Involvement of protein kinase C in serotonin-induced spike broadening and synaptic facilitation in sensorimotor connections of Aplysia.


:1. Plasticity at the connections between sensory neurons and their follower cells in Aplysia has been used extensively as a model system to examine mechanisms of simple forms of learning. Earlier studies have concluded that serotonin (5-HT) is a key modulatory transmitter and that it exerts its short-term actions via cAMP-dependent activation of protein kinase A. Subsequently, it has become clear that other kinase systems such as protein kinase C (PKC) also may be involved in the actions of 5-HT. 2. Application of phorbol esters, which activate PKC, produced a slowly developing spike broadening but had little effect on excitability (a process known to be primarily cAMP dependent). Moreover, the effects of phorbol esters and 5-HT on spike duration were not additive, suggesting that they may share some common mechanisms. 3. The protein kinase inhibitor staurosporine suppressed both 5-HT-induced slowly developing spike broadening and, under certain conditions, facilitation of transmitter release. Staurosporine did not inhibit 5-HT-induced enhancement of excitability. The effectiveness of staurosporine on spike broadening was dependent on the time at which spike broadening was examined after application of 5-HT. Staurosporine appeared to have little effect on spike broadening 3 min after application of 5-HT, whereas it inhibited significantly 5-HT-induced spike broadening at later times. The staurosporine-insensitive component of 5-HT-induced spike broadening may be mediated by cAMP. 4. The results suggest that the activation of PKC plays a key role in components of both 5-HT-induced spike broadening and facilitation of synaptic transmission.(ABSTRACT TRUNCATED AT 250 WORDS)


J Neurophysiol


Sugita S,Goldsmith JR,Baxter DA,Byrne JH




Has Abstract


1992-08-01 00:00:00












  • Joint and separate effects of estrogen and progesterone on responses of midbrain neurons to lordosis-controlling somatic stimuli in the female golden Syrian hamster.

    abstract::Single midbrain neurons were examined for effects of ovarian hormone administration on responsiveness to an array of lordosis-controlling types of somatosensory stimuli in anesthetized, ovariectomized Syrian hamsters. Neuronal responses were recorded under four different hormonal treatment conditions: 1) estradiol ben...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Rose JD,Bieber SL

    更新日期:1984-05-01 00:00:00

  • Errors in pointing are due to approximations in sensorimotor transformations.

    abstract::1. We define an extrinsic frame of reference to represent the location of a point in extrapersonal space relative to a human subject's shoulder, and we define an intrinsic frame of reference to represent the orientation of the arm and forearm. 2. We examined the relations between coordinates in the extrinsic and intri...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Soechting JF,Flanders M

    更新日期:1989-08-01 00:00:00

  • Discharge of spindle afferents from jaw-closing muscles during chewing in alert monkeys.

    abstract::The discharge of muscle spindle afferents from monkey spindle afferents from monkey jaw-closing muscles was studied during mastication of natural foods by extracellular recording from the fibers or cell bodies of the tract and mesencephalic nucleus of the fifth nerve. In all, 39 muscle afferents were studied. The spin...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Goodwin GM,Luschei ES

    更新日期:1975-05-01 00:00:00

  • Selectivity for space and time in early areas of the auditory dorsal stream in the rhesus monkey.

    abstract::The respective roles of ventral and dorsal cortical processing streams are still under discussion in both vision and audition. We characterized neural responses in the caudal auditory belt cortex, an early dorsal stream region of the macaque. We found fast neural responses with elevated temporal precision as well as n...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Kusmierek P,Rauschecker JP

    更新日期:2014-04-01 00:00:00

  • Effects of bis(7)-tacrine on spontaneous synaptic activity and on the nicotinic ACh receptor of Torpedo electric organ.

    abstract::Bis(7)-tacrine is a potent acetylcholinesterase inhibitor in which two tacrine molecules are linked by a heptylene chain. We tested the effects of bis(7)-tacrine on the spontaneous synaptic activity. Miniature endplate potentials (MEPPs) were recorded extracellularly on slices of electric organ of Torpedo marmorata. B...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Ros E,Aleu J,Gomez de Aranda I,Cantí C,Pang YP,Marsal J,Solsona C

    更新日期:2001-07-01 00:00:00

  • Concentration-jump experiments with NMDA antagonists in mouse cultured hippocampal neurons.

    abstract::1. Voltage-clamp experiments were used to study N-methyl-D-aspartic acid (NMDA) receptor antagonists applied by fast perfusion to mouse hippocampal neurons in dissociated culture. 2. Preincubation with the NMDA antagonists zinc (3-30 microM) and magnesium (30-300 microM) reduced subsequent responses to 100 microM NMDA...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Benveniste M,Mienville JM,Sernagor E,Mayer ML

    更新日期:1990-06-01 00:00:00

  • Neuronal activity in macaque supplementary eye field during planning of saccades in response to pattern and spatial cues.

    abstract::The aim of this study was to determine whether neuronal activity in the macaque supplementary eye field (SEF) is influenced by the rule used for saccadic target selection. Two monkeys were trained to perform a variant of the memory-guided saccade task in which any of four visible dots (rightward, upward, leftward, and...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Olson CR,Gettner SN,Ventura V,Carta R,Kass RE

    更新日期:2000-09-01 00:00:00

  • Generalizing movement patterns following shoulder fixation.

    abstract::Generalizing newly learned movement patterns beyond the training context is challenging for most motor learning situations. Here we tested whether learning of a new physical property of the arm during self-initiated reaching generalizes to new arm configurations. Human participants performed a single-joint elbow reach...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Maeda RS,Zdybal JM,Gribble PL,Pruszynski JA

    更新日期:2020-03-01 00:00:00

  • Electrophysiological correlates of incidentally learned expectations in human vision.

    abstract::The human visual system is remarkably sensitive to environmental regularities, which can facilitate behavioral performance when sensory events conform to past experience. The point at which prior knowledge is integrated during visual perception is unclear, particularly for incidentally learned associations. One possib...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Hall MG,Mattingley JB,Dux PE

    更新日期:2018-04-01 00:00:00

  • Aftereffects in the responses of cat muscle spindles.

    abstract::Responses have been recorded from primary endings of muscle spindles in the cat soleus muscle. Changes in spindle responsiveness were measured following a period of conditioning that consisted of a series of rapid stretches or of tetanic ventral root stimulation. In the testing procedure the response of a single spind...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Gregory JE,Morgan DL,Proske U

    更新日期:1986-08-01 00:00:00

  • Encoding of movement dynamics by Purkinje cell simple spike activity during fast arm movements under resistive and assistive force fields.

    abstract::It is controversial whether simple-spike activity of cerebellar Purkinje cells during arm movements encodes movement kinematics like velocity or dynamics like muscle activities. To examine this issue, we trained monkeys to flex or extend the elbow by 45 degrees in 400 ms under resistive and assistive force fields but ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Yamamoto K,Kawato M,Kotosaka S,Kitazawa S

    更新日期:2007-02-01 00:00:00

  • Mechanoafferent neuron with an inexcitable somatic region: consequences for the regulation of spike propagation and afferent transmission.

    abstract::In the Aplysia mechanoafferent B21, afferent transmission is in part regulated via the control of active spike propagation. When B21 is peripherally activated at its resting membrane potential, spikes fail to propagate to an output process, and afferent transmission does not occur. In this report, we show that the pro...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Evans CG,Ludwar BCh,Cropper EC

    更新日期:2007-04-01 00:00:00

  • A learning and memory area in the octopus brain manifests a vertebrate-like long-term potentiation.

    abstract::Cellular mechanisms underlying learning and memory were investigated in the octopus using a brain slice preparation of the vertical lobe, an area of the octopus brain involved in learning and memory. Field potential recordings revealed long-term potentiation (LTP) of glutamatergic synaptic field potentials similar to ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Hochner B,Brown ER,Langella M,Shomrat T,Fiorito G

    更新日期:2003-11-01 00:00:00

  • Early coding of reaching in the parietooccipital cortex.

    abstract::Neural activity was recorded in the parietooccipital cortex while monkeys performed different tasks aimed at investigating visuomotor interactions of retinal, eye, and arm-related signals on neural activity. The tasks were arm reaching 1) to foveated targets; 2) to extrafoveal targets, with constant eye position; 3) w...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Battaglia-Mayer A,Ferraina S,Mitsuda T,Marconi B,Genovesio A,Onorati P,Lacquaniti F,Caminiti R

    更新日期:2000-04-01 00:00:00

  • Specificity of color connectivity between primate V1 and V2.

    abstract::To examine the functional interactions between the color and form pathways in the primate visual cortex, we have examined the functional connectivity between pairs of color oriented and nonoriented V1 and V2 neurons in Macaque monkeys. Optical imaging maps for color selectivity, orientation preference, and ocular domi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Roe AW,Ts'o DY

    更新日期:1999-11-01 00:00:00

  • Long-term expression of two interacting motor pattern-generating networks in the stomatogastric system of freely behaving lobster.

    abstract::Rhythmic movements of the gastric mill and pyloric regions of the crustacean foregut are controlled by two stomatogastric neuronal networks that have been intensively studied in vitro. By using electromyographic recordings from the European lobster, Homarus gammarus, we have monitored simultaneously the motor activity...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Clemens S,Combes D,Meyrand P,Simmers J

    更新日期:1998-03-01 00:00:00

  • Glutamate and GABA activate different receptors and Cl(-) conductances in crab peptide-secretory neurons.

    abstract::Responses to rapid application of glutamic acid (Glu) and gamma-aminobutyric acid (GABA), 0.01-3 mM, were recorded by whole-cell patch clamp of cultured crab (Cardisoma carnifex) X-organ neurons. Responses peaked within 200 ms. Both Glu and GABA currents had reversal potentials that followed the Nernst Cl(-) potential...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Duan S,Cooke IM

    更新日期:2000-01-01 00:00:00

  • Induction of voltage-dependent sodium channels by in vitro differentiation of human retinoblastoma cells.

    abstract::1. Neuronlike differentiation of Y-79 retinoblastoma was chemically induced in vitro, by plating the cells onto a poly-D-lysine and laminin substrate. The changes in voltage-dependent conductances after 48-72 h were examined with the whole-cell tight-seal and the perforated-patch recording techniques. 2. Although outw...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: del Pilar Gomez M,Waloga G,Nasi E

    更新日期:1993-10-01 00:00:00

  • Somatosensory perceptual training enhances motor learning by observing.

    abstract::Action observation activates brain regions involved in sensory-motor control. Recent research has shown that action observation can also facilitate motor learning; observing a tutor undergoing motor learning results in functional plasticity within the motor system and gains in subsequent motor performance. However, th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: McGregor HR,Cashaback JGA,Gribble PL

    更新日期:2018-12-01 00:00:00

  • Encoding of compressive stress during indentation by slowly adapting type I mechanoreceptors in rat hairy skin.

    abstract::The mechanical state encoded by slowly adapting type 1 mechanoreceptors (SAI) during indentation was examined using an isolated preparation in a rat model. Skin and its intact innervation were harvested from the medial thigh of the rat hindlimb and placed in a dish, with the corium side down, containing synthetic inte...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Ge W,Khalsa PS

    更新日期:2002-04-01 00:00:00

  • Encoder adaptation modulates the visual responses of crayfish interneurons.

    abstract::The responses of sustaining and dimming fibers were characterized by the time varying firing rates elicited by extrinsic current and flashes of light. These data were simulated by an adaptive integrate-and-fire model. A postimpulse shunt conductance simulated spike-frequency adaptation. The correlation between observe...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Glantz RM,Schroeter JP

    更新日期:2004-07-01 00:00:00

  • In vivo responses of single olfactory receptor neurons of channel catfish to binary mixtures of amino acids.

    abstract::For the first time in any vertebrate, in vivo responses of single olfactory receptor neurons to odorant mixtures were studied quantitatively. Extracellular electrophysiological response of 54 single olfactory receptor neurons from 23 channel catfish, Ictalurus punctatus, to binary mixtures of amino acids and to their ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Kang J,Caprio J

    更新日期:1997-01-01 00:00:00

  • Mechanisms underlying rule learning-induced enhancement of excitatory and inhibitory synaptic transmission.

    abstract::Training rats to perform rapidly and efficiently in an olfactory discrimination task results in robust enhancement of excitatory and inhibitory synaptic connectivity in the rat piriform cortex, which is maintained for days after training. To explore the mechanisms by which such synaptic enhancement occurs, we recorded...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Saar D,Reuveni I,Barkai E

    更新日期:2012-02-01 00:00:00

  • Large-scale imaging of cortical dynamics during sensory perception and behavior.

    abstract::Sensory-driven behaviors engage a cascade of cortical regions to process sensory input and generate motor output. To investigate the temporal dynamics of neural activity at this global scale, we have improved and integrated tools to perform functional imaging across large areas of cortex using a transgenic mouse expre...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Wekselblatt JB,Flister ED,Piscopo DM,Niell CM

    更新日期:2016-06-01 00:00:00

  • Reorganization of movement representations in primary motor cortex following focal ischemic infarcts in adult squirrel monkeys.

    abstract::1. Intracortical microstimulation (ICMS) techniques were used to derive detailed maps of distal forelimb movement representations in primary motor cortex (area 4) of adult squirrel monkeys before and a few months after a focal ischemic infarct. 2. Infarcts caused a marked but transient deficit in use of the contralate...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Nudo RJ,Milliken GW

    更新日期:1996-05-01 00:00:00

  • Generalization of dynamics learning across changes in movement amplitude.

    abstract::Studies on generalization show the nature of how learning is encoded in the brain. Previous studies have shown rather limited generalization of dynamics learning across changes in movement direction, a finding that is consistent with the idea that learning is primarily local. In contrast, studies show a broader patter...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Mattar AA,Ostry DJ

    更新日期:2010-07-01 00:00:00

  • Behavioral triggers of skin conductance responses and their neural correlates in the primate amygdala.

    abstract::The amygdala plays a crucial role in evaluating the emotional significance of stimuli and in transforming the results of this evaluation into appropriate autonomic responses. Lesion and stimulation studies suggest involvement of the amygdala in the generation of the skin conductance response (SCR), which is an indirec...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Laine CM,Spitler KM,Mosher CP,Gothard KM

    更新日期:2009-04-01 00:00:00

  • Neural network based on the input organization of an identified neuron signaling impending collision.

    abstract::1. We describe a four-layered neural network (Fig. 1), based on the input organization of a collision signaling neuron in the visual system of the locust, the lobula giant movement detector (LGMD). The 250 photoreceptors ("P" units) in layer 1 are excited by any change in illumination, generated when an image edge pas...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Rind FC,Bramwell DI

    更新日期:1996-03-01 00:00:00

  • Existence in the nucleus incertus of the cat of horizontal-eye-movement-related neurons projecting to the cerebellar flocculus.

    abstract::1. Properties of nucleus incertus (NIC) neurons projecting to the cerebellar flocculus were studied in alert cats by using chronic unit and eye movement recording and antidromic activation. Projection of these neurons onto the flocculus was verified with retrograde transport of horseradish peroxidase after injections ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Cheron G,Saussez S,Gerrits N,Godaux E

    更新日期:1995-09-01 00:00:00

  • Shrinkage of somatosensory hand area in subjects with upper extremity dysmelia revealed by magnetoencephalography.

    abstract::The effect of peripheral lesions on cerebral somatosensory representations is well studied for experimentally induced amputations and deafferentations acquired later in life. However, few studies have investigated the brain's capacity for plastic changes in congenital malformations. We studied somatosensory-evoked fie...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Stoeckel MC,Pollok B,Witte OW,Seitz RJ,Schnitzler A

    更新日期:2005-02-01 00:00:00