Characterization of voltage-gated K+ currents contributing to subthreshold membrane potential oscillations in hippocampal CA1 interneurons.

Abstract:

:CA1 inhibitory interneurons at the stratum lacunosum-moleculare and radiatum junction (LM/RAD-INs) display subthreshold membrane potential oscillations (MPOs) involving voltage-dependent Na(+) and A-type K(+) currents. LM/RAD-INs also express other voltage-gated K(+) currents, although their properties and role in MPOs remain unclear. Here, we characterized these voltage-gated K(+) currents and investigated their role in MPOs. Using outside-out patch recordings from LM/RAD-IN somata, we distinguished four voltage-gated K(+) currents based on their pharmacology and activation/inactivation properties: a fast delayed rectifier current (I(Kfast)), a slow delayed rectifier current (I(Kslow)), a rapidly inactivating A-type current (I(A)), and a slowly inactivating current (I(D)). Their relative contribution to the total K(+) current was I(A) > I(Kfast) > I(Kslow) = I(D). The presence of I(D) and the relative contributions of K(+) currents in LM/RAD-INs are different from those of other CA1 interneurons, suggesting the presence of differential complement of K(+) currents in subgroups of interneurons. We next determined whether these K(+) currents were sufficient for MPO generation using a single-compartment model of LM/RAD-INs. The model captured the subthreshold voltage dependence of MPOs. Moreover, all K(+) currents were active at subthreshold potentials but I(D), I(A), and the persistent sodium current (I(NaP)) were most active near threshold. Using impedance analysis, we found that I(A) and I(NaP) contribute to MPO generation by modulating peak spectral frequency during MPOs and governing the voltage range over which MPOs occur. Our findings uncover a differential expression of a complement of K(+) channels that underlies intrinsic rhythmic activity in inhibitory interneurons.

journal_name

J Neurophysiol

authors

Morin F,Haufler D,Skinner FK,Lacaille JC

doi

10.1152/jn.00848.2009

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

3472-89

issue

6

eissn

0022-3077

issn

1522-1598

pii

jn.00848.2009

journal_volume

103

pub_type

杂志文章
  • Differential impairment of individuated finger movements in humans after damage to the motor cortex or the corticospinal tract.

    abstract::The purpose of this study was to quantify the long-term loss of independent finger movements in humans with lesions relatively restricted to motor cortex or corticospinal tract. We questioned whether damage to the motor cortex or corticospinal tract would permanently affect the ability to move each finger to the same ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00130.2003

    authors: Lang CE,Schieber MH

    更新日期:2003-08-01 00:00:00

  • Multimodal sensory responses of nucleus reticularis gigantocellularis and the responses' relation to cortical and motor activation.

    abstract::The connectivity of large neurons of the nucleus reticularis gigantocellularis (NRGc) in the medullary reticular formation potentially allows both for the integration of stimuli, in several modalities, that would demand immediate action, and for coordinated activation of cortical and motoric activity. We have simultan...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01122.2009

    authors: Martin EM,Pavlides C,Pfaff D

    更新日期:2010-05-01 00:00:00

  • Cortical hemoglobin concentration changes underneath the coil after single-pulse transcranial magnetic stimulation: a near-infrared spectroscopy study.

    abstract::Using near-infrared spectroscopy (NIRS) and multichannel probes, we studied hemoglobin (Hb) concentration changes when single-pulse transcranial magnetic stimulation (TMS) was applied over the left hemisphere primary motor cortex (M1). Seventeen measurement probes were centered over left M1. Subjects were studied in b...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00980.2011

    authors: Furubayashi T,Mochizuki H,Terao Y,Arai N,Hanajima R,Hamada M,Matsumoto H,Nakatani-Enomoto S,Okabe S,Yugeta A,Inomata-Terada S,Ugawa Y

    更新日期:2013-03-01 00:00:00

  • Spatial sensitivity in the dorsal zone (area DZ) of cat auditory cortex.

    abstract::We compared the spatial sensitivity of neural responses in three areas of cat auditory cortex: primary auditory cortex (A1), the posterior auditory field (PAF), and the dorsal zone (DZ). Stimuli were 80-ms pure tones or broadband noise bursts varying in free-field azimuth (in the horizontal plane) or elevation (in the...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00104.2005

    authors: Stecker GC,Harrington IA,Macpherson EA,Middlebrooks JC

    更新日期:2005-08-01 00:00:00

  • Exercise-mediated alteration of hippocampal Dicer mRNA and miRNAs is associated with lower BACE1 gene expression and Aβ1-42 in female 3xTg-AD mice.

    abstract::Changes to cerebral miRNA expression have been implicated in the progression of Alzheimer's disease (AD), as miRNAs that regulate the expression of gene products involved in amyloid beta (Aβ) processing, such as BACE1, are dysregulated in those that suffer from AD. Exercise training improves cognition and reduces BACE...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00503.2020

    authors: Dungan CM,Valentino T,Vechetti IJ Jr,Zdunek CJ,Murphy MP,Lin AL,McCarthy JJ,Peterson CA

    更新日期:2020-12-01 00:00:00

  • Effect of temperature on electrical resonance in leopard frog saccular hair cells.

    abstract::Leopard frog saccular hair cells exhibit an electrical resonance in response to a depolarizing stimulus that has been proposed to contribute to the tuning properties of the frog sacculus by acting as an electrical band-pass filter. With the whole cell patch-clamp technique, we have investigated the effect of temperatu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.1.312

    authors: Smotherman MS,Narins PM

    更新日期:1998-01-01 00:00:00

  • Long-term neuromodulatory regulation of a motor pattern-generating network: maintenance of synaptic efficacy and oscillatory properties.

    abstract::Rhythm generation by the pyloric motor network in the stomatogastric ganglion (STG) of the spiny lobster requires permissive neuromodulatory inputs from other central ganglia. When these inputs to the STG are suppressed by cutting the single, mainly afferent stomatogastric nerve (stn), pyloric neurons cease to burst a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00482.2001

    authors: Thoby-Brisson M,Simmers J

    更新日期:2002-12-01 00:00:00

  • Postural adjustments for online corrections of arm movements in standing humans.

    abstract::The aim of this study was to investigate how humans correct ongoing arm movements while standing. Specifically, we sought to understand whether the postural adjustments in the legs required for online corrections of arm movements are predictive or rely on feedback from the moving limb. To answer this question we measu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00944.2010

    authors: Leonard JA,Gritsenko V,Ouckama R,Stapley PJ

    更新日期:2011-05-01 00:00:00

  • Potassium currents in precursor cells isolated from the anterior subventricular zone of the neonatal rat forebrain.

    abstract::The progenitor cells from the anterior part of the neonatal subventricular zone, the SVZa, are unusual in that, although they undergo division, they have a neuronal phenotype. To characterize the electrophysiological properties of the SVZa precursor cells, recordings were made of potassium and sodium currents from SVZ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.1.95

    authors: Stewart RR,Zigova T,Luskin MB

    更新日期:1999-01-01 00:00:00

  • Central input to primary afferent neurons in crayfish, Pacifastacus leniusculus, is correlated with rhythmic motor output of thoracic ganglia.

    abstract::A preparation is described in which the thoracic ganglia of the crayfish are isolated together with the thoracocoxal muscle receptor organ (TCMRO) of the fourth leg. This preparation allows intracellular analysis of both centrally generated and reflex activity in leg motor neurons (MNs). The isolated thoracic ganglia ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1986.55.4.678

    authors: Sillar KT,Skorupski P

    更新日期:1986-04-01 00:00:00

  • The Na+/Ca2+ exchanger inhibitor, KB-R7943, blocks a nonselective cation channel implicated in chemosensory transduction.

    abstract::The mechanism(s) of olfactory transduction in invertebrates remains to be fully understood. In lobster olfactory receptor neurons (ORNs), a nonselective sodium-gated cation (SGC) channel, a presumptive transient receptor potential (TRP)C channel homolog, plays a crucial role in olfactory transduction, at least in part...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90903.2008

    authors: Pezier A,Bobkov YV,Ache BW

    更新日期:2009-03-01 00:00:00

  • Encoding of movement dynamics by Purkinje cell simple spike activity during fast arm movements under resistive and assistive force fields.

    abstract::It is controversial whether simple-spike activity of cerebellar Purkinje cells during arm movements encodes movement kinematics like velocity or dynamics like muscle activities. To examine this issue, we trained monkeys to flex or extend the elbow by 45 degrees in 400 ms under resistive and assistive force fields but ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00206.2006

    authors: Yamamoto K,Kawato M,Kotosaka S,Kitazawa S

    更新日期:2007-02-01 00:00:00

  • Synaptic integration in an excitable dendritic tree.

    abstract::1. Compartmental modeling experiments were carried out in an anatomically characterized neocortical pyramidal cell to study the integrative behavior of a complex dendritic tree containing active membrane mechanisms. Building on a previously presented hypothesis, this work provides further support for a novel principle...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.70.3.1086

    authors: Mel BW

    更新日期:1993-09-01 00:00:00

  • Effects of 5-HT on thalamocortical synaptic transmission in the developing rat.

    abstract::1. Recent immunocytochemical and receptor binding data have demonstrated a transient somatotopic patterning of serotonin (5-HT)-immunoreactive fibers in the primary somatosensory cortex of developing rats and a transient expression of 5-HT1B receptors on thalamocortical axons from the ventral posteromedial thalamic nu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.5.2438

    authors: Rhoades RW,Bennett-Clarke CA,Shi MY,Mooney RD

    更新日期:1994-11-01 00:00:00

  • Differential modulation by copper and zinc of P2X2 and P2X4 receptor function.

    abstract::Differential Modulation by Copper and Zinc of P2X2 and P2X4 Receptor Function. The modulation by Cu2+ and Zn2+ of P2X2 and P2X4 receptors expressed in Xenopus oocytes was studied with the two-electrode, voltage-clamp technique. In oocytes expressing P2X2 receptors, both Cu2+ and Zn2+, in the concentration range 1-130 ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.5.2088

    authors: Xiong K,Peoples RW,Montgomery JP,Chiang Y,Stewart RR,Weight FF,Li C

    更新日期:1999-05-01 00:00:00

  • Temporal evolution of "automatic gain-scaling".

    abstract::The earliest neural response to a mechanical perturbation, the short-latency stretch response (R1: 20-45 ms), is known to exhibit "automatic gain-scaling" whereby its magnitude is proportional to preperturbation muscle activity. Because gain-scaling likely reflects an intrinsic property of the motoneuron pool (via the...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00085.2009

    authors: Pruszynski JA,Kurtzer I,Lillicrap TP,Scott SH

    更新日期:2009-08-01 00:00:00

  • Prehension stability: experiments with expanding and contracting handle.

    abstract::We studied adjustments in digit forces and moments during holding a vertically oriented handle under slow, externally imposed changes in the width of the grasp. Subjects (n = 8) grasped a customized motorized handle with five digits and held it statically in the air. The handle width either increased (expanded) or dec...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00839.2005

    authors: Zatsiorsky VM,Gao F,Latash ML

    更新日期:2006-04-01 00:00:00

  • Active membrane conductances and morphology of a collision detection neuron broaden its impedance profile and improve discrimination of input synchrony.

    abstract::How neurons filter and integrate their complex patterns of synaptic inputs is central to their role in neural information processing. Synaptic filtering and integration are shaped by the frequency-dependent neuronal membrane impedance. Using single and dual dendritic recordings in vivo, pharmacology, and computational...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00048.2019

    authors: Dewell RB,Gabbiani F

    更新日期:2019-08-01 00:00:00

  • Superficial dorsal horn neurons identified by intracutaneous histamine: chemonociceptive responses and modulation by morphine.

    abstract::We have investigated whether neurons in superficial laminae of the spinal dorsal horn respond to intracutaneous (ic) delivery of histamine and other irritant chemicals, and thus might be involved in signaling sensations of itch or chemogenic pain. Single-unit recordings were made from superficial lumbar dorsal horn ne...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.84.2.616

    authors: Jinks SL,Carstens E

    更新日期:2000-08-01 00:00:00

  • Summation of effective synaptic currents and firing rate modulation in cat spinal motoneurons.

    abstract::The aim of this study was to examine how cat spinal motoneurons integrate the synaptic currents generated by the concurrent activation of large groups of presynaptic neurons. We obtained intracellular recordings from cat triceps surae motoneurons and measured the effects of repetitive activity in different sets of pre...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.1.483

    authors: Powers RK,Binder MD

    更新日期:2000-01-01 00:00:00

  • N-methyl-D-aspartate receptors of ganglion cells in rabbit retina.

    abstract::1. Intracellular and extracellular recordings were obtained from ganglion cells in the rabbit retina. The effect of N-methyl-DL-aspartate (NMDLA) and N-methyl-D-aspartate (NMDA) antagonists were studied with the use of a perfusion method for drug application. 2. NMDLA excited all ganglion cell types and caused a chara...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1990.63.1.16

    authors: Massey SC,Miller RF

    更新日期:1990-01-01 00:00:00

  • 9-16 Hz oscillation precedes secondary generalization of seizures in the rat tetanus toxin model of epilepsy.

    abstract::Unilateral intrahippocampal injection of tetanus toxin results in a chronic syndrome of intermittent epileptic seizures. During some of these seizures, rats develop a stereotypic, pathological motor behavior that indicates secondary generalization of epileptic activity. We report that secondary generalization was prec...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.4.2217

    authors: Finnerty GT,Jefferys JG

    更新日期:2000-04-01 00:00:00

  • Excitatory amino acid receptors of the electrosensory system: the NR1/NR2B N-methyl-D-aspartate receptor.

    abstract::The amino acid sequence of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B from the brown ghost knife fish Apteronotus leptorhynchus has been determined and compared with the sequence of the murine NR2B. This comparison revealed high levels of sequence conservation throughout the ligand binding and membrane span...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00629.2002

    authors: Harvey-Girard E,Dunn RJ

    更新日期:2003-02-01 00:00:00

  • Further morphological and electrophysiological studies on snake muscle spindles.

    abstract::1. Electron microscope studies using ruthenium red, horseradish peroxidase, and colloidal lanthanum disclosed a feature characteristic of the snake spindle capsule: it consists of a single layer of flattened cells connected in series, each of which forms a cylinder enclosing the intrafusal fiber. 2. In intact spindles...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1982.47.5.810

    authors: Fukami Y

    更新日期:1982-05-01 00:00:00

  • Morphologically identified cutaneous afferent DRG neurons express three different potassium currents in varying proportions.

    abstract::Outward K+ currents were recorded using a whole cell patch-clamp configuration, from acutely dissociated adult rat cutaneous afferent dorsal root ganglion (DRG) neurons (L4 and L5) identified by retrograde labeling with Fluoro-gold. Recordings were obtained 16-24 h after dissociation from cells between 39 and 49 mm in...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.4.1814

    authors: Everill B,Rizzo MA,Kocsis JD

    更新日期:1998-04-01 00:00:00

  • Shaping the effects of transcranial direct current stimulation of the human motor cortex.

    abstract::Transcranial DC stimulation (tDCS) induces stimulation polarity-dependent neuroplastic excitability shifts in the human brain. Because it accomplishes long-lasting effects and its application is simple, it is used increasingly. However, one drawback is its low focality, caused by 1) the large stimulation electrode and...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01312.2006

    authors: Nitsche MA,Doemkes S,Karaköse T,Antal A,Liebetanz D,Lang N,Tergau F,Paulus W

    更新日期:2007-04-01 00:00:00

  • The spread of attention across features of a surface.

    abstract::Contrasting theories of visual attention have emphasized selection by spatial location, individual features, and whole objects. We used functional magnetic resonance imaging to ask whether and how attention to one feature of an object spreads to other features of the same object. Subjects viewed two spatially superimp...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00828.2012

    authors: Ernst ZR,Boynton GM,Jazayeri M

    更新日期:2013-11-01 00:00:00

  • Submodality distribution in sensorimotor cortex of the unanesthetized monkey.

    abstract::1. Neuronal responses to cutaneous and noncutaneous stimulation were examined in the hindlimb representation of the precentral motor cortex (MI) and the first somatosensory cortex (SI) of unanesthetized monkeys. 2. MI can be divided into two distinct parts of the basis of its afferent input. The rostral part receives ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1981.45.3.467

    authors: Tanji J,Wise SP

    更新日期:1981-03-01 00:00:00

  • Early stages of melody processing: stimulus-sequence and task-dependent neuronal activity in monkey auditory cortical fields A1 and R.

    abstract::To explore the effects of acoustic and behavioral context on neuronal responses in the core of auditory cortex (fields A1 and R), two monkeys were trained on a go/no-go discrimination task in which they learned to respond selectively to a four-note target (S+) melody and withhold response to a variety of other nontarg...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00828.2007

    authors: Yin P,Mishkin M,Sutter M,Fritz JB

    更新日期:2008-12-01 00:00:00

  • Role of proprioceptive signals from an insect femur-tibia joint in patterning motoneuronal activity of an adjacent leg joint.

    abstract::Interjoint reflex function of the insect leg contributes to postural control at rest or to movement control during locomotor movements. In the stick insect (Carausius morosus), we investigated the role that sensory signals from the femoral chordotonal organ (fCO), the transducer of the femur-tibia (FT) joint, play in ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.4.1856

    authors: Hess D,Büschges A

    更新日期:1999-04-01 00:00:00