Martinez-Garcia M,Deco G,Sanchez-Vives MV

更新日期：2013-11-01 00:00:00

abstract：:Neurons in the medial superior olive (MSO) are tuned to the interaural time difference (ITD) of sound arriving at the two ears. MSO neurons evoke a strongest response at their best delay (BD), at which the internal delay between bilateral inputs to MSO matches the external ITD. We performed extracellular recordings in...

journal_title：Journal of neurophysiology

authors： Day ML,Semple MN

更新日期：2011-10-01 00:00:00

abstract：:Visual and motor properties of single neurons of monkey ventral premotor cortex (area F5) were studied in a behavioral paradigm consisting of four conditions: object grasping in light, object grasping in dark, object fixation, and fixation of a spot of light. The employed objects were six different three-dimensional (...

journal_title：Journal of neurophysiology

authors： Murata A,Fadiga L,Fogassi L,Gallese V,Raos V,Rizzolatti G

更新日期：1997-10-01 00:00:00

abstract：:Inactivation permits direct assessment of the functional contribution of a given brain area to behavior. Previous inactivation studies of the frontal eye field (FEF) have either used large permanent ablations or reversible pharmacological techniques that only inactivate a small volume of tissue. Here we evaluated the ...

journal_title：Journal of neurophysiology

authors： Peel TR,Johnston K,Lomber SG,Corneil BD

更新日期：2014-01-01 00:00:00

abstract：:We have demonstrated that 4-aminopyridine-3-methanol (4-AP-3-MeOH), a 4-aminopyridine derivative, significantly restores axonal conduction in stretched spinal cord white-matter strips and shows no preference in restoring large and small axons. This compound is 10 times more potent when compared with 4-AP and other der...

journal_title：Journal of neurophysiology

authors： Sun W,Smith D,Fu Y,Cheng JX,Bryn S,Borgens R,Shi R

更新日期：2010-01-01 00:00:00

abstract：:1. The electrical threshold of the terminations of single group Ia and II afferent fibers was transiently reduced by the antidromic discharge of the initial segment of spinal motoneurons in the cat. 2. This depolarization of the terminals of afferent fibers known to synapse on motoneurons confirms previous observation...

journal_title：Journal of neurophysiology

authors： Curtis DR,Lodge D,Headley PM

更新日期：1979-05-01 00:00:00

abstract：:The role of dorsal root reflexes (DRRs) in acute cutaneous neurogenic inflammation induced by intradermal injection of capsaicin (CAP) was examined in anesthetized rats. Changes in cutaneous blood flow (flare) on the plantar surface of the foot were measured using a laser Doppler flowmeter, and neurogenic edema was ex...

journal_title：Journal of neurophysiology

authors： Lin Q,Wu J,Willis WD

更新日期：1999-11-01 00:00:00

abstract：:Experience-dependent modification in the electrical properties of central neurons is a form of intrinsic plasticity that occurs during development and has been observed following behavioral learning. We report a novel form of intrinsic plasticity in hippocampal CA1 pyramidal neurons mediated by the KV7/KCNQ and CaV1/L...

journal_title：Journal of neurophysiology

authors： Wu WW,Chan CS,Surmeier DJ,Disterhoft JF

更新日期：2008-10-01 00:00:00