Push-pull mechanism of selective attention in human extrastriate cortex.

Abstract:

:Selective attention operates in visual cortex by facilitating processing of selected stimuli and by filtering out unwanted information from nearby distracters over circumscribed regions of visual space. The neural representation of unattended stimuli outside this focus of attention is less well understood. We studied the neural fate of unattended stimuli using functional magnetic resonance imaging by dissociating the activity evoked by attended (target) stimuli presented to the periphery of a visual hemifield and unattended (distracter) stimuli presented simultaneously to a corresponding location of the contralateral hemifield. Subjects covertly directed attention to a series of target stimuli and performed either a low or a high attentional-load search task on a stream of otherwise identical stimuli. With this task, target-search-related activity increased with increasing attentional load, whereas distracter-related activity decreased with increasing load in areas V4 and TEO but not in early areas V1 and V2. This finding presents evidence for a load-dependent push-pull mechanism of selective attention that operates over large portions of the visual field at intermediate processing stages. This mechanism appeared to be controlled by a distributed frontoparietal network of brain areas that reflected processes related to target selection during spatially directed attention.

journal_name

J Neurophysiol

authors

Pinsk MA,Doniger GM,Kastner S

doi

10.1152/jn.00974.2003

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

622-9

issue

1

eissn

0022-3077

issn

1522-1598

pii

00974.2003

journal_volume

92

pub_type

杂志文章
  • Glutamate-gated chloride channel with glutamate-transporter-like properties in cone photoreceptors of the tiger salamander.

    abstract::1. Using the patch-clamp technique, we investigated whether the glutamate-elicited current in mechanically isolated cone photoreceptors from the salamander retina is generated by a Cl- channel or a glutamate transporter. 2. The current reversed near the equilibrium potential for Cl-, was decreased by three Cl- channel...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.74.4.1760

    authors: Picaud SA,Larsson HP,Grant GB,Lecar H,Werblin FS

    更新日期:1995-10-01 00:00:00

  • The role of the hippocampus in navigation is memory.

    abstract::There is considerable research on the neurobiological mechanisms within the hippocampal system that support spatial navigation. In this article I review the literature on navigational strategies in humans and animals, observations on hippocampal function in navigation, and studies of hippocampal neural activity in ani...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00005.2017

    authors: Eichenbaum H

    更新日期:2017-04-01 00:00:00

  • Branching points of primary afferent fibers are vital for the modulation of fiber excitability by epidural DC polarization and by GABA in the rat spinal cord.

    abstract::The aim of the study was to examine whether the sustained increases in the excitability of afferent fibers traversing the dorsal columns evoked by their polarization depend on the branching points of these fibers. To this end, the effects of epidural polarization were compared in four spinal regions in deeply anesthet...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00161.2020

    authors: Li Y,Hari K,Lucas-Osma AM,Fenrich KK,Bennett DJ,Hammar I,Jankowska E

    更新日期:2020-07-01 00:00:00

  • Cortical representation of the sensory dimension of pain.

    abstract::It is well accepted that pain is a multidimensional experience, but little is known of how the brain represents these dimensions. We used positron emission tomography (PET) to indirectly measure pain-evoked cerebral activity before and after hypnotic suggestions were given to modulate the perceived intensity of a pain...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.1.402

    authors: Hofbauer RK,Rainville P,Duncan GH,Bushnell MC

    更新日期:2001-07-01 00:00:00

  • Visual cortex neurons of monkeys and cats: temporal dynamics of the contrast response function.

    abstract::Cortical neurons display two fundamental nonlinear response characteristics: contrast-set gain control (also termed contrast normalization) and response expansion (also termed half-squaring). These nonlinearities could play an important role in forming and maintaining stimulus selectivity during natural viewing, but o...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2002.88.2.888

    authors: Albrecht DG,Geisler WS,Frazor RA,Crane AM

    更新日期:2002-08-01 00:00:00

  • Itch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamine-induced itch in humans.

    abstract::Intense itch and urge to scratch are the major symptoms of many chronic skin ailments, which are increasingly common. Vicious itch-scratch cycles are readily established and may diminish quality of life for those afflicted. We investigated peripheral and central processing of two types of itch sensation elicited by sk...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00070.2006

    authors: Leknes SG,Bantick S,Willis CM,Wilkinson JD,Wise RG,Tracey I

    更新日期:2007-01-01 00:00:00

  • Quantitative analysis of static strain sensitivity in human mechanoreceptors from hairy skin.

    abstract::1. Microelectrode recordings from 15 slowly adapting (SA) cutaneous mechanoreceptor afferents originating in hairy skin were obtained from the radial nerve in humans. 2. Controlled skin stretch was applied to the back of the hand that encompassed the physiological range of skin stretch during movements at the metacarp...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1992.67.5.1105

    authors: Edin BB

    更新日期:1992-05-01 00:00:00

  • Functional brain stem circuits for control of nose motion.

    abstract::Rodents shift their nose from side to side when they actively explore and lateralize odors in the space. This motor action is driven by a pair of muscles, the deflector nasi. We studied the premotor control of this motion. We used replication-competent rabies virus to transsynaptically label inputs to the deflector na...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00608.2018

    authors: Kurnikova A,Deschênes M,Kleinfeld D

    更新日期:2019-01-01 00:00:00

  • Whole-cell voltage-clamp study of the fading of GABA-activated currents in acutely dissociated hippocampal neurons.

    abstract::The lability of the responses of mammalian central neurons to gamma-aminobutyric acid (GABA) was studied using neurons acutely dissociated from the CA1 region of the adult guinea pig hippocampus as a model system. GABA was applied to the neuronal somata by pressure ejection and the resulting current (IGABA) recorded u...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1986.56.1.1

    authors: Huguenard JR,Alger BE

    更新日期:1986-07-01 00:00:00

  • Spatial attention enhances the selective integration of activity from area MT.

    abstract::Distinguishing which of the many proposed neural mechanisms of spatial attention actually underlies behavioral improvements in visually guided tasks has been difficult. One attractive hypothesis is that attention allows downstream neural circuits to selectively integrate responses from the most informative sensory neu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00949.2011

    authors: Masse NY,Herrington TM,Cook EP

    更新日期:2012-09-01 00:00:00

  • Human gaze stabilization during natural activities: translation, rotation, magnification, and target distance effects.

    abstract::Stability of images on the retina was determined in 14 normal humans in response to rotational and translational perturbations during self-generated pitch and yaw, standing, walking, and running on a treadmill. The effects on image stability of target distance, vision, and spectacle magnification were examined. During...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.4.2129

    authors: Crane BT,Demer JL

    更新日期:1997-10-01 00:00:00

  • Modification of response functions of cat visual cortical cells by spatially congruent perturbing stimuli.

    abstract::Responses of cat striate cortical cells to a drifting sinusoidal grating were modified by the superimposition of a second, perturbing grating (PG) that did not excite the cell when presented alone. One consequence of the presence of a PG was a shift in the tuning curves. The orientation tuning of all 41 cells exposed ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.6.2703

    authors: Kabara JF,Bonds AB

    更新日期:2001-12-01 00:00:00

  • A molecularly defined cardiorespiratory interneuron expressing SDPFLRFamide/GDPFLRFamide in the snail Lymnaea: monosynaptic connections and pharmacology.

    abstract::1. Neuron-specific expression of alternately spliced exons of the gene encoding the Phe-Met-Arg-Phe-NH2 (FMRFamide) family of neuropeptides and the role of encoded peptides in synaptic transmission were examined in an identified cardiorespiratory interneuron, the visceral white interneuron (VWI), in the snail Lymnaea....

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.69.3.915

    authors: Skingsley DR,Bright K,Santama N,van Minnen J,Brierley MJ,Burke JF,Benjamin PR

    更新日期:1993-03-01 00:00:00

  • Proteinase-activated receptor-1 activation presynaptically enhances spontaneous glutamatergic excitatory transmission in adult rat substantia gelatinosa neurons.

    abstract::Proteinase-activated receptors (PARs) have a unique activation mechanism in that a proteolytically exposed N-terminal region acts as a tethered ligand. A potential impact of PAR on sensory processing has not been fully examined yet. Here we report that synthetic peptides with sequences corresponding to PAR ligands enh...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.91117.2008

    authors: Fujita T,Liu T,Nakatsuka T,Kumamoto E

    更新日期:2009-07-01 00:00:00

  • Comparison of oculomotor neuronal activity in paralaminar and mediodorsal thalamus in the rhesus monkey.

    abstract::We previously reported that neurons in the mediodorsal thalamic nucleus (MD) are topographically organized and express spatial and nonspatial coding properties similar to those of the prefrontal areas with which they are connected. In the course of mapping the dorsal thalamus, we also studied neurons in a subset of th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00969.2003

    authors: Tanibuchi I,Goldman-Rakic PS

    更新日期:2005-01-01 00:00:00

  • Responses of reticulospinal neurons in intact lamprey to vestibular and visual inputs.

    abstract::A lamprey maintains the dorsal-side-up orientation due to the activity of postural control system driven by vestibular input. Visual input can affect the body orientation: illumination of one eye evokes ipsilateral roll tilt. An important element of the postural network is the reticulospinal (RS) neurons transmitting ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.2.864

    authors: Deliagina TG,Fagerstedt P

    更新日期:2000-02-01 00:00:00

  • What does a neuron learn from multisensory experience?

    abstract::The brain's ability to integrate information from different senses is acquired only after extensive sensory experience. However, whether early life experience instantiates a general integrative capacity in multisensory neurons or one limited to the particular cross-modal stimulus combinations to which one has been exp...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00284.2014

    authors: Xu J,Yu L,Stanford TR,Rowland BA,Stein BE

    更新日期:2015-02-01 00:00:00

  • Whiskers, barrels, and cortical efferent pathways in gap crossing by rats.

    abstract::Rats can readily be trained to jump a gap of around 16 cm in the dark and a considerably larger gap in the light for a food reward. In the light, they use vision to estimate the distance to be jumped. In the dark, they use their vibrissae at the farthest distances. Bilateral whisker shaving or barrel field lesions red...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.84.4.1781

    authors: Jenkinson EW,Glickstein M

    更新日期:2000-10-01 00:00:00

  • Ischemic injury suppresses hypoxia-induced electrographic seizures and the background EEG in a rat model of perinatal hypoxic-ischemic encephalopathy.

    abstract::The relationship among neonatal seizures, abnormalities of the electroencephalogram (EEG), brain injury, and long-term neurological outcome (e.g., epilepsy) remains controversial. The effects of hypoxia alone (Ha) and hypoxia-ischemia (HI) were studied in neonatal rats at postnatal day 7; both models generate EEG seiz...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00796.2014

    authors: Zayachkivsky A,Lehmkuhle MJ,Ekstrand JJ,Dudek FE

    更新日期:2015-11-01 00:00:00

  • Contributors to excess antagonist activity during movement in children with secondary dystonia due to cerebral palsy.

    abstract::Children with secondary dystonia due to cerebral palsy exhibit abnormal upper extremity postures and slow voluntary movement. However, the interaction between abnormal postures and abnormal movement in dystonia is still unclear. Some mechanisms by which postures are maintained in dystonia include stretch reflexes, ove...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00998.2009

    authors: Kukke SN,Sanger TD

    更新日期:2011-05-01 00:00:00

  • Mechanisms within the spinal cord are involved in the movement-induced attenuation of an H reflex in the dog.

    abstract::1. H reflexes were elicited in the second interosseous muscle of the hindpaw of the anesthetized dog during passive rotation of the shank about the ipsilateral or contralateral knee. Reflexes sampled at four points in the cycle of movement were compared with stationary controls. For both the ipsilateral and contralate...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.5.3589

    authors: Misiaszek JE,Barclay JK,Brooke JD

    更新日期:1996-11-01 00:00:00

  • Defensive peripersonal space: the blink reflex evoked by hand stimulation is increased when the hand is near the face.

    abstract::Electrical stimulation of the median nerve at the wrist may elicit a blink reflex [hand blink reflex (HBR)] mediated by a neural circuit at brain stem level. As, in a Sherringtonian sense, the blink reflex is a defensive response, in a series of experiments we tested, in healthy volunteers, whether and how the HBR is ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00731.2011

    authors: Sambo CF,Liang M,Cruccu G,Iannetti GD

    更新日期:2012-02-01 00:00:00

  • Neck muscle synergies during stimulation and inactivation of the interstitial nucleus of Cajal (INC).

    abstract::The interstitial nucleus of Cajal (INC) is thought to control torsional and vertical head posture. Unilateral microstimulation of the INC evokes torsional head rotation to positions that are maintained until stimulation offset. Unilateral INC inactivation evokes head position-holding deficits with the head tilted in t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90363.2008

    authors: Farshadmanesh F,Chang P,Wang H,Yan X,Corneil BD,Crawford JD

    更新日期:2008-09-01 00:00:00

  • Response to motion in extrastriate area MSTl: center-surround interactions.

    abstract::The medial superior temporal area of the macaque monkey extrastriate visual cortex can be divided into a dorsal medial (MSTd) and a lateral ventral (MSTl) region. The functions of the two regions may not be identical: MSTd may process optic flow information that results from the movement of the observer, whereas MSTl ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.1.282

    authors: Eifuku S,Wurtz RH

    更新日期:1998-07-01 00:00:00

  • Dopamine regulates distinctively the activity patterns of striatal output neurons in advanced parkinsonian primates.

    abstract::Nigrostriatal dopamine denervation plays a major role in basal ganglia circuitry disarray and motor abnormalities of Parkinson's disease (PD). Studies in rodent and primate models have revealed that striatal projection neurons, namely, medium spiny neurons (MSNs), increase the firing frequency. However, their activity...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00910.2014

    authors: Singh A,Liang L,Kaneoke Y,Cao X,Papa SM

    更新日期:2015-03-01 00:00:00

  • A late phase of LTD in cultured cerebellar Purkinje cells requires persistent dynamin-mediated endocytosis.

    abstract::Long-term synaptic depression (LTD) of cerebellar parallel fiber-Purkinje cell synapses is a form of use-dependent synaptic plasticity that may be studied in cell culture. One form of LTD is induced postsynaptically through an mGlu1/Ca influx/protein kinase Cα (PKCα) cascade, and its initial expression requires phosph...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00824.2011

    authors: Linden DJ

    更新日期:2012-01-01 00:00:00

  • Neurotransmitters producing and modulating opaline gland contraction in Aplysia californica.

    abstract::1. Opaline release in Aplysia provides a simple model system for examining the biochemical and electrophysiological mechanisms underlying glandular secretion and its modulation. The opaline gland is a large multivesicular structure, which is innervated by at least three large identified motor neurons located within th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1982.48.6.1347

    authors: Tritt SH,Byrne JH

    更新日期:1982-12-01 00:00:00

  • The motor inhibitory system operating during active sleep is tonically suppressed by GABAergic mechanisms during other states.

    abstract::The present study was undertaken to explore the neuronal mechanisms responsible for muscle atonia that occurs after the microinjection of bicuculline into the nucleus pontis oralis (NPO). Specifically, we wished to test the hypothesis that motoneurons are postsynaptically inhibited after the microinjection of bicucull...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.4.1908

    authors: Xi MC,Morales FR,Chase MH

    更新日期:2001-10-01 00:00:00

  • Gustatory neural coding in the monkey cortex: mixtures.

    abstract::1. Psychophysicists have shown that the intensity and quality of a taste stimulus, as perceived by humans, is modified by including that stimulus in a mixture. Gustatory neurons in the primary taste cortex (anterior insula and frontal operculum) of the cynomolgus macaque are involved with the coding of stimulus intens...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.75.6.2369

    authors: Plata-Salamán CR,Smith-Swintosky VL,Scott TR

    更新日期:1996-06-01 00:00:00

  • Analysis of afferent responses from isolated semicircular canal of the guitarfish using rotational acceleration white-noise inputs. I. Correlation of response dynamics with receptor innervation.

    abstract::The small-signal linear characteristics of afferent responses from the isolated semicircular canal were described by the use of white-noise rotational acceleration inputs. The results, based on cross-correlation analysis, showed a striking and systematic variation in linear system impulse response characteristics from...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1976.39.3.631

    authors: O'Leary DP,Dunn RF

    更新日期:1976-05-01 00:00:00